Human Heredity and Health (H3) in Africa Kidney Disease Research Network

Osafo, Charlotte; Raji, Yemi Raheem; Burke, David T.; Tayo, Bamidele O.; Tiffin, Nicki; Moxey-Mims, Marva; Rasooly, Rebekah S.; Kimmel, Paul L.; Ojo, Akinlolu; Adu, Dwomoa; Parekh, Rulan S.

doi:10.2215/cjn.11951214

Cited by 45 publications

(32 citation statements)

References 34 publications

(19 reference statements)

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“…It is envisaged that 4000 participants with CKD and 4000 controls will be recruited, as well as 50 families with hereditary glomerular disease. 64…”

Section: Research Synthesismentioning

confidence: 99%

Strengthening Renal Registries and ESRD Research in Africa

Davids

Caskey

Young

et al. 2017

Seminars in Nephrology

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In Africa, the combination of noncommunicable diseases, infectious diseases, exposure to environmental toxins, and acute kidney injury related to trauma and childbirth are driving an epidemic of chronic kidney disease and end-stage renal disease (ESRD). Good registry data can inform the planning of renal services and can be used to argue for better resource allocation, audit the delivery and quality of care, and monitor the impact of interventions. Few African countries have established renal registries and most have failed owing to resource constraints. In this article we briefly review the burden of chronic kidney disease and ESRD in Africa, and then consider the research questions that could be addressed by renal registries. We describe examples of the impact of registry data and summarize the sparse primary literature on country-wide renal replacement therapy in African countries over the past 20 years. Finally, we highlight some initiatives and opportunities for strengthening research on ESRD and renal replacement therapy in Africa. These include the establishment of the African Renal Registry and the availability of new areas for research. We also discuss capacity building, collaboration, open-access publication, and the strengthening of local journals, all measures that may improve the quantity, visibility, and impact of African research outputs.

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“…It is envisaged that 4000 participants with CKD and 4000 controls will be recruited, as well as 50 families with hereditary glomerular disease. 64…”

Section: Research Synthesismentioning

confidence: 99%

Strengthening Renal Registries and ESRD Research in Africa

Davids

Caskey

Young

et al. 2017

Seminars in Nephrology

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“…There are other large NIH-funded consortia that include significant numbers of participants with glomerular disease, although glomerular disease is not their specific focus. These include the Chronic Renal Insufficiency Cohort, the Chronic Kidney Disease in Children Study, and the Human Heredity and Health in Africa Kidney Disease Research Network (16).…”

Section: National Institutes Of Health Investments Requirements Andmentioning

confidence: 99%

Glomerular Diseases: Registries and Clinical Trials

Moxey-Mims¹,

Flessner²,

Holzman³

et al. 2016

CJASN

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Nephrology has conducted few high-quality clinical trials, and the trials that have been conducted have not resulted in the approval of new treatments for primary or inflammatory glomerular diseases. There are overarching process issues that affect the conduct of all clinical trials, but there are also some specialty-specific issues. Within nephrology, primary glomerular diseases are rare, making adequate recruitment for meaningful trials difficult. Nephrologists need better ways, beyond histopathology, to phenotype patients with glomerular diseases and stratify the risk for progression to ESRD. Rigorous trial design is needed for the testing of new therapies, where most patients with glomerular diseases are offered the opportunity to enroll in a clinical trial if standard therapies have failed or are lacking. Training programs to develop a core group of kidney specialists with expertise in the design and implementation of clinical trials are also needed. Registries of patients with glomerular disease and observational studies can aid in the ability to determine realistic estimates of disease prevalence and inform trial design through a better understanding of the natural history of disease. Some proposed changes to the Common Rule, the federal regulations governing the ethical conduct of research involving humans, and the emerging use of electronic health records may facilitate the efficiency of initiating multicenter clinical trials. Collaborations among academia, government scientific and regulatory agencies, industry, foundations, and patient advocacy groups can accelerate therapeutic development for these complex diseases.

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“…Genomic research in Africa is not limited to the bounds of this consortium, but it represents a research infrastructure that enables innovative science. For example, studies covering common diseases such as cardiovascular (Owolabi et al, 2014), neurological (Akinyemi et al, 2016), respiratory (Zar et al, 2016a;Zar et al, 2016b), kidney (Osafo et al, 2015), and other non-communicable diseases are represented in this consortium. Developments in pharmacogenomics (Warnich et al, 2011) and the human microbiome (Adebamowo et al, 2017) are also underway, and many studies incorporate information about HIV, malaria, tuberculosis, and other common infections in Africa.…”

Section: Introductionmentioning

confidence: 99%

Environmental Health Research in Africa: Important Progress and Promising Opportunities

Joubert

Mantooth²,

McAllister

2020

Front. Genet.

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The World Health Organization in 2016 estimated that over 20% of the global disease burden and deaths were attributed to modifiable environmental factors. However, data clearly characterizing the impact of environmental exposures and health endpoints in African populations is limited. To describe recent progress and identify important research gaps, we reviewed literature on environmental health research in African populations over the last decade, as well as research incorporating both genomic and environmental factors. We queried PubMed for peer-reviewed research articles, reviews, or books examining environmental exposures and health outcomes in human populations in Africa. Searches utilized medical subheading (MeSH) terms for environmental exposure categories listed in the March 2018 US National Report on Human Exposure to Environmental Chemicals, which includes chemicals with worldwide distributions. Our search strategy retrieved 540 relevant publications, with studies evaluating health impacts of ambient air pollution (n=105), indoor air pollution (n = 166), heavy metals (n = 130), pesticides (n = 95), dietary mold (n = 61), indoor mold (n = 9), per-and polyfluoroalkyl substances (PFASs, n = 0), electronic waste (n = 9), environmental phenols (n = 4), flame retardants (n = 8), and phthalates (n = 3), where publications could belong to more than one exposure category. Only 23 publications characterized both environmental and genomic risk factors. Cardiovascular and respiratory health endpoints impacted by air pollution were comparable to observations in other countries. Air pollution exposures unique to Africa and some other resource limited settings were dust and specific occupational exposures. Literature describing harmful health effects of metals, pesticides, and dietary mold represented a context unique to Africa. Studies of exposures to phthalates, PFASs, phenols, and flame retardants were very limited. These results underscore the need for further focus on current and emerging environmental and chemical health risks as well as better integration of genomic and environmental factors in African research studies. Environmental exposures with distinct routes of exposure, unique co-exposures and co-morbidities, combined with the extensive genomic diversity in Africa may lead to the identification of novel mechanisms underlying complex disease and promising potential for translation to global public health.

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Human Heredity and Health (H3) in Africa Kidney Disease Research Network

Cited by 45 publications

References 34 publications

Strengthening Renal Registries and ESRD Research in Africa

Strengthening Renal Registries and ESRD Research in Africa

Glomerular Diseases: Registries and Clinical Trials

Environmental Health Research in Africa: Important Progress and Promising Opportunities

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