Human heart transplantation from donation after circulatory-determined death donors using normothermic regional perfusion and cold storage

Messer, Simon; Page, A.; Colah, Simon; Axell, Richard G.; Pařízková, Barbora; Tsui, Steven; Large, Stephen

doi:10.1016/j.healun.2018.03.017

Cited by 86 publications

(69 citation statements)

References 10 publications

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“…[12][13][14] In Australia, the United Kingdom, and more recently in Belgium, upwards of 105 DCD heart transplantations have been performed. [16][17][18][19] The operational aspects of DCD transplantation require teams with well-developed protocols, and in some cases, experience with specialized and costly equipment. NRP, although invasive, requiring reanimation of the heart with the use of extracorporeal membrane oxygenation and cross-clamping of head and neck vessels, is a strategy that allows for reassessment of the heart after a period of warm ischemia.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, ex vivo perfusion systems can also allow for organ optimization and can increase the acceptable distance for organ transportation. [16][17][18][19] The operational aspects of DCD transplantation require teams with well-developed protocols, and in some cases, experience with specialized and costly equipment. Thus, DCD heart procurement and transplantation is limited to only those centers fully equipped to manage the myriad aspects of this procurement strategy.…”

Section: Me Thodsmentioning

confidence: 99%

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Potential for donation after circulatory death heart transplantation in the United States: Retrospective analysis of a limited UNOS dataset

Farr

Truby

Lindower³

et al. 2020

American Journal of Transplantation

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Donation after Circulatory Death (DCD) is an alternative to Donation after Brain death (DBD), and is a growing strategy for organ procurement in the United States(US). The purpose of this analysis was to review the number and quality of hearts in one United Network for Organ Sharing (UNOS) Region that were not utilized as a potential consequence of nonheart DCD donation. We retrospectively identified all successful US DCD solid organ donors from 1/2011 to 3/1/2017, defined an ideal heart donor by age and left ventricular ejection fraction (LVEF), and then reviewed the donor charts of unused hearts in New York and Vermont (UNOS Region 9). Of 8302 successful DCD donors across the United States, 5033 (61%) were between 18 and 49 years of age, and 872 had a screening echocardiogram, with 573 (66%) measuring an EF >50%.Of these 573 potential donors, 44 (7.7%) were from Region 9. Detailed donor chart review identified 36 ideal heart donors, 24 (66.7%) with anoxic brain injury. Trends in Region 9 DCD donation increased from 4 unused hearts in 2011, to 13 in 2016. In the context of severe organ scarcity, these data indicate that implementation of DCD heart transplantation in the United States would improve overall donation rates and provide a pathway to utilize these ideal donor hearts. K E Y W O R D Sclinical research/practice, donors and donation: donation after circulatory death (DCD), donors and donation: donor evaluation, donors and donation: extended criteria, ethics and public policy, heart transplantation/cardiology

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Section: Discussionmentioning

confidence: 99%

Section: Me Thodsmentioning

confidence: 99%

Potential for donation after circulatory death heart transplantation in the United States: Retrospective analysis of a limited UNOS dataset

Farr

Truby

Lindower³

et al. 2020

American Journal of Transplantation

View full text Add to dashboard Cite

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“…They were then placed on OCS (TransMedics) and continued to receive normothermic blood‐based perfusion until transported to recipient hospital 23 Normothermic regional perfusion and cold storage: a single patient report from a veno‐venous ECMO patient who died of smoke inhalation 31 . Cold ischemia time was only 15 minutes.…”

Section: Human Dcd Heart Transplantationmentioning

confidence: 99%

“…Normothermic regional perfusion and cold storage: a single patient report from a veno‐venous ECMO patient who died of smoke inhalation 31 . Cold ischemia time was only 15 minutes.…”

Section: Human Dcd Heart Transplantationmentioning

confidence: 99%

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Heart transplantation from donation after circulatory death donors: Present and future

et al. 2020

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The first successful human heart transplantation was reported on 3 December 1967, by Christiaan Barnard in South Africa. Since then this life‐saving procedure has been performed in over 120 000 patients. A limitation to the performance of this procedure is the availability of donor hearts with as many as 20% of patients dying before a donor's heart is available for transplant. Today, hearts for transplantation are procured from individuals experiencing donation after brain death (DBD). Interestingly, this, however, was not always the case as the first heart transplants occurred after circulatory death. Revisiting the availability of hearts for transplant from those experiencing donation after circulatory death (DCD) could further expand the number of hearts suitable for transplantation. There are several considerations pertinent to transplanting hearts from those undergoing circulatory death. In this review, we summarize the main distinctions between DBD and DCD heart donation and discuss the research relevant to increasing the number of hearts available for transplantation by including individual's hearts that experience circulatory death.

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Cardiac Donor Evaluation

Milano,

Chiang

2023

Textbook of Transplantation and Mechanical Support for End‐Stage Heart and Lung Disease

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Human heart transplantation from donation after circulatory-determined death donors using normothermic regional perfusion and cold storage

Cited by 86 publications

References 10 publications

Potential for donation after circulatory death heart transplantation in the United States: Retrospective analysis of a limited UNOS dataset

Potential for donation after circulatory death heart transplantation in the United States: Retrospective analysis of a limited UNOS dataset

Heart transplantation from donation after circulatory death donors: Present and future

Cardiac Donor Evaluation

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