Human Heart Morphogenesis: A New Vision Based on In Vivo Labeling and Cell Tracking

Villavicencio-Guzmán, Laura; Sánchez‐Gómez, Concepción; Jaime-Cruz, Ricardo; Ramírez-Fuentes, Tania Cristina; Patiño‐Morales, Carlos César; Salazar–García, Marcela

doi:10.3390/life13010165

Cited by 6 publications

(4 citation statements)

References 69 publications

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“…The embryonic development process begins with the formation of the heart, which is regulated by a group of cardiac core transcription factors. This important process is tightly controlled to ensure the proper development of this vital organ ( 40 ). Numerous previous studies have demonstrated that Nkx2.5 is regulated at the transcriptional level by many transcription factors and cis-regulatory elements upstream of the Nkx2.5.…”

Section: Transcription Regulation Of Nkx25mentioning

confidence: 99%

Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases

Cao,

Li,

Zhang

et al. 2023

Front. Cardiovasc. Med.

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Cardiomyocytes fail to regenerate after birth and respond to mitotic signals through cellular hypertrophy rather than cellular proliferation. Necrotic cardiomyocytes in the infarcted ventricular tissue are eventually replaced by fibroblasts, generating scar tissue. Cardiomyocyte loss causes localized systolic dysfunction. Therefore, achieving the regeneration of cardiomyocytes is of great significance for cardiac function and development. Heart development is a complex biological process. An integral cardiac developmental network plays a decisive role in the regeneration of cardiomyocytes. During this process, genetic epigenetic factors, transcription factors, signaling pathways and small RNAs are involved in regulating the developmental process of the heart. Cardiomyocyte-specific genes largely promote myocardial regeneration, among which the Nkx2.5 transcription factor is one of the earliest markers of cardiac progenitor cells, and the loss or overexpression of Nkx2.5 affects cardiac development and is a promising candidate factor. Nkx2.5 affects the development and function of the heart through its multiple functional domains. However, until now, the specific mechanism of Nkx2.5 in cardiac development and regeneration is not been fully understood. Therefore, this article will review the molecular structure, function and interaction regulation of Nkx2.5 to provide a new direction for cardiac development and the treatment of heart regeneration.

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Section: Transcription Regulation Of Nkx25mentioning

confidence: 99%

Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases

Cao,

Li,

Zhang

et al. 2023

Front. Cardiovasc. Med.

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“…Structurally, the heart tube contains an outer layer composed of cardiomyocytes and an inner layer comprising endothelial cells; it also has an anteriorly positioned atrial pole (outflow) and a posterior venous pole (inflow). After attaining its shape at E8.5, the linear heart tube undergoes a rightward looping process driven by uneven growth and remodeling, resulting from the recruitment of cardiac cells differentiated from progenitor cells in the SHF [10]. This event leads to the formation of primitive atria and ventricles.…”

Section: Introductionmentioning

confidence: 99%

Emerging Roles of Cullin-RING Ubiquitin Ligases in Cardiac Development

Zambrano-Carrasco,

Zou,

Wang

et al. 2024

Cells

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Heart development is a spatiotemporally regulated process that extends from the embryonic phase to postnatal stages. Disruption of this highly orchestrated process can lead to congenital heart disease or predispose the heart to cardiomyopathy or heart failure. Consequently, gaining an in-depth understanding of the molecular mechanisms governing cardiac development holds considerable promise for the development of innovative therapies for various cardiac ailments. While significant progress in uncovering novel transcriptional and epigenetic regulators of heart development has been made, the exploration of post-translational mechanisms that influence this process has lagged. Culling-RING E3 ubiquitin ligases (CRLs), the largest family of ubiquitin ligases, control the ubiquitination and degradation of ~20% of intracellular proteins. Emerging evidence has uncovered the critical roles of CRLs in the regulation of a wide range of cellular, physiological, and pathological processes. In this review, we summarize current findings on the versatile regulation of cardiac morphogenesis and maturation by CRLs and present future perspectives to advance our comprehensive understanding of how CRLs govern cardiac developmental processes.

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“…The development process of the large vessel system lasts from the third to the eighth week of gestation. [4]. Bae et al [5] proposed two distinct models of embryogenesis that can explain this system's forms.…”

Section: Introductionmentioning

confidence: 99%

Medical–Surgical Implications of Branching Variation of Human Aortic Arch Known as Bovine Aortic Arch (BAA)

Rotundu,

Nedelcu,

Tepordei

et al. 2024

JPM

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(1) Background: The aortic arch (AA) branching model is challenging, considering the multiple anatomical variations documented in existing research. The bovine aortic arch (BAA) is the most prevalent anatomical variation among these. This variant of AA branching has long been considered a nonsymptomatic malformation, having been discovered incidentally during imaging investigations for other causes. However, more recent studies have demonstrated that BAA shows a frequent association with coarctation of the aorta (CoA), thoracic aortic disease (TAD), and stroke. At the same time, given the current context of increasing activity in the fields of interventional and surgical procedures in the aorta and its branches, it is very important to know the medical–surgical implications of this anatomical variant. (2) Methods: We conducted a comprehensive review using PubMed and Embase, focusing specifically on randomized trials and cohort analyses that examined the medical–surgical implications of BAA. We assessed information related to studied groups, medical procedures, and study outcomes. Initially, we identified 8454 studies, and after rigorous evaluation, we narrowed down our review to 25 articles. (3) Discussions: The intervention consisted of assessing the risks associated with BAA through different imaging investigation methods such as computer tomographic angiography (CTA), magnetic resonance imaging (MRI), or ultrasonography (US). The following results were evaluated: the prevalence of the BAA, the importance of imaging investigations in establishing the diagnosis and the therapeutic management and monitoring the evolution of patients with the BAA, the association of the BAA with CoA, TAD, and stroke, and the potential risks of interventional treatment in patients with the BAA. (4) Conclusions: The prevalence of the BAA differs both between different ethnic groups and between genders. Advanced imaging methods such as CTA and 4D flow MRI allow detailed descriptions of supra-aortic vascular anatomy and information about blood flow velocities, direction, and turbulence in the AA. US remains an easy and valuable imaging investigation, with the potential to detect and correctly diagnose the BAA and its hemodynamic implications. Anatomical variations in the AA are associated with increased rates of TAD, CoA, and stroke, necessitating early diagnosis and increased supervision of patients with such incidentally observed abnormalities. In addition, there is a need to further develop and refine the surgical techniques used and personalize them to the individual characteristics of patients with the BAA.

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Human Heart Morphogenesis: A New Vision Based on In Vivo Labeling and Cell Tracking

Cited by 6 publications

References 69 publications

Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases

Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases

Emerging Roles of Cullin-RING Ubiquitin Ligases in Cardiac Development

Medical–Surgical Implications of Branching Variation of Human Aortic Arch Known as Bovine Aortic Arch (BAA)

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