Human health risk assessment: selected internet and world wide web resources

Patterson, Jacqueline; Hakkinen, Pertti J.; Wullenweber, Andrea

doi:10.1016/s0300-483x(02)00027-6

Cited by 24 publications

(7 citation statements)

References 11 publications

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“…Yang et al (2006a, 2006b) have recently published two such reviews. In 2001 and 2002, several review papers were published surveying the landscape of toxicity data available on the Internet (Brinkhuis 2001; Felsot 2002; Junghans et al 2002; Patterson et al 2002; Polifka and Faustman 2002; Poore et al 2001; Richard and Williams 2003; Russom 2002; Winter 2002; Wolfgang and Johnson 2002; Young 2002). …”

Section: Information Sourcesmentioning

confidence: 99%

The Toxicity Data Landscape for Environmental Chemicals

Judson

Richard

Dix

et al. 2009

Environ Health Perspect

433

282

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ObjectiveThousands of chemicals are in common use, but only a portion of them have undergone significant toxicologic evaluation, leading to the need to prioritize the remainder for targeted testing. To address this issue, the U.S. Environmental Protection Agency (EPA) and other organizations are developing chemical screening and prioritization programs. As part of these efforts, it is important to catalog, from widely dispersed sources, the toxicology information that is available. The main objective of this analysis is to define a list of environmental chemicals that are candidates for the U.S. EPA screening and prioritization process, and to catalog the available toxicology information.Data sourcesWe are developing ACToR (Aggregated Computational Toxicology Resource), which combines information for hundreds of thousands of chemicals from > 200 public sources, including the U.S. EPA, National Institutes of Health, Food and Drug Administration, corresponding agencies in Canada, Europe, and Japan, and academic sources.Data extractionACToR contains chemical structure information; physical–chemical properties; in vitro assay data; tabular in vivo data; summary toxicology calls (e.g., a statement that a chemical is considered to be a human carcinogen); and links to online toxicology summaries. Here, we use data from ACToR to assess the toxicity data landscape for environmental chemicals.Data synthesisWe show results for a set of 9,912 environmental chemicals being considered for analysis as part of the U.S. EPA ToxCast screening and prioritization program. These include high-and medium-production-volume chemicals, pesticide active and inert ingredients, and drinking water contaminants.ConclusionsApproximately two-thirds of these chemicals have at least limited toxicity summaries available. About one-quarter have been assessed in at least one highly curated toxicology evaluation database such as the U.S. EPA Toxicology Reference Database, U.S. EPA Integrated Risk Information System, and the National Toxicology Program.

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Section: Information Sourcesmentioning

confidence: 99%

The Toxicity Data Landscape for Environmental Chemicals

Judson

Richard

Dix

et al. 2009

Environ Health Perspect

433

282

View full text Add to dashboard Cite

show abstract

“…Additional information about current Web sites and Internet mailing lists of possible interest o exposure assessors, toxicologists and others is available (Patterson et al, 2002;Wexler et al, 2000) and it should be very apparent from the above examples that the Internet and Web are providing exposure assessors and others around the world with 24 h a day access to numerous valuable sources of information and opportunities for information exchange.…”

Section: The Future-broadening the Level Of Exposure Assessment Informentioning

confidence: 99%

Human exposure assessment resources on the World Wide Web

Schwela¹,

Hakkinen²

2004

Toxicology

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“…A number of studies have focused on the available commercial or free data sources. Most work deals with content analysis and advantages or disadvantages in the use of the individual databases (Patterson et al 2002; Ludl et al 1996; Frandsen & Nicolaisen 2008). In the present study we will take the bibliometric approach.…”

Section: Introductionmentioning

confidence: 99%

Identification of environmentally relevant chemicals in bibliographic databases: a comparative analysis

Ellegaard

Wallin

2013

SpringerPlus

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Valid and reliable information on the use and effects of chemicals is a key factor in the industry and not least within many regulatory agencies. Identification data from lists of substances sometimes leads to incomplete bibliographic analysis in the major chemical databases. The present study takes as its starting point environmentally important chemicals and the retrieval of selectively chosen substances in the four databases: SciFinder, Web of Science (WoS), Scopus and Google Scholar. The way chemical data are stored in the databases plays a major role in the recovery process but differences in coverage, sometimes major, are still found. No single database records all publications about a substance. Inspection of individual titles is necessary when performing a complete count of references. Special care is taken in order to make data from the different databases comparable using the same journals and time periods (2000-2009). A number of nomenclature as well as problems related to the chemical structure and function, often inherent in quantitative or qualitative bibliographic studies of chemicals, are discussed. The practical implications for registration of chemicals in different databases are demonstrated.

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Human health risk assessment: selected internet and world wide web resources

Cited by 24 publications

References 11 publications

The Toxicity Data Landscape for Environmental Chemicals

The Toxicity Data Landscape for Environmental Chemicals

Human exposure assessment resources on the World Wide Web

Identification of environmentally relevant chemicals in bibliographic databases: a comparative analysis

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