“…Although variations have been reported among all of the amino acids, substitutions of the variable l -amino acids X and Z in positions two and four are most prevalent , MC-LR is one of the most common and potent variants, which is why it has been the most widely studied. In most cases, concentrations of dissolved MCs in water are relatively small, within a range of 0.1–10 μg/L, whereas cell-bound concentrations are several orders of magnitude greater. − MCs are of concern due to their adverse effects, such as hepatotoxicity, carcinogenicity, reproductive toxicity, neurotoxicity, immunotoxicity, and endocrine-disrupting effects. , Exposure of humans to MCs can occur via ingestion of contaminated drinking water and/or consumption of cultivated plants, aquatic products including fish and blue-green algae supplements (BGAS). , In 1998, the World Health Organization (WHO) established a provisional guideline value of 1 μg MC-LR/L in drinking water. , In 2010, the International Agency for Research on Cancer (IARC) classified MC-LR as being “possibly carcinogenic to humans” (Group 2B carcinogen)…”