Human health risk assessment of bisphenol A (BPA) through meat products

Wang, Xin; Nag, Rajat; Brunton, Nigel P.; Siddique, Md. Abu Bakar; Harrison, Sabine M.; Monahan, Frank J.; Cummins, Enda

doi:10.1016/j.envres.2022.113734

Cited by 50 publications

(18 citation statements)

References 178 publications

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“…Although there are no TDI established for BPA analogues, the TDI for BPA currently set by the EFSA is 4 µg/kg body weight/day or 18 nM/kg body weight per day. 22 Recently published results from the Canadian Total Diet Study (TDS) reveal that estimated ingestion of BPS from contaminated foodstuffs, a major source of human exposure, ranged between 5.74 to 56.9 ng/kg body weight/day in the provinces of China, and exceeded that of BPA intake. 23 In a cohort of pregnant women recruited for the APrON study in Alberta, Canada, daily 24 hr intake of BPS reached up to 14 nM/kg body weight, approaching the TDI of BPA.…”

Section: Discussionmentioning

confidence: 99%

Exploring oxidative stress and endothelial dysfunction as a mechanism linking bisphenol S exposure to vascular disease in human umbilical vein endothelial cells and a mouse model of postnatal exposure

Easson

Singh

Connors

et al. 2022

Preprint

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Background: Structural analogues used to replace bisphenol A (BPA) since the introduction of new regulatory restrictions are considered emerging environmental toxicants and remain understudied with respect to their biological actions and health effects. Studies reveal a link between BPA exposure and vascular disease in human populations, whereas the vascular effects of BPA substitutes remain largely unknown. Objectives: To determine the effect of BPS, a commonly used BPA substitute, on redox balance, nitric oxide (NO) availability and microvascular NO-dependent dilation. Methods: In human umbilical vein endothelial cells (HUVEC), production of reactive oxygen species (ROS) and NO after exposure to BPS was measured using fluorescent probes for DCFDA and DAF-FM diacetate, respectively. The contribution of endothelial NO synthase (eNOS) uncoupling to ROS generation was determined by measuring ROS in the presence or absence of an eNOS inhibitor (L-NAME) or eNOS co-factor, BH4, while the contribution of mitochondria-derived ROS was determined by treating cells with mitochondria-specific antioxidants prior to BPS exposure. Bioenergetic profiles were assessed using Seahorse extracellular flux analysis and mitochondria membrane polarization was measured with TMRE and JC-1 assays. In a mouse model of low dose BPS exposure, NO-mediated endothelial function was assessed in pressurized microvessels by inducing endothelium-dependent dilation in the presence or absence of L-NAME. Results: BPS exposure (≥ 25 nM) reduced NO and increased ROS production in HUVEC, the latter corrected by treating cells with L-NAME or BH4. BPS exposure led to a loss of mitochondria membrane potential but had no impact on bioenergetic parameters except for a decrease in the spare respiratory capacity. Treatment of HUVEC with mitochondria-specific antioxidants abolished the effect of BPS on NO and ROS. NO-mediated vasodilation was impaired in male mice exposed to BPS. Discussion: Exposure to BPS may promote cardiovascular disease by perturbing NO-mediated vascular homeostasis through the induction of oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Exploring oxidative stress and endothelial dysfunction as a mechanism linking bisphenol S exposure to vascular disease in human umbilical vein endothelial cells and a mouse model of postnatal exposure

Easson

Singh

Connors

et al. 2022

Preprint

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“…The levels of ubiquitous contamination of provola cheese suggest that BPAF and BPS could result from contact with the plastic material in the machinery during the production process, and heat treatments during milk processing could have promoted the leaching of BPs into the cheese [ 37 , 38 ]. Furthermore, another likely source could be environmental contamination during the farming phase [ 39 ]. PAEs and NPPs in provolas and olive cake were determined.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Chemical Contaminants in Conventional and Unconventional Ragusana Provola Cheese

Liotta

Litrenta

Turco

et al. 2022

Foods

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Organic contaminants belonging to various classes (plasticizers, bisphenols, pesticides, PCBs, and PAHs,) were analyzed in samples of provola cheese produced from Friesian dairy cows fed with a conventional diet (group CTR), and an unconventional diet (group BIO) enriched with olive cake (OC). The results show that for most determined contaminants, the differences between the two diets were very slight, indicating that the contamination does not depend on the olive cake integrated in the unconventional diet. The results also indicate that the minimal contamination could result from environmental contamination or the production process. It can be concluded that unconventional provola is as safe for the consumer as conventional provola.

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“…Bisphenol A (BPA) has been widely used in the chemical industry and is commonly found in everyday plastic products . Researchers pointed out that BPA is one kind of endocrine disrupting chemical which can be enriched in animals, leading to reproductive disorders, various types of cancer, and chromosomal defects. − To prevent the potential health effects of BPA, efficient analysis of BPA is of key importance. The most widely used methods for BPA determination are high-performance liquid chromatography (HPLC), enzyme-linked immunosorbent assay (ELISA), and the fluorescence method .…”

Section: Introductionmentioning

confidence: 99%

Competition-Based Two-Dimensional Photonic Crystal Dually Cross-Linked Supramolecular Hydrogel for Colorimetric and Fluorescent Dual-Mode Sensing of Bisphenol A

Liu

et al. 2023

Anal. Chem.

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Bisphenol A (BPA), one of the most abundantly produced endocrine disrupting chemicals, is widely used in everyday plastic products and thus must be monitored. Multimode sensing platforms are able to combine the advantages of different strategies while solving the issues of inaccurate test results of single signal sensing. However, the exploration in this field is limited due to the compromise of sensing conditions and inevitable mutual interferences of different systems. Herein, we constructed a two-dimensional photonic crystal dually cross-linked supramolecular hydrogel (2DPCDCSH) by utilizing a host–guest pair of β-cyclodextrin (β-CD) and tert-butyl (t-Bu) as the second cross-linking for colorimetric and fluorescent dual-mode sensing of BPA. Based on the fact that BPA can act as a competitive guest to break the host–guest interaction between β-CD and t-Bu, the cross-linking density decreased and an expansion-induced structural color change occurred. Sensitive and selective BPA detection can be easily achieved by measuring the Debye diffraction ring diameter or observing the color change of 2DPC with a detection limit of 1 μg mL–1. Moreover, the formation of the β-CD/BPA complex gave a significant enhancement of the intrinsic fluorescence of BPA, obtaining a detection limit of 0.001 μg mL–1. The two sensing systems can share the same reaction condition and yield a wider dynamic response range than the single signal strategy. Overall, the proposed method presented an efficient, rapid, cost-effective, and regenerative dual-mode method for BPA analysis and shed new insights for the design of diversified sensing platforms.

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Human health risk assessment of bisphenol A (BPA) through meat products

Cited by 50 publications

References 178 publications

Exploring oxidative stress and endothelial dysfunction as a mechanism linking bisphenol S exposure to vascular disease in human umbilical vein endothelial cells and a mouse model of postnatal exposure

Exploring oxidative stress and endothelial dysfunction as a mechanism linking bisphenol S exposure to vascular disease in human umbilical vein endothelial cells and a mouse model of postnatal exposure

Evaluation of Chemical Contaminants in Conventional and Unconventional Ragusana Provola Cheese

Competition-Based Two-Dimensional Photonic Crystal Dually Cross-Linked Supramolecular Hydrogel for Colorimetric and Fluorescent Dual-Mode Sensing of Bisphenol A

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