Human Hantavirus Infections in the Netherlands

Sane, Jussi; Reimerink, Johan; Harms, Margriet; Bakker, J.; Mughini‐Gras, Lapo; Schimmer, Barbara; Pelt, Wilfrid van

doi:10.3201/eid2012.131886

Cited by 14 publications

(22 citation statements)

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“…The present seroprevalence of PUUV (0.4%; 95%CI 0.1–2.3%) is comparable to the seroprevalence estimated in the Dutch (1.7%; 95%CI 1.3–2.3%), Belgian (1.5%) and German (1–3%) general population [14–16]. The only orthohantavirus found in our study was identified as PUUV which is believed to cause the majority of human orthohantavirus infections in the Netherlands [14], and is associated with bank voles ( Myodes glareolus ). Contact with mice was less often reported by muskrat and coypu trappers than contact with rats, and could explain a similar seroprevalence as found in the general population.…”

Section: Discussionsupporting

confidence: 78%

Seroprevalence of hantaviruses andLeptospirain muskrat and coypu trappers in the Netherlands, 2016

Friesema

Bakker

Maas

et al. 2018

Infection Ecology & Epidemiology

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Aims: Seoul orthohantavirus (SEOV) and Leptospira spp. are zoonotic pathogens with rats as main reservoir. Recently, the presence of SEOV in brown rats was reported in one region in the Netherlands. Brown rats are a frequent bycatch in traps placed to catch muskrats (Ondatra zibethicus) and coypus (Myocastor coypus), and thus are a potential health risk for trappers. It was our aim to determine the seroprevalence of orthohantavirus, specifically SEOV, and Leptospira spp in Dutch trappers. Methods and results: Participating trappers provided serum samples and completed an online questionnaire. The serum was tested for the presence of antibodies against six orthohantaviruses and eight Leptospira serovars. Two hundred-sixty trappers completed the online questionnaire (65%), and 246 (61%) and 162 (40%) serum samples were tested for relevant orthohantaviruses and Leptospira spp., respectively. The seroprevalence of Puumala orthohantavirus in Dutch trappers was 0.4% (95% CI: 0.1–2.3%). None of the participants tested positive for SEOV. The seroprevalence of leptospirosis was 1.2% (95% CI: 0.3–4.4%), although Leptospira spp. are present in brown rats in the Netherlands.Significance of study: The results indicate that the infections with orthohantaviruses and leptospires is low for muskrat and coypu trappers.

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Section: Discussionsupporting

confidence: 78%

Seroprevalence of hantaviruses andLeptospirain muskrat and coypu trappers in the Netherlands, 2016

Friesema

Bakker

Maas

et al. 2018

Infection Ecology & Epidemiology

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“…The Sindbis virus (SINV) transmitted to humans from its enzootic hosts by mosquitoes, and causes polyarthritis, fever, and rash [23,24] Hantaviruses have almost entirely been associated with human contact with rodent excrement, although recent human-to-human transmission has been reported for the Andes virus in South America. Hantavirus's types cause potentially fatal diseases in humans, such as haemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome; however, others have not been associated with human disease [25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and identification of arthropod-transmitted viruses in Kassala state, Eastern Sudan

Mohamed

Magzoub

Mohamed

et al. 2019

Libyan Journal of Medicine

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Vector-borne diseases are responsible for more than 20% of the infectious diseases worldwide. The prevalence of arboviruses transmit diseases to humans in Sudan has not been investigated. Mosquito-borne viral diseases increase globally incidence, including the Sudan. Frequent unknown fever outbreaks have been reported in eastern region, Sudan. However, diagnosis was based exclusively on clinical signs and symptoms without confirmatory laboratory investigations. However, for accurate detection of these viruses in outbreaks, molecular technique is considered. The objective of this study was to determine the prevalence of six arboviruses in the Kassala state of east Sudan during unknown fever outbreak. A cross sectional hospital-based study was conducted in the Kassala, Teaching Hospital. Blood samples from 119 patients suffering from unknown fever were used for screening of six arboviruses, hepatitis E virus and malarial using molecular techniques and serology. The overall arboviruses seroprevelance was 61.3% (73/119). The highest positivity rate was 73.1% (52/73) chikungunya virus; 29 males and 20 females patients were chikungunya positive. Other arboviruses were circulating in low rate 20.5% (15/73), and 6.8% (5/73) for sindbis and rift valley fever viruses respectively. Hepatitis E virus was negative in all cases and malaria positivity rate 13.4% (16/119). The prevalence of arboviruses among unknown fever patients present to Kassala teaching hospital of eastern region in Sudan is significantly high (61.3%). The chikungunya virus is the predominant causative agent of arboviruses. Molecular techniques such as PCR are important for accurate and rapid diagnosis of this viral outbreak.

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“…Within this lineage, there was a clear geographically based clustering of the Dutch PUUV sequences; strains obtained from four locations in the region Noord-Brabant (locations B-E) clustered together but separately from the strain detected in bank voles in the Twente region (location A). Both regions are known to be endemic for NE, with most human cases reported from Twente (Goeijenbier et al, 2014;Sane et al, 2014;Schimmer, 2008). As the rodents were trapped at locations where specific human cases were residing or working, our observations indicate that these cases might …”

Section: Discussionmentioning

confidence: 99%

“…Annually, four to 24 human hantavirus cases were reported in the Netherlands in the period 2009(Sane et al, 2014, of which the majority were in the eastern and southern parts of the country, indicated in Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Puumala hantavirus in bank voles from two regions in the Netherlands where human cases occurred

Vries

Vennema

Bekker³

et al. 2016

Journal of General Virology

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Puumala hantavirus (PUUV) is the most common and widespread hantavirus in Europe and is associated with a mild form of haemorrhagic fever with renal syndrome in humans, called nephropathia epidemica. This study presents the molecular characterization of PUUV circulating in bank voles in two regions of the Netherlands. Most human cases of hantavirus infection are from these two regions. Phylogenetic analysis of the (partial) S, M and Lsegments indicated that the Dutch strains belong to the CE lineage, which includes PUUV strains from France, Germany and Belgium. We have identified two distinct groups of PUUV, corresponding with their geographic origin and with adjoining regions in neighbouring countries.

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Human Hantavirus Infections in the Netherlands

Cited by 14 publications

References 14 publications

Seroprevalence of hantaviruses andLeptospirain muskrat and coypu trappers in the Netherlands, 2016

Seroprevalence of hantaviruses andLeptospirain muskrat and coypu trappers in the Netherlands, 2016

Prevalence and identification of arthropod-transmitted viruses in Kassala state, Eastern Sudan

Characterization of Puumala hantavirus in bank voles from two regions in the Netherlands where human cases occurred

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