Human hantavirus infections: epidemiology, clinical features, pathogenesis and immunology

Manigold, Tobias; Vial, Pablo

doi:10.4414/smw.2014.13937

Cited by 99 publications

(165 citation statements)

References 82 publications

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“…Comparatively, the fatality rates in the USA, Chile, and Argentina were 35% (34) , 30% (5) , and 25.8% (27) , respectively. The differences in the fatality rates by country might be explained by the higher virulence of some hantavirus species (35) or the clinical spectrum of hantavirus disease, which ranges from a mild clinical course to cardio-respiratory failure and death (31) .…”

Section: Methodsmentioning

confidence: 99%

“…Comparatively, from 1995 to 2008 in Argentina, there were 750 HPS cases (27) , for a cumulative incidence rate of 1.955 per 100,000 inhabitants. In Chile, which is the most endemic country in the Americas, the mean incidence rate by year was 0.290 per 100,000 inhabitants, and in the USA it was 0.009 per 100,000 inhabitants (5) . During the 20 years since the 1993 Four Corners outbreak in the USA, there were 624 HPS confi rmed cases, scattered throughout 34 states (12) .…”

Section: Methodsmentioning

confidence: 99%

“…Renal failure appeared in approximately 20% of the cases registered in Brazil from 1993 to 2006 (8) . Therefore, renal failure in cases in the DF might be a late complication, similar to pre-renal acute failure (5) (31) . However, HFRS cases confi rmed in the USA (12) may also suggest the presence of this form of disease in other countries in America.…”

Section: Methodsmentioning

confidence: 99%

“…In some severe cases, the patients also had an underlying illness, such as chronic pulmonary disease (4) . Whereas 90% of HPS deaths occur within 48 hours from symptom onset (5) , the differences in the quality of care among hospitals should also be considered.…”

Section: Methodsmentioning

confidence: 99%

“…Hantavirus pulmonary syndrome (HPS) occurs in the Americas (4) (5) , while hemorrhagic fever with renal syndrome (HFRS) occurs in Europe and Asia (2) (3) (6) , with occasional reports of cross occurrence (7) .…”

Section: Introductionmentioning

confidence: 99%

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Ten years of a hantavirus disease emergency in the Federal District, Brazil

Dusi

Bredt

Freitas

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction: Hantavirus diseases are emerging human diseases caused by Hantavirus spp. of the Bunnyaviridae family. Hantavirus pulmonary syndrome (HPS) has been detected in the Federal District (DF) of Brazil since 2004. Among the 27 Brazilian Federal Units, DF has the highest fatality rate. More than 10 years have already passed since then, with confi rmation of cases caused by the Araraquara and Paranoa species. The reservoir is Necromys lasiurus. Methods: Local surveillance data of the confi rmed cases were analyzed, including age, sex, month and year of occurrence, clinical symptoms, syndromes and outcomes, and probable transmission place (PTP). The cases were mainly confi rmed by IgM detection with a capture enzyme immunoassay. The cases were classifi ed as autochthonous if PTPs were in the DF area. Results: From 2004 to 2013, in the DF, 126 cases of hantavirus were confi rmed, and the cumulative incidence was 5.0 per 100,000 inhabitants. The occurrence of cases was predominantly from April to August. At least 75% of the cases were autochthonous. Acute respiratory failure was reported in 47.5% of cases, and the fatality rate was 40%. Conclusions: In the DF, the cumulative incidence of HPS was one of the highest worldwide. A seasonal pattern of hantavirus disease in the dry season is clear. There was a high frequency of severe clinical signals and symptoms as well as a high fatality rate. For the near future, visitors and inhabitants of DF rural areas, particularly male adults, should receive continuous education about hantavirus transmission and prevention.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ten years of a hantavirus disease emergency in the Federal District, Brazil

Dusi

Bredt

Freitas

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Prediction of B Cell Epitopes Among Hantavirus Strains Causing Hemorragic Fever With Renal Syndrome

Sagadevan

Sankar

Ramamurthy

et al. 2016

J of Cellular Biochemistry

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Hantavirus infections are now recognized to be a global problem. The hantaviruses include several genotypic variants of the virus with different distributions in varying geographical regions. The virus genotypes seem to segregate in association with certain manifestations specific for each syndrome. They primarily include HFRS, HCPS, febrile illness with or without mild involvement of renal diseases. In the course of our study on hantavirus etiology of febrile illnesses, we recovered a hantavirus strain identified by nPCR. This has been sequenced to be Hantaan-like virus (partial S segment). The current manuscript is focused on understanding the N protein coded by S segment in terms of variation of amino acid sequences of the virus genotypes associated with HFRS. The diagnosis of this infection is achieved by PCR testing of serum/plasma or demonstration of IgM/IgG in serum. The limitations of PCR are temporal often not positive after 7 days of onset of infection. IgM detection is possible around this period and up to 21 days. IgG detection is less definitive in acute infections. Here, we report characterization of the sequence diversity of HFRS strains, 3D structure of Hantaan N protein, and B-cell epitopes on this molecule. We predicted a 20 amino acid sequence length peptide by using BepiPred online server in IEDB analysis resource program. We suggest this peptide may be used for development of geographic region-specific immunoassays like EIAs for antibody detection, monoclonal antibody development, and immunoblots (line immunoassay). J. Cell. Biochem. 118: 1182-1188, 2017. © 2016 Wiley Periodicals, Inc.

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Hantavirus infection in Iranian patients suspected to viral hemorrhagic fever

Salehi‐Vaziri

Kaleji

Fazlalipour

et al. 2019

Journal of Medical Virology

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Background: Hantaviruses are a group of emerging pathogens causing hemorrhagic fever with renal syndrome and Hantavirus cardiopulmonary syndrome in human. This study was conducted to investigate Hantavirus infection among Iranian viral hemorrhagic fever suspected patients. Methods: From April 2014 to June 2016, 113 cases from 25 different provinces of Iran were analyzed for Hantavirus infection by IgM/IgG ELISA and pan‐Hantavirus RT‐PCR tests. Results: Although, viral genome was detected in none of the subjects, IgM and IgG antibodies were detected in 19 and 4 cases, respectively. Differentiation of the anti‐Hantavirus antibodies according to virus species by EUROLINE Anti‐Hantavirus Profile Kit revealed three Puumala virus IgM positive, one Hantaan virus IgM positive, one Hantaan virus IgM borderline, and two Puumala virus IgG borderline cases. Conclusions: This study demonstrates the circulation of Hantaviruses in Iran and calls for further investigations of these life‐threatening viruses in the country.

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Human hantavirus infections: epidemiology, clinical features, pathogenesis and immunology

Cited by 99 publications

References 82 publications

Ten years of a hantavirus disease emergency in the Federal District, Brazil

Ten years of a hantavirus disease emergency in the Federal District, Brazil

Prediction of B Cell Epitopes Among Hantavirus Strains Causing Hemorragic Fever With Renal Syndrome

Hantavirus infection in Iranian patients suspected to viral hemorrhagic fever

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