Human gut homeostasis and regeneration: the role of the gut microbiota and its metabolites

Gómez, Claudia Marcela Arenas; García-Gutiérrez, Enriqueta; Escobar, Juan S.; Cotter, Paul D.

doi:10.1080/1040841x.2022.2142088

Cited by 8 publications

(2 citation statements)

References 189 publications

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“…Accumulating evidence points to the role of gut microbes in diseases [ 16 , 17 ], and the effectiveness of probiotics in preventing and relieving UC recurrence has been examined [ 18 , 19 , 20 ]. Most studies on probiotic microorganisms have been conducted in bacterial systems, but in recent years, some yeasts have also shown potential [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory, Barrier Maintenance, and Gut Microbiome Modulation Effects of Saccharomyces cerevisiae QHNLD8L1 on DSS-Induced Ulcerative Colitis in Mice

Zhai

et al. 2023

IJMS

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The use of probiotics has been considered as a new therapy option for ulcerative colitis (UC), and yeast has recently received widespread recommendation for human health. In this study, the probiotic characteristics of four yeast strains, Saccharomyces boulardii CNCMI-745, Kluyveromyces marxianus QHBYC4L2, Saccharomyces cerevisiae QHNLD8L1, and Debaryomyces hansenii QSCLS6L3, were evaluated in vitro; their ability to ameliorate dextran sulfate sodium (DSS)-induced colitis was investigated. Among these, S. cerevisiae QHNLD8L1 protected against colitis, which was reflected by increased body weight, colon length, histological injury relief, decreased gut inflammation markers, and intestinal barrier restoration. The abundance of the pathogenic bacteria Escherichia–Shigella and Enterococcaceae in mice with colitis decreased after S. cerevisiae QHNLD8L1 treatment. Moreover, S. cerevisiae QHNLD8L1 enriched beneficial bacteria Lactobacillus, Faecalibaculum, and Butyricimonas, enhanced carbon metabolism and fatty acid biosynthesis function, and increased short chain fatty acid (SCFAs) production. Taken together, our results indicate the great potential of S. cerevisiae QHNLD8L1 supplementation for the prevention and alleviation of UC.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory, Barrier Maintenance, and Gut Microbiome Modulation Effects of Saccharomyces cerevisiae QHNLD8L1 on DSS-Induced Ulcerative Colitis in Mice

Zhai

et al. 2023

IJMS

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“…The establishment of a causal relationship between microbiota, metabolites, and the host physiology through the use of genomics and metabolomics will facilitate the development of microbiota-targeted precision nutrition for chickens and animals, thereby improving their intestinal health and growth ( Tebani and Bekri, 2019 ; Levatte et al, 2022 ; Livingstone et al, 2022 ). Recently, omics technologies have been gaining attention as various strategies aimed at exploring and manipulating the intestinal ecosystem in order to maintain homeostasis as a healthy intestine even in challenging circumstances such as unbalanced nutrition or disease challenges ( Brugaletta et al, 2022 ; Arenas-Gómez et al, 2023 ; Urgessa and Woldesemayat, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of gut microbiota-derived carnosine on mucosal integrity and immunity in broiler chickens challenged with Eimeria maxima

Park,

Nam,

Lee

et al. 2024

Poultry Science

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On the Microstructure and Dynamics of Membranes Formed by Lipid as From Stenotrophomonas maltophilia, a Member of Gut Microbiome: An EPR Study

Vitiello,

Esposito,

Speciale

et al. 2024

Appl Magn Reson

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Lipid As are the main components of the external leaflet of the outer membrane of Gram-negative bacteria. Their molecular structure has evolved to allow the bacteria survival in specific environments. In the present work, we investigate how and to what extent lipid membranes that include in their composition lipid A molecules of a bacterium of the gut microbiota, Stenotrophomonas maltophilia, differ from those formed by the lipid A of the common Gram-negative bacterium Salmonella enterica, which is not specific to the gut and is here used as a reference. Electron Paramagnetic Resonance (EPR) spectroscopy, using spin-labelled lipids as molecular probes, allows the segmental order of the acyl chain and the polarity across the bilayer to be analyzed in detail. Both considered lipid As cause a stiffening of the outermost segments of the acyl chains. This effect increases with increasing the lipid A content and is stronger for the lipid A extracted from Stenotrophomonas maltophilia than for that extracted from Salmonella enterica. At the same time, the local polarity of the bilayer region just below the interface increases. As the inner core of the bilayer is considered, it is found that the lipid A from Salmonella enterica causes a local disorder and a significant reduction of the local polarity, an effect not found for the lipid A from Stenotrophomonas maltophilia. These results are interpreted in terms of the different lengths and distributions of the acyl tails in the two lipid As. It can be concluded that the symmetrically distributed short tails of the lipid A from Stenotrophomonas maltophilia favors a regular packing within the bilayer.

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Human gut homeostasis and regeneration: the role of the gut microbiota and its metabolites

Cited by 8 publications

References 189 publications

Anti-Inflammatory, Barrier Maintenance, and Gut Microbiome Modulation Effects of Saccharomyces cerevisiae QHNLD8L1 on DSS-Induced Ulcerative Colitis in Mice

Anti-Inflammatory, Barrier Maintenance, and Gut Microbiome Modulation Effects of Saccharomyces cerevisiae QHNLD8L1 on DSS-Induced Ulcerative Colitis in Mice

The effect of gut microbiota-derived carnosine on mucosal integrity and immunity in broiler chickens challenged with Eimeria maxima

On the Microstructure and Dynamics of Membranes Formed by Lipid as From Stenotrophomonas maltophilia, a Member of Gut Microbiome: An EPR Study

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