Human Growth Hormone Secretion after Double Stimulation with Arginine in Normal and Insulin-dependent Diabetic Women

Koncz, Lajos; Soeldner, J S; Balodimos, Marios C.; Boden, Guenther; Gleason, Ray E.; Younger, Donna

doi:10.2337/diab.22.9.694

Cited by 13 publications

(3 citation statements)

References 9 publications

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“…The same phenomenon was found by Koncz et al (18) after double stimulation with arginine in insulin-dependent diabetic women. This suggests that some cellular inability to react to a normal glucose load is present in the diabetics: whether this is the consequence of the shortage of insulin or results from a receptor cell disease is not clear.…”

Section: Discussionsupporting

confidence: 74%

Studies of Growth Hormone Secretion in Juvenile Diabetes

Locard¹,

David²,

Ruitton³

et al. 1979

Horm Res

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To further investigate the GH secretion in juvenile diabetics, blood glucose (BG) and plasma growth hormone (GH) were determined during controlled exercise performed in basal condition and under glucose infusion, in 7 controls and 22 juvenile diabetics aged 12-35 years, 10 of them with fundal vascular lesions. In controls, glucose infusion significantly lowered the exercise induced GH rise observed under basal conditions. In diabetics, under basal conditions, diabetics with low basal BG (BG < 100 mg/100 ml) had higher GH secretion than those with high basal BG (BG > 140 mg/100 ml; p < 0.05). Under glucose infusion, diabetics with normal BG peak values (not different from controls: BG = 284 ± (SD) 45 mg/l00 ml) had significantly higher plasma GH levels than controls (p < 0.01). In contrast, in diabetics with BG peak value higher than controls (BG > 374 ng/100 ml), plasma GH levels were not different from control values. This study indicates that exercise induced GH secretion in diabetics is mainly related to actual BG levels. Furthermore, we found no relation between the magnitude of GH secretion and the presence of retinopathy in diabetics.

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Section: Discussionsupporting

confidence: 74%

Studies of Growth Hormone Secretion in Juvenile Diabetes

Locard¹,

David²,

Ruitton³

et al. 1979

Horm Res

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“…The presence of hypercortisolemia prevented neither the decrease of plasma glucose values nor the GH discharge from the pituitary gland despite the known action of glucocorticoids to increase glucose production via gluconeogenesis and cause resistance to insulin action [5]. Whereas others have not found arginine infusion to be a consistent stimulus for GH secretion in monkeys [6], our data show that the infusion causes a consistent release, in fact, similar to that observed in man [9, 11, 20]. It is likely that procedural differences account for this discrepancy.…”

Section: Discussionmentioning

confidence: 47%

Hypothalamic-Adenohypophyseal Function in Male Rhesus Monkeys

Chrousos¹,

Poplack²,

Kostolich³

et al. 1981

J Med Primatol

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The secretion of six anterior pituitary hormones in both the basal state and after stimulation or suppression in nine young adult male rhesus monkeys (Macaco mulatta) was studied. Growth hormone (GH), prolactin, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) secretion were evaluated. Adrenocorticotropin hormone (ACTH) secretion was studied indirectly by measuring plasma cortisol levels. The tests were performed in combination and in sequence over a 7-hour period. Thus, multiple functions of the hypothalamic-hypophyseal axis can be studied quickly utilizing small quantities of blood.

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“…Most studies used infusion type supplements; however, four studies assessed the effect of oral supplements [ 6 , 28 , 33 , 34 , 36 ]. Twenty-one studies assessed the response of GH to ARG alone [ 6 , 8 , 11 – 13 , 28 – 30 , 32 , 34 , 36 , 38 , 44 , 50 , 53 – 55 , 62 , 63 , 65 , 66 ], and twenty-one studies investigated the response of GH to ARG + GHRH [ 6 , 8 , 31 , 33 , 35 , 37 , 40 – 43 , 47 – 49 , 52 , 56 – 59 , 61 , 67 , 68 ]. Some studies demonstrated the responsiveness of GH to combinations of ARG with other amino acids like lysine and ornithine [ 30 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

Growth Hormone Response to L-Arginine Alone and Combined with Different Doses of Growth Hormone-Releasing Hormone: A Systematic Review and Meta-Analysis

Goli

Yazdi

Heidari‐Beni

et al. 2022

International Journal of Endocrinology

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Background. Arginine (ARG) can modulate growth hormone (GH) release by suppressing its endogenous inhibitory regulator, somatostatin. ARG also induces the release of the GH-releasing hormone (GHRH). This study aims to review the effects of L-arginine supplementation alone and combined with GHRH in different doses on GH secretion. Methods. In this systematic review and meta-analysis, an electronic literature search was conducted on Medline database (PubMed), Scopus, and Web of Science databases. All eligible studies were randomized clinical trials that reported the effects of ARG supplementation alone or with GHRH on GH levels. Mean difference (MD) and 95% confidence intervals (CI) were computed as the effect size. Results. Meta-analyses showed significant effects of ARG alone on GH release (MD = 10.07, 95% CI: 7.87, 12.28). Moreover, the response of GH was greater with ARG in combination with GHRH (MD = 24.96, 95% CI: 17.51, 32.42). There was no significant difference between the patients and healthy individuals and between oral and injection use of ARG. The systematic review revealed the important role of ARG in combination with other amino acids on GH secretion in patients with GH deficiency. Conclusion. This study revealed that in GH-deficient individuals, high doses of ARG supplementation in combination with GHRH and/or other amino acids might have potential therapeutic effects on increasing GH concentrations. These findings propose that ARG supplementation can be considered as a potential stimulator in management of GH deficiency.

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Human Growth Hormone Secretion after Double Stimulation with Arginine in Normal and Insulin-dependent Diabetic Women

Cited by 13 publications

References 9 publications

Studies of Growth Hormone Secretion in Juvenile Diabetes

Studies of Growth Hormone Secretion in Juvenile Diabetes

Hypothalamic-Adenohypophyseal Function in Male Rhesus Monkeys

Growth Hormone Response to L-Arginine Alone and Combined with Different Doses of Growth Hormone-Releasing Hormone: A Systematic Review and Meta-Analysis

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