Human Growth Hormone (GH) Stimulates Erythropoietin (EPO) Secretion in Anemic Patients with Chronic Renal Failure (CRF)

Sohmiya, Motoi; Hu, Hong-Yi; Tanaka, Junko; Ishikawa, Kimiko; Murakami, Yoshio; Kato, Yuzuru

doi:10.1297/cpe.3.supple5_192

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“…It was also reported that the anemia associated with pituitary dwarfism was improved by GH replacement therapy [14]. We recently reported that GH had a stimulatory effect on EPO secretion, since GH administration for only 3 days resulted in an increase in serum EPO and the reticulocyte count in anemic patients with renal failure [15]. GH stimulates erythropoiesis in bone marrow in vivo [16] and the proliferation of erythroid progenitor cells in vitro, directly or indirectly through insulin-like growth factor I (IGF-I) [17,18].…”

Section: Discussionmentioning

confidence: 99%

A Case of Sheehan's Syndrome Associated with Severe Anemia and Empty Sella Proved 48 Years After Postpartum Hemorrhage.

et al. 1995

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Abstract. A 68-year-old woman was admitted to our hospital for severe normochromic and normocytic anemia. She had a history of prolonged postpartum hemorrhage at the age of 20 yr. Her menses were resumed thereafter and she gave birth to two other children, but her lactation was poor. She had no subjective symptom until the age of 63 yr when she complained of weakness and cold intolerance. Laboratory examination at admission revealed severe anemia (Hb 7.2 g/dl) with relatively low serum erythropoietin (EPO 20.4 mIU/ml) and panhypopituitarism.Empty sella was also found by magnetic resonance imaging (MRI). Hb levels were corrected by replacement with levothyroxine (75 µg/day) and hydrocortisone (10 mg/day), which was accompanied by an increase in serum EPO levels. These findings indicate that this is a very rare case of Sheehan's syndrome with severe anemia and empty sella proved at the longest reported interval of 48 yr after the provoking delivery, and that serum EPO levels are increased by replacement with glucocorticoid and thyroxin in panhypopituitarism.

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Section: Discussionmentioning

confidence: 99%