Human Growth Hormone: From Clone to Clinic

A Tribute to Peter H Seeburg (1944–2016): A Founding Father of Molecular Neurobiology

“…This protein was growth hormone. This work is the foundation of Peter's early scientific reputation (Seeburg, 1986). …”

Hormones

“…Modification of hydroxyprogesterone acetate (58), in particular substitution at C-6 and C-17, produced a large number of highly active oral gestagens. Some of these preparations and their trade names are listed in Table 13 (see next pages).…”

“…The polypeptides allow rapid adjustment of the serum calcium concentration to physiological reguirements. Calcitonin is a species-specific polypeptide of 32 amino acids (M r 3700); salmon and chicken calcitonin are among the most potent natural calcitonins [58]. The hormone is synthesized in the parafollicular C cells of the human thyroid gland, and in the ultimobranchial gland of several species of fish.…”

“…The extensive search for gestagens with high oral activity and low side effects started with three compounds that were more orally active than progesterone [127]: hydroxyprogesterone acetate (58), ethisterone (68), and 19-norethisterone (29), with approximately 30, 20, and 100 times the potency of progesterone, respectively. Modification of hydroxyprogesterone acetate (58), in particular substitution at C-6 and C-17, produced a large number of highly active oral gestagens.…”

Innocents suffer as rogue regime rapped

“…The expression vector is exactly as described and the bacteria make the correct hormone at the levels described in the publication. The study reported in the paper forms the basis for the first human growth hormone preparation free of neurodegenerative agents 3 , and the first recombinant therapeutic to be marketed by Genentech, from which 100,000 children benefit worldwide.…”