Human Glomerular Permeability and Tubular Recovery Values for Hemoglobin

The Renal Excretion of Hemoglobin: Regulatory Mechanisms and the Differential Excretion of Free and Protein-Bound Hemoglobin*†

“…In When these levels of free hemoglobin were added to those of the respective maximal concentrations of protein-bound hemoglobin, the estimated maximal plasma level of total hemoglobin which was attained before hemoglobin appeared in the urine varied from 124 to 180 mg. per cent (Figure 1). These levels are in agreement with previous estimates of the relationship between plasma hemoglobin (total) concentration and the development of hemoglobinuria (9).…”

“…The lower estimates of glomerular permeability made in this study are more consistent than previous estimates (9) with the molecular weight and physical characteristics of free hemoglobin (20). However, the question is unanswered as to whether the glomerulus is permeable to the free hemoglobin molecule as such or whether hemoglobin enters glomerular filtrate only after dissociating into smaller parts.…”

“…Or, expressed in another way, the concentration of free hemoglobin in glomerular filtrate averaged 5 per cent of that in plasma. The permeability of the glomerulus to hemoglobin is therefore much less than previous estimates which were made without consideration of the physicochemical state of plasma hemoglobin (9).…”

Renal Clearances of Grass Polysaccharide: Observations on Glomerular Porosity and on the Relation of This Function to Proteinuria in Renal Disease

“…with water. This gave satisfactory recoveries at plasma dilutions of [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] (b) Continuous infusion method: A small plastic catheter was placed in the femoral vein and 30 ml. of priming solution, containing usually 1 gm.…”

Urinary Hemoglobin Excretion and Renal Circulatory Dynamics: A Study of the Effect of L-Norepinephrine in the Dog 12

“…Since the concen-tration of hemoglobin in glomerular filtrate rises in a linear manner as plasma hemoglobin concentration increases (10,19), the increment in plasma concentration usually elicited in the present study by the infusion of l-norepinephrine undoubtedly contributed to this increase in transport in most studies. However, the increase in plasma level was inconstant (dogs 8 and 9) and was insufficient in most instances to account for the magnitude of the increment in the clearance of hemoglobin and in the hemoglobin-creatinine clearance ratio."…”