Human glioma tumour-associated antigens

Tribolet, Nicolas de; Carrel, Stefan

doi:10.1007/bf00200001

Cited by 14 publications

(4 citation statements)

References 37 publications

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“…Immunologically, a number of markers have been identified for human glioma cells [8]. These include glioma-associated antigens as defined by specific serum antibodies, less specific antigens detected by cell-mediated immunity, and monoclonal antibodies.…”

Section: Cellular Characteristicsmentioning

confidence: 99%

Treatment of neuroectodermal brain tumors

Shapiro

1982

Annals of Neurology

126

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Prospective clinical trials support the view that malignant neuroectodermal tumors should be treated vigorously using a multimodal approach that includes surgical resection, high-dose radiation therapy, and prolonged maintenance chemotherapy. Less malignant astrocytomas and oligodendrogliomas should be treated by resection and irradiation. Laboratory research on neuroectodermal tumors has advanced rapidly, providing new data on tumor cell biology and the pharmacology of chemotherapy that directly influence the therapeutic options.

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Section: Cellular Characteristicsmentioning

confidence: 99%

Treatment of neuroectodermal brain tumors

Shapiro

1982

Annals of Neurology

126

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“…Although there was no morphologic difference between the stained cells and their negative neighbors, by histologic criteria it seemed that HLA-DR positive cells were astrocytes [19]. In all these biopsies up to 20-30% of HLA-DR positive cells could be identified.…”

Section: Immunohistologymentioning

confidence: 76%

“…These studies have already Offprint requests to: N. de Tribolet been reviewed [19]. These studies have already Offprint requests to: N. de Tribolet been reviewed [19].…”

Section: Glioma-associated Antigensmentioning

confidence: 99%

The immunobiology of human gliomas

Piguet

Diserens

Carrel

et al. 1985

Springer Semin Immunopathol

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“…Monoclonal antibodies have been created that recognize glial antigens which are primarily displayed on gliomas and have some additional minor specificity for other non-neuroectodermal tissues and reactive astrocytes [11]. Using tissues from a large number of malignant gliomas and a panel of MAB, the overall representation of these glial antigens has been studied [10].…”

Section: Glial Antigensmentioning

confidence: 99%

Immunobiology of brain tumors

Frank¹,

Tribolet

1986

Neurosurg. Rev.

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The treatment of the cerebral glioma continues to challenge neurosurgeons and basic scientists. The lack of major success with chemotherapy and radiation therapy has spurred further investigation into the biology of this tumor and host reactions to it. Much of this research has centred upon evaluation of tumor cell antigenicity and the cellular immune responses to the glioma. Contrary to previous considerations evidence suggests that astrocytes, glioma cells and tumor endothelial cells may all have pivotal roles in the initiation and prolongation of both local and systemic immune responses to the tumor. In this review we will discuss the immunobiology of the glioma with specific reference to the interactions between the tumor and the host immune system. In addition, ideas for potential therapeutic manipulation of the host-glioma immune interactions will be reviewed stressing potential pitfalls and risks.

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Human glioma tumour-associated antigens

Cited by 14 publications

References 37 publications

Treatment of neuroectodermal brain tumors

Treatment of neuroectodermal brain tumors

The immunobiology of human gliomas

Immunobiology of brain tumors

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