Human Genome Project: Twenty-five years of big biology

Personalized Medicine, Genomics and Enhancement: Monuments to Neoliberalism

“…We have pointed to a number of the failed promises of these projects but, despite the limitations, many of the participants in these projects are convinced that the general approach was not at fault. Thus, E. D. Green, J. D. Watson, and F. S. Collins [61], when assessing the impact of the HGP, which each of the three, at one time or another directed, wrote in the "Human Genome Project: Twenty-five years of big biology," Nature News and Comments 30 September 2015, that a major legacy of the HGP is a new way of doing science.…”

A review of human genome project (HGP) from ethical perspectives

“…Interestingly, Panofsky (2015) and Wilson and Nicholls (2015) further emphasize on the potential treatment for certain multifactorial disease for example some of the cancers that most often affect women and human population health. Following this, the article entitled "Twenty-five years of big biology" by Green et al (2015) has further outlined six (6) lesson embraced from the HGP; embrace partnership, maximize data sharing, plan for data analysis, prioritize technology development, addresses the societal implications of advances and be audacious yet flexible. Meager and Lee (2016) gives full support towards this lesson insight from HGP by developing research program namely ELSI (Ethical, Legal and Social Issues) which act as an integral part of HGP.…”

“…The emergence of this field has led to ability to identify the individuals through fine samples such as saliva, hair sheets, dry blood springs or semen thus capable of solving current criminal cases (Croce, 2016). Apart from that, a new space in the field of anthropology has been introduced to identify the origins of humans, including their race, demography, genetic diseases and so on (Slatkin and Racimo, 2016;Parrington, 2015;Schiffels and Durbin, 2014;Richards and Hawley, 2010) and research on structure and function of human brain circuits (Green et al, 2015) for example the application of innovative technologies and tools to identify the brain cell types, its interconnected between different region and neurons in the brain by circuits and processing the brain signals and sensor in which has been conducted by The United States's Brain Research through Advancing Innovative Neurotechnologies (hereinafter referred to as "BRAIN"). Croce (2016) has listed five (5) advanced research on HGP namely International HAPMA Project, 1000 Genomes Project, DNA Fingerprinting, Forensic Analysis and Applied Genetic whereas Vihinen et al (2016) highlights on Human Variome Project with the defining goal is to collect all information on genetic variation that impedes human health.…”

La génomique : le pouvoir et la promesse

“…Cet effort et les initiatives postérieures de la génomique ont abouti à une percée majeure dans notre compréhen-sion de la biologie, du développement de la technologie et d'un système innovant de l' effort pour mener à bien un travail scientifique, caractérisé par une intense collaboration de plusieurs experts dans différentes disciplines dans le monde entier. Pour célébrer cet anniversaire, Eric Green, James Watson et Francis Collins ont, le 1er octobre, partagé certaines des leçons tirées de cette initiative si ambitieuse qui a transformé la façon dont est réalisée la recherche biomédicale aujourd'hui (Green et al 2015). Les résultats de cette précieuse expérience fournissent un large éventail de possibilités pour l'innovation scientifique au profit de l'humanité.…”