1999
DOI: 10.1084/jem.190.9.1241
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Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine–Mediated Chemotaxis

Abstract: TECK (thymus-expressed chemokine), a recently described CC chemokine expressed in thymus and small intestine, was found to mediate chemotaxis of human G protein–coupled receptor GPR-9-6/L1.2 transfectants. This activity was blocked by anti–GPR-9-6 monoclonal antibody (mAb) 3C3. GPR-9-6 is expressed on a subset of memory α4β7high intestinal trafficking CD4 and CD8 lymphocytes. In addition, all intestinal lamina propria and intraepithelial lymphocytes express GPR-9-6. In contrast, GPR-9-6 is not displayed on cut… Show more

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Cited by 449 publications
(417 citation statements)
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“…Interestingly, we observed that SEA pre-treated mice had an increased expression of the chemokine receptor CCR9 on their Treg population in MLN at 6 wk of age. Expression of CCR9 is imprinted on T cells primed in the Peyer's patches and the gut draining MLN, enabling migration to the gut [41][42][43]. This finding implies that the observed improvement in oral tolerance might be due to an increased recruitment of Treg to the gut.…”
Section: Discussionmentioning
confidence: 96%
“…Interestingly, we observed that SEA pre-treated mice had an increased expression of the chemokine receptor CCR9 on their Treg population in MLN at 6 wk of age. Expression of CCR9 is imprinted on T cells primed in the Peyer's patches and the gut draining MLN, enabling migration to the gut [41][42][43]. This finding implies that the observed improvement in oral tolerance might be due to an increased recruitment of Treg to the gut.…”
Section: Discussionmentioning
confidence: 96%
“…Constitutively expressed chemokines act in primary and secondary lymphoid organs [16,17,26] and peripheral tissues [27,28]. The CCR7 ligands, CCL19 and CCL21 [29,30], are expressed in the T-cell area of secondary lymphoid organs as well as on high endothelial venules (HEV) [31] and orchestrate the migration of CCR7 1 cells.…”
Section: Introductionmentioning
confidence: 99%
“…Among these homing receptors (HR), the integrin a 4 b 7 [5,6] and the chemokine receptor CCR9 [7][8][9] mediate the homing of T cell subsets to GALT such as mesenteric LN (mLN) and Peyer's patches (PP) and to the small intestinal lamina propria and the mucosal epithelium. In contrast, T cell trafficking to the skin is mediated by P-(P-lig) and E-(E-lig) selectin ligands [10,11] as well as CCR4 and CCR10 [12][13][14].…”
Section: Introductionmentioning
confidence: 99%
“…Effector T cells generated in different lymphoid organs display distinct tissue tropism, which is regulated by an organ-specific induction of adhesion molecules and chemokine receptors during T cell priming [4, [15][16][17][18][19][20][21]. For example, T cells activated in mLN and PP draining the gut acquire high levels of the integrin a 4 b 7 , whereas activation in skin-draining peripheral LN (pLN) results in the upregulation of selectin ligands such as P-lig. Tissuespecific DC have been shown in a number of in vitro and in vivo studies to be involved in the instruction of naïve T cells [4,[17][18][19][20][22][23][24].…”
Section: Introductionmentioning
confidence: 99%