In this chapter, the fundamentals of nuclear safety that the Fukushima Daiichi accident did and did not change will be discussed. While the most basic strategy of defense-in-depth principle is still valid, some problems have emerged after Fukushima, preparedness for all-hazards and multiple disasters, and importance of the administration of emergency response. From this observation, enhancing the resilience of nuclear systems is a critical issue after Fukushima. The safety enhancement measures considered in nuclear facilities will be reviewed referring to the elementary characteristics of systems resilience, and a new framework will be proposed for dealing with unsafe events, where unsafe events are classified into three categories.