Human extrahepatic portal vein obstruction correlates with decreased factor VII and protein C transcription but increased hepatocyte proliferation

Growth impairment in children with extrahepatic portal vein obstruction is improved by mesenterico-left portal vein bypass

“…portal hypertension in children with EHPVO. It is becoming clearer that these patients also have a number of metabolic disorders that include deficiencies in liver-dependent protein synthesis, suboptimal neurocognitive function, and delayed growth [11][12][13]17,[19][20][21]. Findings that point to a reversal of the metabolic derangements secondary to EHPVO after hepatic revascularization with mesenteric venous blood support the practice of early surgical intervention in these children rather than the more conservative traditional approach.…”