Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Autrup, Herman; Barile, Frank A.; Berry, Sir Colin; Blaauboer, Bas J.; Boobis, Alan R.; Bolt, Herrmann; Borgert, Christopher J.; Dekant, W.; Dietrich, Daniel R.; Domingo, José L.; Gori, Gio Batta; Greim, Helmut; Hengstler, Jan G.; Kacew, Sam; Marquardt, H; Pelkonen, Olavi; Savolainen, Kai; Heslop-Harrison, Pat; Vermeulen, Nico

doi:10.1016/j.etap.2020.103396

Cited by 2 publications

(3 citation statements)

References 40 publications

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“…However, it is important to note that human exposure to N-EDCs is many orders of magnitude greater than exposure to S-EDCs. According to Autrup, the daily intake of, or human exposure to, S-EDCs is significantly lower than exposure to N-EDCs, and the latter may pose a potential health risk [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…EDCs are highly heterogeneous and can be classified, according to their origin, as synthetic (S-EDCs) and natural (N-EDCs) [ 3 ]. S-EDCs are a broad category of man-made compounds that can be further subdivided into agricultural products such as pesticides, herbicides and fungicides, and industrial, household, and daily use products such as cosmetics, food and beverage packaging, children’s products, and textiles [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Virtuoso,

Raggi,

Maugliani

et al. 2024

Toxics

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Endocrine-disrupting compounds are chemicals that alter the normal functioning of the endocrine system of living organisms. They can be natural (N-EDCs) or synthetic compounds (S-EDCs). N-EDCs can belong to different groups, such as phytoestrogens (PEs), including flavonoids, or mycotoxins originating from plants or fungi, and cyanotoxins, derived from bacteria. Humans encounter these substances in their daily lives. The aim of this rapid review (RR) is to provide a fine mapping of N-EDCs and their toxicological effects on human health in terms of various medical conditions or adverse consequences. This work is based on an extensive literature search and follows a rigorous step-by-step approach (search strategy, analysis strategy and data extraction), to select eligible papers published between 2019 and 2023 in the PubMed database, and to define a set of aspects characterizing N-EDCs and the different human target systems. Of the N-EDCs identified in this RR, flavonoids are the most representative class. Male and female reproductive systems were the targets most affected by N-EDCs, followed by the endocrine, nervous, bone and cardiovascular systems. In addition, the perinatal, pubertal and pregnancy periods were found to be particularly susceptible to natural endocrine disruptors. Considering their current daily use, more toxicological research on N-EDCs is required.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Virtuoso,

Raggi,

Maugliani

et al. 2024

Toxics

View full text Add to dashboard Cite

show abstract

“…Assay sensitivity is another important consideration when developing an in vitro assay for endocrine disruption. Endocrine disruptors can have subtle effects on the endocrine system, and many standard cell-based assays may not be sensitive enough to detect these effects [ 20 , 21 , 22 ]. Therefore, it is important to optimize the assay conditions and endpoints to increase sensitivity and ensure that the assay can accurately detect even low levels of endocrine disruption.…”

Section: Introductionmentioning

confidence: 99%

Advancing Endocrine Disruptors via In Vitro Evaluation: Recognizing the Significance of the Organization for Economic Co-Operation and Development and United States Environmental Protection Agency Guidelines, Embracing New Assessment Methods, and the Urgent Need for a Comprehensive Battery of Tests

Fouyet,

Ferger,

Leproux

et al. 2024

Toxics

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Efforts are being made globally to improve the evaluation and understanding of endocrine-disrupting chemicals. Recognition of their impact on human health and the environment has stimulated attention and research in this field. Various stakeholders, including scientists, regulatory agencies, policymakers, and industry representatives, are collaborating to develop robust methodologies and guidelines for assessing these disruptors. A key aspect of these efforts is the development of standardized testing protocols and guidelines that aim to provide consistent and reliable methods for identifying and characterizing endocrine disruptors. When evaluating the potential endocrine-disrupting activity of chemicals, no single test is capable of detecting all relevant endocrine-disrupting agents. The test battery approach is designed to reduce the risk of false negative results for compounds with toxic potential. A weight-of-evidence approach is therefore necessary for endocrine disruptor evaluation. This approach considers various types of data from multiple sources, assessing the overall strength, consistency, and reliability of the evidence. OECD guidelines are highly regarded for their scientific rigor, transparency, and consensus-based development process. It is crucial to explore and develop new methodologies that can effectively evaluate the risks associated with potential endocrine disruptors. Integrating these methods into a comprehensive weight-of-evidence framework will enhance risk assessments and facilitate informed decisions regarding the regulation and management of these substances, ensuring the protection of human health and the environment from their adverse effects.

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Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Cited by 2 publications

References 40 publications

Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Advancing Endocrine Disruptors via In Vitro Evaluation: Recognizing the Significance of the Organization for Economic Co-Operation and Development and United States Environmental Protection Agency Guidelines, Embracing New Assessment Methods, and the Urgent Need for a Comprehensive Battery of Tests

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