Human exposure to PCBs, PBDEs and bisphenols revealed by hair analysis: A comparison between two adult female populations in China and France

Feng, Peng; Hardy, Emilie; Béranger, Rémi; Mezzache, Sakina; Bourokba, Nasrine; Bastien, Philippe; Li, Jing; Zaros, Cécile; Chevrier, Cécile; Palazzi, Paul; Sœur, Jérémie; Appenzeller, Brice

doi:10.1016/j.envpol.2020.115425

Cited by 36 publications

(24 citation statements)

References 76 publications

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“…At first, with regard to the rather short phase of applications (1 month), it cannot be excluded that more frequent daily applications would lead to more evident changes in young Chinese women. Second, it did not and could not take any account of some factors known as favoring facial skin aging such as solar exposures, [21][22][23] an aerial pollution, 24,25 a working day and associated transportation conditions induced fatigue 26 or a seasonal influence, 27,28 in a very short period of time. Third, it was designed as a pilot in consumer research agencies providing less standardized environment than a classical clinical facility to validate potentialities in term of performance detection before next experiments, which will be further conducted at home.…”

Section: Ta B L Ementioning

confidence: 99%

Comparing the self‐perceived effects of a facial anti‐aging product to those automatically detected from selfie images of Chinese women of different ages and cities

Flament

Maudet

Ye³

et al. 2021

Skin Research and Technology

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Objective: To assess the agreement, after 1-month application of a popular and efficient anti-aging product, between self-perceived facial signs of aging and those detected and graded by an automatic A.I-based system, using smartphones' selfie images.Material and Methods: Of 1065 Chinese women, aged 18-60 years, from eight different Chinese cities were recruited. They were asked to apply daily, for 1 month, a referential anti-aging product onto their whole face. Selfie images were taken by all subjects at D 0 and D 28 and sent to our facilities for being analyzed through 10 different facial signs. At D 28 , all subjects were asked to fill a questionnaire on the status of their faces, through six general statements. Results:A global agreement between both approaches is reached, particularly among women older than 40 years where the severity of facial signs is already more pronounced or among younger women who present at least facial signs scored above one grading units. This limit becomes, therefore, a prerequisite in the recruitment of Chinese subjects in the case of anti-aging applied studies and possible automatically based on automatic grading system. When respecting such conditions, the positive effects of the product on most facial signs can be demonstrated after 28 days of successive applications. Conclusion:Such methodological approach paves the road in fulfilling the need of consumers of a better transparency in the claims of an anti-aging product.

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Section: Ta B L Ementioning

confidence: 99%

Comparing the self‐perceived effects of a facial anti‐aging product to those automatically detected from selfie images of Chinese women of different ages and cities

Flament

Maudet

Ye³

et al. 2021

Skin Research and Technology

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“…(1) Pesticides, PCBs, PBDEs and bisphenols: Once the samples were dried, they were placed in a stainless grind jar for pulverization using a ball mill Retsch MM200 at 25 Hz. 50 mg of hair powder per sample were placed in a 4 ml screw neck glass vials (La-Pha-Pack) with 10 µl of internal standard solution (stable isotope labelled analogues (Hardy et al, 2015) The methodology followed was validated and fully described in Hardy et al (2015) and Beranger et al (2018), and used in previous publications (Beranger et al 2018;Iglesias-González et al 2020;Peng et al 2020bPeng et al , 2020aHardy et al 2021).…”

Section: Decontamination and Extractionmentioning

confidence: 99%

“…The limits of detection (LODs) were defined as the minimum value detected in the present study, for each biomarker, according to the approached used in previous studies (Beranger et al 2018;Iglesias-González et al 2020;Palazzi et al 2018;Peng et al 2020a). Other validation parameters (limits of quantification, accuracies, variabilities and recoveries) were fully detailed in previous articles: Beranger et al (2018), Peng et al (2020b), Hardy et al (2015), Palazzi et al (2018), Grova et al (2013).…”

Section: Quality Controls Limit Of Detection and Validation Parametersmentioning

confidence: 99%

“…Concerning organic pollutants, although the first studies only focused on persistent chemicals such as dioxins, PCBs and organochlorine pesticides, hair analysis was further along extended to many other groups of pollutants (Appenzeller and Tsatsakis 2012). Indeed, the most recent studies in the field demonstrated the possibility to detect in hair, pesticides from more than 20 different chemical families (and including hydrophilic compounds and metabolites) (Peng et al 2020a;Beranger et al 2018), bisphenols, phthalate and plasticizer metabolites (Peng et al 2020b;Fays et al 2021), as well as PAHs and their metabolites (Palazzi et al 2019(Palazzi et al , 2018. These studies were conducted on quite significant numbers of subjects and provided the first illustrations of differences in exposome between different populations.…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive Assessment of Local Population Chemical Exposome by Combination of Organic Pollutant- and Metal-Multi-Residue Analysis in Hair

et al. 2021

Self Cite

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Awareness of the adverse effects of exposure to pollutant mixtures, possibly much more severe than individual chemicals, has drawn attention towards the necessity of using multi-residue methods to obtain the most possible comprehensive information on exposome. Among the different biological matrices used for exposure assessment, hair enables to detect the largest number of chemicals, including many classes such as persistent pollutants, hydrophilic metabolites and metals. Most biomonitoring studies are however focused on a limited number of pollutants and only give a partial information on exposure. Combining several multi-residue methods, the present study aimed at assessing the exposure of a population to an extensive variety of chemicals by hair analysis. One hair sample was collected from each participant (55 children and 134 adults). Samples were analysed with three different multi-residue methods, targeting, respectively, 152 organic pollutants (pesticides, PCBs, bisphenols, PBDEs), 62 polycyclic aromatic hydrocarbons (PAHs) and metabolites, nicotine and cotinine and 36 metals. From 33 to 70 organic chemicals were detected in each child’s hair sample, and from 34 up to 74 in adults. From 7 to 26 PAH were detected per child, and 7 to 21 in adults. Twenty-three to 27 metals were detected per child and 21 to 28 per adult. The highest median concentration were observed for zinc (143 μg /mg in children; 164 μg /mg in adults), bisphenol A (95.9 pg/mg in children; 64.7 pg/mg in adults) and nicotine (66.4 pg/mg in children; 51.9 pg/mg in adults). The present study provides the most comprehensive exposure assessment ever and highlights the simultaneous exposure to multiple classes of pollutants in the general population. The results support the use of multi-residue methods for future studies on exposure-associated effects, to document exposome and better consider the effect of chemical mixtures.

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“…Enzymatic assays for the assessment of PCBs in water and food has also been applied [15] while direct sample introduction GC-MS/MS has been applied to quantify PCBs in mammalian tissue and blood [16]. In addition, human exposure to PCBs has been assessed via hair analysis in China and France [17]. PCBs have been of interest to the scientific community primarily as a result of their carcinogenic, mutagenic and teratogenic properties and potential [18].…”

Section: Introductionmentioning

confidence: 99%

Polychlorinated Biphenyls in Imported Fish

Wangboje

Okotie

2021

EJFOOD

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Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) which have been described as organohalogenic and legacy contaminants that are hazardous to both wildlife and man. The paucity of ecotoxicological data on the PCB content in commercially important fish in Benin Metropolis, Nigeria, warranted this research. In this stead, the PCB profile in the Atlantic Herring (Clupea harengus, Family: Clupeidae, mean length=31.59 cm; Mean weight=274.98 g) marketed in Benin Metropolis, was determined via Gas Chromatographic technique in order to evaluate its suitability for human consumption and to provide baseline data for this contaminant in commercially important fish species. The summary statistics for the mean concentrations of detectable PCBs in C. harengus ranged from 0.019 mg/kg (PCB 118, 156) to 0.434 mg/kg (PCB 126), with a total of 0.581 mg/kg (w/w) while the mean concentrations of PCBs in C. harengus by market ranged from 0.012 mg/kg (PCB 118) at Santana market to 0.526 mg/kg (PCB 126) at New Benin market with no observed significant difference (p>0.05) in the mean concentrations of PCBs in fish between markets. The toxicity quotient (TQ) values for PCBs in C. harengus ranged from 0.0095 (PCB 118, 156) to 0.217(PCB 126) while the estimated daily intake (EDI) values in mg/person/day for PCBs ranged from 0.00076 (PCB 118, 156) to 0.017 (PCB 126). A toxic equivalency (TEQ) value of 0.04342 while the total PCB content in C. harengus according to market ranged from 0.469 mg/kg (Santana market) to 0.658 mg/kg (Uselu market). The total toxicity of mixtures (TTM) index was 0.291. The PCB levels in fish decreased below International threshold values suggesting suitability for human consumption. Continous monitoring of this fish species for toxic concentrations of PCBs was proferred.

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Human exposure to PCBs, PBDEs and bisphenols revealed by hair analysis: A comparison between two adult female populations in China and France

Cited by 36 publications

References 76 publications

Comparing the self‐perceived effects of a facial anti‐aging product to those automatically detected from selfie images of Chinese women of different ages and cities

Comparing the self‐perceived effects of a facial anti‐aging product to those automatically detected from selfie images of Chinese women of different ages and cities

Comprehensive Assessment of Local Population Chemical Exposome by Combination of Organic Pollutant- and Metal-Multi-Residue Analysis in Hair

Polychlorinated Biphenyls in Imported Fish

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