Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems

Sifakis, Stavros; Androutsopoulos, Vasilis P.; Tsatsakis, Aristidis; Spandidos, Demetrios Α.

doi:10.1016/j.etap.2017.02.024

Cited by 349 publications

(181 citation statements)

References 140 publications

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“…Pesticides and EDs have several biological adverse effects in females as well (Petrakis et al, 2017). Most of them are related to the development of the reproductive system and are specifically attributed to folliculogenesis (Sifakis et al, 2017). The primordial follicles change to primary, pre-antral and antral follicles.…”

Section: Introductionmentioning

confidence: 99%

Association of pesticide exposure with human congenital abnormalities

Kalliora

Mamoulakis

Vasilopoulos

et al. 2018

Toxicology and Applied Pharmacology

102

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Human pesticide exposure can occur both occupationally and environmentally during manufacture and after the application of indoor and outdoor pesticides, as well as through consumption via residues in food and water. There is evidence from experimental studies that numerous pesticides, either in isolation or in combination, act as endocrine disruptors, neurodevelopmental toxicants, immunotoxicants, and carcinogens. We reviewed the international literature on this subject for the years between 1990 and 2017. The studies were considered in this review through MEDLINE and WHO resources. Out of the n = 1817 studies identified, n = 94 were reviewed because they fulfilled criteria of validity and addressed associations of interest. Epidemiological studies have provided limited evidence linking pre- and post-natal exposure to pesticides with cancers in childhood, neurological deficits, fetal death, intrauterine growth restriction, preterm birth, and congenital abnormalities (CAs). In this review, the potential association between pesticide exposure and the appearance of some human CAs (including among others musculoskeletal abnormalities; neural tube defects; urogenital and cardiovascular abnormalities) was investigated. A trend towards a positive association between environmental or occupational exposure to some pesticides and some CAs was detected, but this association remains to be substantiated. Main limitations of the review include inadequate exposure assessment and limited sample size. Adequately powered studies with precise exposure assessments such as biomonitoring, are warranted to clarify with certainty the potential association between pesticide exposure and human CAs.

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Section: Introductionmentioning

confidence: 99%

Association of pesticide exposure with human congenital abnormalities

Kalliora

Mamoulakis

Vasilopoulos

et al. 2018

Toxicology and Applied Pharmacology

102

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“…Many studies have shown that there is a correlation between male obesity and sperm count (Campbell et al, 2015; Ma et al, 2019; Ramaraju et al, 2018). Endocrine disorders, inherited, physical, or chemical factors are involved in the decline of reproductive capacity in obesity (Alves et al, 2016; Craig et al, 2017; Hayden et al, 2018; Sifakis et al, 2017). In this study, we found that adenosine accumulation in testis was a common marker in all obese mouse models.…”

Section: Discussionmentioning

confidence: 99%

“…Many epidemiological studies have shown that body mass index is negatively correlated with male reproductive potential (Campbell, Lane, Owens, & Bakos, 2015; Ma et al, 2019; Ramaraju et al, 2018). The mechanisms by which obesity causes a decline in reproductive capacity are complex, involving endocrine disorders, inherited, physical, or chemical factors (Alves et al, 2016; Craig, Jenkins, Carrell, & Hotaling, 2017; Hayden, Flannigan, & Schlegel, 2018; Sifakis, Androutsopoulos, Tsatsakis, & Spandidos, 2017). Studies have shown that testosterone is reduced in obese men and animal models, which affects spermatogenesis (Craig et al, 2017; Yabiku, Nakamoto, & Tokushige, 2018).…”

Section: Introductionmentioning

confidence: 99%

Adenosine accumulation causes metabolic disorders in testes and associates with lower testosterone level in obese mice

Yang

Zhao

Sun

et al. 2020

Molecular Reproduction Devel

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Overweight and obese men face numerous health problems, including type 2 diabetes, subfertility, and even infertility. However, few studies have focused on the effects of nutritional status and obesity‐related regulatory signals on fertility deficiency. Our previous observations have shown that the elevation of plasma 5'‐adenosine monophosphate (5'‐AMP) and the accumulation of adenosine in liver and muscle of obese diabetic db/db mice are related to insulin resistance. Here, we found that adenosine accumulation in testis is a common marker of both genetic obesity and high‐fat‐diet induced obese mice. An messenger RNA sequencing analysis indicated that 78 upregulated genes and 155 downregulated genes in the testis of 5'‐AMP‐treated mice overlapped with the same genes in the testis of ob/ob mice, and these genes belonged to the clusters of steroid metabolic process and regulation of hormone levels, respectively. Serum testosterone was reduced in ob/ob and 5'‐AMP‐treated mice. Metabolomic analysis based on 1H nuclear magnetic resonance showed that the testicular metabolic profiles of ob/ob mice were similar to those of 5'‐AMP treated mice. Exogenous 5'‐AMP inhibited the phosphorylation of AKT and mammalian target of rapamycin signal transduction and reduced the proliferating cell nuclear antigen expressions in testes. Our results suggest that the accumulation of adenosine causes metabolic disorders in testes and associates lower testosterone level in obese mice.

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“…К эндокринным дизрапторам, экзогенным веществам антропогенного происхождения, относятся различные классы химических веществ: дихлордифенилтрихлорэтан и его метаболиты, полихлорированные бифенилы, бисфенол А, полибромидные дифениловые эфиры, фталаты, пестициды, гербициды и др. [3][4][5][6][7][8][9][10][11]. Они используются в самых разных отраслях производства бытовых товаров и продуктов питания, а потому постоянно воздействуют на человека и окружающую среду [3,4,[6][7][8][9][10][11].…”

Section: современный подход к диагностике и лечению идиопатической олunclassified

Modern Approach to the Diagnosis and Treatment of Idiopathic Oligoasthenoteratozoospermia

Pochernikov¹,

Getman²

2019

EPh

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Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems

Cited by 349 publications

References 140 publications

Association of pesticide exposure with human congenital abnormalities

Association of pesticide exposure with human congenital abnormalities

Adenosine accumulation causes metabolic disorders in testes and associates with lower testosterone level in obese mice

Modern Approach to the Diagnosis and Treatment of Idiopathic Oligoasthenoteratozoospermia

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