Human Exposure to Cyanotoxins and their Effects on Health

Drobac, Damjana; Tokodi, Nada; Simeunović, Jelica; Baltic, Vladimir; Stanić, Dina; Svirčev, Zorica

doi:10.2478/10004-1254-64-2013-2320

Cited by 112 publications

(67 citation statements)

References 101 publications

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“…Furthermore, cyanotoxins can be accumulated in aquatic wildlife [17,18], and transferred to higher trophic levels [19,20]. Cyanotoxins can reach humans by different routes of exposure [21]. Fish consumers can be exposed to accumulated cyanotoxins in fish tissue [20,21].…”

Section: Introductionmentioning

confidence: 99%

Toxicopathology Induced by Microcystins and Nodularin: A Histopathological Review

Svirčev

Lujić

Marinović

et al. 2015

Journal of Environmental Science and Health, Part C

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Cyanobacteria are present in all aquatic ecosystems throughout the world. They are able to produce toxic secondary metabolites, and microcystins are those most frequently found. Research has displayed a negative influence of microcystins and closely related nodularin on fish, and various histopathological alterations have been observed in many organs of the exposed fish. The aim of this article is to summarize the present knowledge of the impact of microcystins and nodularin on the histology of fish. The observed negative effects of cyanotoxins indicate that cyanobacteria and their toxins are a relevant medical (due to irritation, acute poisoning, tumor promotion, and carcinogenesis), ecotoxicological, and economic problem that may affect both fish and fish consumers including humans.

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Section: Introductionmentioning

confidence: 99%

Toxicopathology Induced by Microcystins and Nodularin: A Histopathological Review

Svirčev

Lujić

Marinović

et al. 2015

Journal of Environmental Science and Health, Part C

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“…MCs have led to great concerns worldwide, not only for their ability to cause acute poisoning but also for the potential of promoting cancer through chronic exposure (Svirčev et al 2009;Zhou et al 2002;Drobac et al 2013). MCs can induce oxidative stress in animal cells and inhibit the activity of phosphatases 1 and 2A (PP1 and PP2A) via covalent binding to the PP catalytic subunit, which in turn causes changes of key control proteins and signaling pathways related to cytoskeleton organization and apoptosis (Komatsu et al 2007;Takumi et al 2010;Meng et al 2011;Wang et al 2014;Zeng et al 2014).…”

Section: Introductionmentioning

confidence: 99%

A review of neurotoxicity of microcystins

Chen

Fan

et al. 2016

Environ Sci Pollut Res

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Cyanobacterial blooms-produced microcystins are secondary metabolites which can accumulate in the food chain and contaminate water, thus posing a potential threat to the health of aquatic animals and even humans. Microcystin toxicity affects not only the liver but also the other organs, i.e., the brain. The serious neurotoxicity effects caused by microcystins then lead to various symptoms. This review focuses on the neurotoxicity of microcystins. Microcystins can cross bloodbrain barrier with the transport of Oatps/OATPs, causing neurostructural, functional, and behavioral changes. In this review, potential uptake mechanisms and neurotoxicity mechanisms are summarized, including neurotransmissions, neurochannels, signal transduction, oxidative stress, and cytoskeleton disruption. However, further researches are needed for detailed studies on signaling pathways and the downstream pathways of neurotoxicity of microcystins.

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“…Seperti yang telah diketahui bahwa S.platensis mengandung bahan beracun dosis kecil yaitu hepatoxin berupa microcystin dan jika dikonsumsi dalam konsentrasi berlebih maka akan berbahaya bagi tubuh manusia maupun hewan (Christawardana dan Hadiyanto, 2013). Microcystin merupakan jenis peptida siklik nonribosomal yang terkandung pada semua Cyanobacteria yang dapat menyebabkan kerusakan pada hati (Butler et al, 2009;Drobac et al, 2013). Seperti yang telah diketahui bahwa eritropoesis terjadi di dalam sumsum tulang merah (Medula osseum), hati dan limpa, sehingga kesehatan hati sangat berpengaruh terhadap proses eritropoesis.…”

Section: Gambaran Eritrositunclassified

Pengaruh perbedaan lama waktu pemberian Spirulina platensis dalam ransum terhadap profil darah merah ayam Broiler

Fahmi

Widiastuti

Sugiharto

2017

JIIP

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ABSTRAK:Penelitian ini bertujuan untuk mengkaji pengaruh lama waktu pemberian Spirulina platensis. sebagai prebiotik terhadap profil darah merah ayam broiler. Materi yang digunakan pada penelitian ini adalah 240 ekor day old chick (DOC) ayam broiler dengan bobot awal rata-rata 42,015 ± 0,219 g. Percobaan dirancang berdasar Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 5 ulangan. Perlakuan yang diterapkan yaitu T0 (Pakan Basal + 0,04% Zinc Bacitracin), T1 (Pakan Basal + 1% Spirulina platensis selama 7 hari pemberian), T2 (Pakan Basal + 1% Spirulina platensis selama 21 hari pemberian) dan T3 (Pakan Basal + 1% Spirulina platensis selama 35 hari pemberian). Variabel yang diukur meliputi total eritrosit, kadar hemoglobin, persentase hematokrit, serta nilai indeks eritrosit (MCV, MCH, MCHC). Data dianalisis dengan uji ragam (uji F) dan apabila terdapat perbedaan nyata maka dilanjutkan dengan uji wilayah ganda Duncan. Hasil penelitian menunjukkan adanya pengaruh (P<0,05) antar perlakuan terhadap rataan total eritrosit, serta tidak ada pengaruh (P>0,05) antar perlakuan terhadap kadar hemoglobin, persentase hematokrit, serta nilai indeks eritrosit (MCV, MCH, MCHC). Kesimpulan dari penelitian ini yaitu, pemberian Spirulina platensis selama 35 hari dalam ransum dapat menurunkan total eritrosit ayam broiler. Pemberian S. platensis sebagai prebiotik yang diberikan selama 7 atau 21 hari pemeliharaan memberikan hasil yang sama dengan pemberian AGPs (Antibiotics Growth Promoters) dilihat dari profil darah merah ayam broiler. Kata kunci: Sel darah merah, ayam broiler, Spirulina platensis, prebiotic ABSTRACT:The study was conducted to evaluate the effect of duration feeding of Spirulina platensis as a prebiotic in ration on the red blood cells of broiler chickens. The material used in this study was 240 day old chick (DOC) with average of initial weight 42.015 ± 0.219 g. The experiment was designed based on Completely Randomized Design (CRD) with 4 treatments and 5 replications. The treated treatments were T0 (Feed Basal + 0.04% Zinc Bacitracin), T1 (Basal diet + 1% Spirulina platensis for 7 days administration), T2 (Basal diet + 1% Spirulina platensis for 21 days of administration) and T3 (Feed Basal + 1% Spirulina platensis for 35 days of administration). Measured variables include total erythrocytes, hemoglobin, percentage of hematocrit, and erythrocyte index values (MCV, MCH, MCHC). Data were analyzed by variance test (F test) and if there was a significant difference then continued with Duncan's multiple range test. The results showed that there was significant differences (P <0.05) between treatments on total erythrocytes, and no significant differences (P> 0.05) between treatments on hemoglobin levels, hematocrit percentage, and erythrocyte index values (MCV, MCH, MCHC). It concluded that the feeding of Spirulina platensis for 35 days in ration can reduce total broiler erythrocytes and feeding S. platensis as a prebiotic given for 7 or 21 days of administration gives the same result as giving AGPs (Antibiotics Growth...

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Human Exposure to Cyanotoxins and their Effects on Health

Cited by 112 publications

References 101 publications

Toxicopathology Induced by Microcystins and Nodularin: A Histopathological Review

Toxicopathology Induced by Microcystins and Nodularin: A Histopathological Review

A review of neurotoxicity of microcystins

Pengaruh perbedaan lama waktu pemberian Spirulina platensis dalam ransum terhadap profil darah merah ayam Broiler

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