Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules

Marotta, Vincenzo; Russo, Giacomo; Gambardella, Claudio; Grasso, Marica; Sala, Domenico La; Chiofalo, Maria Grazia; D’Anna, Raffaella; Puzziello, Alessandro; Docimo, Giovanni; Masone, Stefania; Barbato, Francesco; Colao, Annamaria; Faggiano, Antongiulio

doi:10.1016/j.chemosphere.2018.11.084

Cited by 75 publications

(31 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…32 Exposure to bisphenol AF, an analogue of BPA, increases susceptibility of developing differentiated thyroid cancer in patients with thyroid nodules. 33 Direct oral administration of BPA to adult rats increased T4 levels, but, in mice, 18 BPA exposure during puberty decreased T4 levels. 34 All these results and experiments indicate that BPA could affect thyroid function, but the effects may vary according to the route, dose, duration or age at exposure.…”

Section: Discussionmentioning

confidence: 99%

Serum concentration of bisphenol A in elderly cats and its association with clinicopathological findings

Kovaříková

Maršálek

Habánová

et al. 2020

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Objectives Bisphenol A (BPA) has been mentioned as a possible factor contributing to feline hyperthyroidism. Nevertheless, there are no previous studies reporting on the concentration of BPA in feline serum and its association with thyroid function. The objectives of this study were to measure serum BPA concentration in cats aged ⩾7 years, considered as healthy by their owners, and to compare the results with clinicopathological findings. Methods Sixty-nine cats aged ⩾7 years considered as healthy by their owners were enrolled in the study. The concentration of BPA in feline serum was measured using liquid chromatography–tandem mass spectrometry. In all cats, signalment, living environment, diet history, and the results of haematological and biochemical analysis, including thyroxine levels, were available. Results The mean serum BPA concentration in feline serum was 1.06 ± 0.908 ng/ml. Significant correlation was found between BPA concentration and haemoglobin ( r = 0.3397; P = 0.0043), haematocrit ( r = 0.3245; P = 0.0065) and the number of red blood cells ( r = 0.2916; P = 0.0151), concentration of total protein ( r = 0.2383; P = 0.0486), concentration of calcium ( r = 0.3915; P = 0.0009) and level of bilirubin ( r = 0.3848; P = 0.0011). No other significant correlations were found. Significant differences ( P <0.01) were found between mature (1.28 ± 0.994 ng/ml) and geriatric cats (0.420 ± 0.240 ng/ml), between strictly indoor cats (1.27 ± 0.992 ng/ml) and cats with outdoor access (0.660 ± 0.529 ng/ml), and between cats fed canned food (1.23 ± 0.935 ng/ml) and cats fed non-canned food (0.774 ± 0.795 ng/ml). Conclusions and relevance Measurable serum BPA levels were found in all examined samples. The age of the cats was revealed as a significant factor affecting BPA concentration and mature cats had the highest levels. A significantly higher concentration of BPA was found in cats living strictly indoors and in cats fed canned food. No association was found between BPA and thyroid function. Further studies are needed that focus on hyperthyroid cats for better evaluation of this relationship.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum concentration of bisphenol A in elderly cats and its association with clinicopathological findings

Kovaříková

Maršálek

Habánová

et al. 2020

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

show abstract

“…In everyday life, humans are exposed to many chemicals that may enter the body through skin, oral, and respiratory mucosa, but mainly through the diet, causing untoward effects on the health (Lorber et al., ). Among these chemicals, some compounds, called endocrine‐disrupting chemicals (EDCs), can interfere through different mechanisms with the endocrine system, in particular with the sexual and thyroid hormone homeostasis (Marotta et al., ). Recent studies highlighted the existence of a relationship between environmental exposure to EDCs and the development of endocrine system‐related diseases, even if the detailed pathologic pathway of such disorders has not been completely unraveled yet (De Coster & van Larebeke, ).…”

Section: Introductionmentioning

confidence: 99%

Are Canned Beverages Industries Progressively Switching to Bisphenol AF?

Russo

Varriale

Barbato

et al. 2019

Journal of Food Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…Marotta et al recently found a significant dose-independent correlation between BPAF and the risk of differentiated TC in subjects with TNs. Of note, this association was not related to an increase of TSH levels, indicating a potential direct mutagenic action of BPAF on thyroid cells [161].…”

Section: Association With Thyroid Diseasesmentioning

confidence: 78%

Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence

Gorini

Bustaffa

Coi

et al. 2020

IJERPH

View full text Add to dashboard Cite

Bisphenols (BPs), and especially bisphenol A (BPA), are known endocrine disruptors (EDCs), capable of interfering with estrogen and androgen activities, as well as being suspected of other health outcomes. Given the crucial role of thyroid hormones and the increasing incidence of thyroid carcinoma in the last few decades, this review analyzes the effects of BPS on the thyroid, considering original research in vitro, in vivo, and in humans published from January 2000 to October 2019. Both in vitro and in vivo studies reported the ability of BPs to disrupt thyroid function through multiple mechanisms. The antagonism with thyroid receptors (TRs), which affects TR-mediated transcriptional activity, the direct action of BPs on gene expression at the thyroid and the pituitary level, the competitive binding with thyroid transport proteins, and the induction of toxicity in several cell lines are likely the main mechanisms leading to thyroid dysfunction. In humans, results are more contradictory, though some evidence suggests the potential of BPs in increasing the risk of thyroid nodules. A standardized methodology in toxicological studies and prospective epidemiological studies with individual exposure assessments are warranted to evaluate the pathophysiology resulting in the damage and to establish the temporal relationship between markers of exposure and long-term effects.

show abstract

Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules

Cited by 75 publications

References 97 publications

Serum concentration of bisphenol A in elderly cats and its association with clinicopathological findings

Serum concentration of bisphenol A in elderly cats and its association with clinicopathological findings

Are Canned Beverages Industries Progressively Switching to Bisphenol AF?

Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence

Contact Info

Product

Resources

About