Human exposure of bisphenol A and its analogues: understandings from human urinary excretion data and wastewater-based epidemiology

Wang, Hao; Liu, Ze‐hua; Zhang, Jun; Huang, Ri-ping; Yin, Hua; Dang, Zhi

doi:10.1007/s11356-019-07111-9

Cited by 75 publications

(32 citation statements)

References 68 publications

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“…Since BPA may affect the human body in a different way (GI tract, lungs and skin), and the degree of exposure clearly depends on various factors including not only part of the world or environmental pollution but also diet and chosen profession [41,42], the establishing the real daily exposure to this substance is relatively difficult. Nevertheless, current studies describe two methods of estimation of exposure to BPA, based on urinary excretion and wastewater-based epidemiology [104]. According to the first method, the average human exposure to BPA has been assessed at the level of 2.53 µg/day (the highest exposure in some regions amounted about 14.5 µg/day), and according to the second method-513.73 µg/day [104].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, current studies describe two methods of estimation of exposure to BPA, based on urinary excretion and wastewater-based epidemiology [104]. According to the first method, the average human exposure to BPA has been assessed at the level of 2.53 µg/day (the highest exposure in some regions amounted about 14.5 µg/day), and according to the second method-513.73 µg/day [104]. Nevertheless, on the other hand, in some cases, the daily exposure of humans to BPA may be close to, or even higher, than the dose of 0.05 mg/kg b.w./day.…”

Section: Discussionmentioning

confidence: 99%

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The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

Szymańska

Makowska

Całka

et al. 2020

IJMS

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The enteric nervous system (ENS), located in the wall of the gastrointestinal (GI) tract, is characterized by complex organization and a high degree of neurochemical diversity of neurons. One of the less known active neuronal substances found in the enteric neurons is neuregulin 1 (NRG1), a factor known to be involved in the assurance of normal development of the nervous system. During the study, made up using the double immunofluorescence technique, the presence of NRG1 in the ENS of the selected segment of porcine large intestine (caecum, ascending and descending colon) was observed in physiological conditions, as well as under the impact of low and high doses of bisphenol A (BPA) which is commonly used in the production of plastics. In control animals in all types of the enteric plexuses, the percentage of NRG1-positive neurons oscillated around 20% of all neurons. The administration of BPA caused an increase in the number of NRG1-positive neurons in all types of the enteric plexuses and in all segments of the large intestine studied. The most visible changes were noted in the inner submucous plexus of the ascending colon, where in animals treated with high doses of BPA, the percentage of NRG1-positive neurons amounted to above 45% of all neuronal cells. The mechanisms of observed changes are not entirely clear, but probably result from neurotoxic, neurodegenerative and/or proinflammatory activity of BPA and are protective and adaptive in nature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

Szymańska

Makowska

Całka

et al. 2020

IJMS

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“…Wang et al determined that exposure levels of BPA analogues vary across countries, likely a reflection of manufacturing practices or sources of exposure. Human BPS daily intake was highest in Saudi Arabia, France, and Vietnam, whereas human BPF daily intake was highest in Saudi Arabia, the Netherlands and Canada (Wang et al, 2020). Canada, the country that first restricted the use of BPA, had the lowest intake of BPA, but the highest intake of BPF (Wang et al, 2020).…”

Section: Plasticizers Bisphenolsmentioning

confidence: 98%

“…Human BPS daily intake was highest in Saudi Arabia, France, and Vietnam, whereas human BPF daily intake was highest in Saudi Arabia, the Netherlands and Canada (Wang et al, 2020). Canada, the country that first restricted the use of BPA, had the lowest intake of BPA, but the highest intake of BPF (Wang et al, 2020). While there has been extensive investigation into the health effects of BPA, relatively few studies have explored the analogues that have replaced it.…”

Section: Plasticizers Bisphenolsmentioning

confidence: 99%

Plasticizers and Cardiovascular Health: Role of Adipose Tissue Dysfunction

et al. 2021

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Since the 1950s, the production of plastics has increased 200-fold, reaching 360 million tonnes in 2019. Plasticizers, additives that modify the flexibility and rigidity of the product, are ingested as they migrate into food and beverages. Human exposure is continuous and widespread; between 75 and 97% of urine samples contain detectable levels of bisphenols and phthalates, the most common plasticizers. Concern over the toxicity of plasticizers arose in the late 1990s, largely focused around adverse developmental and reproductive effects. More recently, many studies have demonstrated that exposure to plasticizers increases the risk for obesity, type 2 diabetes, and cardiovascular disease (CVD). In the 2000s, many governments including Canada, the United States and European countries restricted the use of certain plasticizers in products targeted towards infants and children. Resultant consumer pressure motivated manufacturers to substitute plasticizers with analogues, which have been marketed as safe. However, data on the effects of these new substitutes are limited and data available to-date suggest that many exhibit similar properties to the chemicals they replaced. The adverse effects of plasticizers have largely been attributed to their endocrine disrupting properties, which modulate hormone signaling. Adipose tissue has been well-documented to be a target of the disrupting effects of both bisphenols and phthalates. Since adipose tissue function is a key determinant of cardiovascular health, adverse effects of plasticizers on adipocyte signaling and function may underlie their link to cardiovascular disease. Herein, we discuss the current evidence linking bisphenols and phthalates to obesity and CVD and consider how documented impacts of these plasticizers on adipocyte function may contribute to the development of CVD.

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“…Recently two methods of evaluation of exposure to BPA are used. According to the first of them-based on urinary excretion the average human exposure to BPA amounts to 2.53 µg/day (in regions with a high degree of environmental pollution 14.5 µg/day), and according to the second wastewater-based epidemiology method 513.73 µg/day 42 . On the other hand it is known that exposure of humans to BPA in some situations may be higher than 0.05 mg/kg b.w./day.…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone

Makowska

Lech²,

Majewski

et al. 2021

Sci Rep

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Bisphenol A (BPA) is used in the production of plastics approved for contact with feed and food. Upon entering living organisms, BPA, as a potent endocrine disruptor, negatively affects various internal organs and regulatory systems, especially in young individuals. Although previous studies have described the neurotoxic effects of BPA on various tissues, it should be underlined that the putative influence of this substance on the chemical architecture of the urinary bladder intrinsic innervation has not yet been studied. One of the most important neuronal substances involved in the regulation of urinary bladder functions is vasoactive intestinal polypeptide (VIP), which primarily participates in the regulation of muscular activity and blood flow. Therefore, this study aimed to determine the influence of various doses of BPA on the distribution pattern of VIP-positive neural structures located in the wall of the porcine urinary bladder trigone using the double-immunofluorescence method. The obtained results show that BPA influence leads to an increase in the number of both neurons and nerve fibres containing VIP in the porcine urinary bladder trigone. This may indicate that VIP participates in adaptive processes of the urinary bladder evoked by BPA.

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Human exposure of bisphenol A and its analogues: understandings from human urinary excretion data and wastewater-based epidemiology

Cited by 75 publications

References 68 publications

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

Plasticizers and Cardiovascular Health: Role of Adipose Tissue Dysfunction

Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone

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