Human Exposure Assessment and Relief From Neuropsychiatric Symptoms: Case Study of a Hairdresser

Genuis, Stephen J.; Genuis, Shelagh K.

doi:10.3122/jabfm.17.2.136

Cited by 6 publications

(3 citation statements)

References 23 publications

(17 reference statements)

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“…After recovery, she was told by several doctors that detoxification treatment was nothing more than 'placebo.' Other accounts in the medical literature also document mental health affliction in association with toxicant exposure, 29,[123][124][125] with recovery in some cases following measures to avoid or detoxify adverse chemical agents. 29,123,124…”

Section: Case History As An Example Of Chemical Detoxificationmentioning

confidence: 99%

Elimination of persistent toxicants from the human body

Genuis

2010

Hum Exp Toxicol

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There is compelling evidence that various chemical agents are important determinants of myriad health afflictions — several xenobiotics have the potential to disrupt reproductive, developmental, and neurological processes and some agents in common use have carcinogenic, epigenetic, endocrine-disrupting, and immune-altering action. Some toxicants appear to have biological effect at miniscule levels and certain chemical compounds are persistent and bioaccumulative within the human body. Despite escalating public health measures to preclude further exposures, many people throughout the world have already accrued a significant body burden of toxicants, placing them at potential health risk. As a result, increasing discussion is underway about possible interventions to facilitate elimination of persistent toxicants from the human organism in order to obviate health affliction and to potentially ameliorate chronic degenerative illness. An overview of the clinical aspects of detoxification is presented with discussion of established and emerging interventions for the elimination of persistent xenobiotics. Potential therapies to circumvent enterohepatic recirculation and a case report highlighting a clinical outcome associated with detoxification are also presented for consideration.

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Section: Case History As An Example Of Chemical Detoxificationmentioning

confidence: 99%

Elimination of persistent toxicants from the human body

Genuis

2010

Hum Exp Toxicol

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“…The clinical potential of intervening in cases of human exposure is enormous. By integrating principles of cellular metabolism and molecular medicine to address illness possibly stemming from adverse exposure, a clinical approach might include the use of recognized instruments to identify potential exposures [87,88], it might include laboratory investigations to measure levels of specific toxicants [22,89,90], it might recommend precautionary avoidance [91,92], and it might incorporate treatment protocols which endeavour to actively remove adverse influences on cellular function [89,93–97]. With an understanding of elimination mechanisms, the doctor may institute measures and therapies to mitigate cellular damage as well as maximize cellular detoxification [89,98,99] and thus potentially facilitate health restoration for the patient; neglect of cellular toxicity may result in continued ill‐health.…”

Section: The Genome–epigenome Connectionmentioning

confidence: 99%

Our genes are not our destiny: incorporating molecular medicine into clinical practice

Genuis

2008

Evaluation Clinical Practice

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In many developed nations, the state of publicly administered health care is increasingly precarious as a result of escalating numbers of chronically ill patients, inadequate medical personnel and hospital facilities, as well as sparse funding for ongoing upgrades to state-of-the-art diagnostic and therapeutic technology - an increased emphasis on aetiology-centred medicine should be considered in order to achieve improved health for patients and populations. Medical practice patterns which are designed to provide quick and effective amelioration of signs and symptoms are frequently not an enduring solution to many health afflictions and chronic disease states. Recent scientific discovery has rendered the drug-oriented algorithmic paradigm commonly found in contemporary evidence-based medicine to be a reductionist approach to clinical practice. Unfolding evidence appears to support a genetic predisposition model of health and illness rather than a fatalistic predestination construct - modifiable epigenetic and environmental factors have enormous potential to influence clinical outcomes. By understanding and applying fundamental clinical principles relating to the emerging fields of molecular medicine, nutrigenomics and human exposure assessment, doctors will be empowered to address causality of affliction when possible and achieve sustained reprieve for many suffering patients.

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“…As a result of increasing concern about environmental influences on health, ‘Human Exposure Assessment’, the investigation and study of specific patient exposures and related health concerns, is an expanding area of medical research (Ott 1995; Pope & Rall 1995; Frank 2000; Marshall 2002; Genuis & Genuis 2004). Although recommended as a routine screening tool for primary care doctors (Marshall et al .…”

Section: Current Challenges In Clinical Medicinementioning

confidence: 99%

Exploring the continuum: medical information to effective clinical practice*. Paper II. Towards aetiology‐centred clinical practice

Genuis¹,

Genuis²

2005

Evaluation Clinical Practice

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Contemporary clinical practice increasingly functions within a disease management paradigm aimed at finding and implementing therapeutic interventions that demonstrate efficacy in clinical trials. Disease prevention, elucidation of illness aetiology and proactive health promotion have taken a back seat. Current clinical care often includes a 'fast-food' type of medical encounter, which frequently neglects disease causality. The medical community is presently challenged by unique administrative and professional adversities as well as undue commercial influence; these factors contribute to a lethargic response to escalating rates of chronic illness and to mainstream medicine's relative inattention to emerging research about disease aetiology. Individual medical practitioners and the medical establishment must strategically seek to advance patient health and maintain professional relevancy by a renewed emphasis on the following principles: patient-based clinical care, aetiology-centred medicine, and proactive health promotion.

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Human Exposure Assessment and Relief From Neuropsychiatric Symptoms: Case Study of a Hairdresser

Cited by 6 publications

References 23 publications

Elimination of persistent toxicants from the human body

Elimination of persistent toxicants from the human body

Our genes are not our destiny: incorporating molecular medicine into clinical practice

Exploring the continuum: medical information to effective clinical practice*. Paper II. Towards aetiology‐centred clinical practice

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