Human ex vivo and in vitro disease models to study food allergy

Hung, Lisa; Obernolte, Helena; Sewald, Katherina; Eiwegger, Thomas

doi:10.5415/apallergy.2019.9.e4

Cited by 13 publications

(12 citation statements)

References 56 publications

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“…The BAT suggests adding significant diagnostic value to IgE-based test methods. [195][196][197] Promising results on the usage of passive sensitization strategies, mast cell lines 198 or precursors 199 have been reported.…”

Section: B I Omark Er S In Food Allergymentioning

confidence: 99%

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Breiteneder

Peng

Agache

et al. 2020

Allergy

Self Cite

156

150

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Section: B I Omark Er S In Food Allergymentioning

confidence: 99%

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Breiteneder

Peng

Agache

et al. 2020

Allergy

Self Cite

156

150

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show abstract

“…The basophil activation test has been reported to add significant diagnostic value to IgE-based test methods and clinical histories. [73][74][75] In a small number of patients (11 peanut-allergic and 14 nonallergic),…”

Section: Pbmcs Of Milk-allergic Individuals Show a Significant Downrementioning

confidence: 99%

Recent developments and highlights in food allergy

Eiwegger

Hung

Diego

et al. 2019

Allergy

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The achievement of long-lasting, safe treatments for food allergy is dependent on the understanding of the immunological basis of food allergy. Accurate diagnosis is essential for management. In recent years, data from oral food challenges have revealed that routine allergy testing is poor at predicting clinical allergy for tree nuts, almonds in particular. More advanced antigen-based tests including component-resolved diagnostics and epitope reactivity may lead to more accurate diagnosis and selection of therapeutic intervention. Additional diagnostic accuracy may come from cellular tests such as the basophil activation test or mast cell approaches. In the context of clinical trials, cellular tests have revealed specific T-cell and B-cell populations that are more abundant in food-allergic individuals with distinct mechanistic features.Awareness of clinical markers, such as the ability to eat baked forms of milk and egg, continues to inform the understanding of natural tolerance development.Mouse models have allowed for investigation into multiple mechanisms of food allergy including modification of epithelial metabolism, and the induction of regulatory cell subsets and the microbiome. Increasing numbers of children who underwent food immunotherapy enlarged the body of evidence on mechanisms and predictors of treatment success. Experimental immunological markers in conjunction with clinical determinants such as lower age and lower initial specific IgE appear to be of benefit.More research on the optimal dose, preparation, and route of application integrating a high-level safety and efficacy is demanded. Alternatively, biologics blocking TSLP, IL-33, IL-4 and IL-13, or IgE may help to achieve that. K E Y W O R D Sallergy treatment, biologics, food allergy, immune tolerance, immunotherapy | 2357 EIWEGGER Et al.

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“…The BAT suggests adding significant diagnostic value to IgE based test methods. [183][184][185] Promising results on the usage of passive sensitization strategies, mast-cell lines 186 or pre-cursors 187 have been reported.…”

Section: Biomarkers Of Viral Infections In Exacerbation Of Allergic Rmentioning

confidence: 99%

Biomarkers in the Diagnosis and Therapy of Allergic Diseases and Asthma

Breiteneder¹,

Peng²,

Agache³

et al. 2020

Preprint

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Modern healthcare requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of the distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions on the efficacy of the current management of allergic diseases requires further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen-immunotherapy with a special emphasis on specific IgE, microbiome and epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers.

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Human ex vivo and in vitro disease models to study food allergy

Cited by 13 publications

References 56 publications

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Recent developments and highlights in food allergy

Biomarkers in the Diagnosis and Therapy of Allergic Diseases and Asthma

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