Human epidemiological evidence about the associations between exposure to organochlorine chemicals and endometriosis: Systematic review and meta-analysis

Cano-Sancho, Germán; Ploteau, Stéphane; Matta, Komodo; Adoamnei, Evdochia; Louis, Germaine Buck; Mendiola, Jaime; Daraı̈, Émile; Squifflet, Jean; Bizec, Bruno Le; Antignac, Jean‐Philippe

doi:10.1016/j.envint.2018.11.065

Cited by 67 publications

(37 citation statements)

References 68 publications

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“…Evidence of estrogen mimicry, dysregulation of steroid signaling, and immune modulation by environmental toxicants such as the persistent organic pollutants including the polychlorinated biphenyls (PCBs), dioxins and dioxin like compounds, pesticides, plasticizers (phthalates and bisphenol A), and some metals has led some to hypothesize that human exposure to environmental toxicants may play an important role in reproductive health including endometriosis [3]. Although a recent systematic review and meta-analysis suggests a possible link between exposure to chlorinated organic chemicals and endometriosis [7], we postulate that the role of exposure to environmental toxicants in the pathophysiology of endometriosis remain uncertain.…”

Section: Introductionmentioning

confidence: 99%

“…Since our last review of the subject [14][15][16][17] numerous studies have emerged suggesting a potential link between environmental toxicant exposure and endometriosis [7,18]. Herein, we describe a systematic review and critical appraisal of the recent literature linking exposure to environmental toxicants and endometriosis using a modified weight-of-evidence approach to evaluate the strength of potential associations.…”

Section: Introductionmentioning

confidence: 99%

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The Link between Environmental Toxicant Exposure and Endometriosis Re-Examined

Freger¹,

Foster²

2021

Endometriosis

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Endometriosis is widely acknowledged to be an estrogen dependent disease or unknown etiology. Recognition that environmental toxicants can bind with and activate the estrogen receptor, dysregulate steroid metabolism and, in some cases, act as anti-androgenic substances (phthalate esters) has led to proposal that exposure to environmental toxicants are associated with increased risk of endometriosis. Since our last review of the subject in 2008, the literature has expanded with several epidemiological and biomonitoring studies suggesting a potential association, whereas others have been unable to demonstrate a link between exposure and enhanced risk. Therefore, we carried out a systematic review and critical appraisal of the literature published over the past decade (2009-2019). The majority of studies found dealt with exposure to polychlorinated biphenyls (PCBs), dioxins, dioxin-like and non-dioxin-like compounds, bisphenol A and phthalate esters. Several studies suggest a potential association between exposure to environmental toxicants; however, important weaknesses in study design, methodology, and analysis together with many contradictory studies weaken confidence in these associations. Consequently, we conclude that despite a growing literature, evidence for an association between exposure to environmental toxicants and risk of endometriosis remains weak.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Link between Environmental Toxicant Exposure and Endometriosis Re-Examined

Freger¹,

Foster²

2021

Endometriosis

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“…There is also substantial literature [16][17][18][19][20][21] on the effects of environmental exposure to dioxins and polychlorinated biphenyls on female reproductive health, including endometriosis. However, since these substances are banned from industrial production, and consequently occupational exposure is impossible, we decided to exclude them from this review.…”

Section: Eligibility Criteria and Study Selectionmentioning

confidence: 99%

“…Possible associations between exposure to organohalogen compounds (organochlorine pesticides [16] or perfluoroalkyls [7] in particular) or other classes of pesticides (organophosphorus, pyrethroids and phenoxy herbicides [15]) and endometriosis have been investigated. These studies confirmed the possibility that the agriculture activities may represent a risk setting in the event of exposure to a female population, due to the use of pesticide treatments based on organochlorine, organophosphorus, phenoxy herbicides or pyrethroids.…”

Section: Exposure To Organohalogen Compounds and Pesticidesmentioning

confidence: 99%

From Environmental to Possible Occupational Exposure to Risk Factors: What Role Do They Play in the Etiology of Endometriosis?

Caporossi

Capanna

Viganò

et al. 2021

IJERPH

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Endometriosis is a gynecological disorder characterized by the presence of endometrial stroma and glands outside the uterine cavity. A systematic review of the literature was conducted to clarify, starting from environmental exposure data, whether possible occupational risk factors may correlate with the onset of the disease. The guidelines for reporting systematic reviews of the “PRISMA” statement were followed and two databases, Scopus and PubMed, were used. Of the 422 studies selected with specific keywords, 32 publications were eligible, 28 of which referred to chemical agents and 4 related to night work. Conflicting data emerged among these studies. Although some compounds seemed to be more involved than others in the onset of endometriosis. Association with exposure to organochlorine compounds is the most supported by the epidemiological data, while other pesticide exposure did not show any clear correlation. Likewise, the hypothesis of a correlation with perfluoroalkyls exposure is not currently supported by data. The involvement of metals as risk factors has not been confirmed, while the role of night work, in the case of long service, seems to play an etiological role. In order to clarify the potential occupational risk of endometriosis development, well-designed studies are needed to evaluate the potential association between chemical compounds and disease etiology.

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“…Several pesticides haven been detected in surface and groundwater, as it has been described by a great number of research studies (Bortleson and Davis, 1997;Aydin et al, 2018;Xie et al, 2019). Moreover, human health is significantly affected by this kind of pollution, producing, among other problems, fertility diseases (Cano-Sancho et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Electro Fenton removal of clopyralid in soil washing effluents

et al. 2019

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The removal of a commercial herbicide, based on clopyralid, by means of Electro-Fenton (EF) was studied using a soil washing effluent obtained using synthetic ground water as washing fluid. From the results, it was observed that the degradation and mineralization yields of clopyralid were high, even without the addition of supporting electrolyte. The groundwater could be then used as a sustainable supporting electrolyte. The influence of the minerals constituents, the current and the ferrous ions regeneration was evaluated. The highest hydrogen peroxide production was achieved working at 200 mA but regeneration of ferrous ions was not efficient at this current. Iodide ions were one of the main responsible in the EF efficiency decrease due to their reaction with the produced hydrogen peroxide. Electrochemical study proved that clopyralid was not electroactive and that its degradation was mainly due to radical oxidation. Long duration electrolysis carried out at 200 mA in groundwater provided an improvement of the solution biodegradability after 480 min that can be linked to a significant increase in the carboxylic acids production. These results support the feasibility of applying an EF process in order to carry out a subsequent biological mineralization.

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Human epidemiological evidence about the associations between exposure to organochlorine chemicals and endometriosis: Systematic review and meta-analysis

Cited by 67 publications

References 68 publications

The Link between Environmental Toxicant Exposure and Endometriosis Re-Examined

The Link between Environmental Toxicant Exposure and Endometriosis Re-Examined

From Environmental to Possible Occupational Exposure to Risk Factors: What Role Do They Play in the Etiology of Endometriosis?

Electro Fenton removal of clopyralid in soil washing effluents

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