2015
DOI: 10.1093/cvr/cvv208
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Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location

Abstract: This study opens new perspectives in understanding the physiology of human EAT and its local interaction with neighbouring structures.

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Cited by 179 publications
(150 citation statements)
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“…In particular, the peri-coronary EAT resulted more closely involved in atherotic plaques formation, expressing genes involved in cell proliferation and in metabolism of sphingolipids which are lipid components of atheromas capable of promoting oxidized LDL and VLDL retention in the sub-endothelial space. In contrast, peri-ventricular EAT was more strictly linked to genes regulating inflammatory pathways, whereas the genes most up-regulated by periatrial EAT were implicated in energy metabolism, cardiomyocyte contractility and intracellular calcium signaling [64].…”
Section: Does Eat Location Matter?mentioning
confidence: 83%
“…In particular, the peri-coronary EAT resulted more closely involved in atherotic plaques formation, expressing genes involved in cell proliferation and in metabolism of sphingolipids which are lipid components of atheromas capable of promoting oxidized LDL and VLDL retention in the sub-endothelial space. In contrast, peri-ventricular EAT was more strictly linked to genes regulating inflammatory pathways, whereas the genes most up-regulated by periatrial EAT were implicated in energy metabolism, cardiomyocyte contractility and intracellular calcium signaling [64].…”
Section: Does Eat Location Matter?mentioning
confidence: 83%
“…В исследовании, проведенном во Франции в 2014 г., Gaborit B. с коллегами продемонстрировали по-вышенную экспрессию ЭЖТ генов ремоделирования экс-трацеллюлярного матрикса, кодирующих структуру коллагена IV и VI типов, тромбоспондина 3, ламини-на-α2, фибронектина 1 [24].…”
Section: фиброзunclassified
“…миокарда предсердий В эксперименте Gaborit B. с коллегами было дока-зано, что только в ЭЖТ, окружающей предсердия, на-блюдается повышение экспрессии генов окислительного фосфорилирования циклооксигеназы, АТФазы, кле-точной адгезии (ANKRD1, TNC, COL4A4) и кальциевых сигнальных путей (SERCA1, CAMK2B, CAMK2D, NCX2), что может быть связано с развитием ФП [24].…”
Section: прямое влияние на мышечную активностьunclassified
“…Of note, these biological variations are depot specific. Genome,15 16 transcriptome,17 proteome18 and mriRNome19-wide expression analyses have identified significant phenotypic differences between epicardial adipose tissue (EAT) and subcutaneous AT (SAT) in patients with CAD. Compared with SAT, EAT is characterised by higher expression of pro-inflammatory (tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin 1- β (IL1-β)), pro-oxidant (NADPH-oxidase, superoxide dismutase-2, catalase, glutathione S-transferase P, protein disulfide isomerase) and angiogenic (vascular endothelial growth factor receptor 1, endothelin 1, angiotensin II receptor 1)-regulatory genes as well as greater infiltration by immune cells, particularly M1 proinflammatory macrophages 16 18 20.…”
Section: Introductionmentioning
confidence: 99%