Human epicardial adipose tissue-derived and circulating secreted frizzled-related protein 4 (SFRP4) levels are increased in patients with coronary artery disease

Ji, Qingwei; Zhang, Jianwei; Du, Yu; Zhu, Enjun; Wang, Zhijian; Que, Bin; Miao, Heng; Shi, Shutian; Qin, Xiuchuan; Zhao, Yingxin; Zhou, Yujie; Huang, Fangjun; Nie, Shaoping

doi:10.1186/s12933-017-0612-9

Cited by 31 publications

(23 citation statements)

References 38 publications

(57 reference statements)

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“…CAD was an independent predictor of the increased plasma SFRP-4 levels. All results, including our results, suggest that SFRP-4 is a novel biomarker of CAD and might play a role in the development of CAD and DM due to the fact that SFRP-4 was up-regulated in patients with T2DM (15,(22)(23)(24)(25)(26)(27)(28).…”

Section: Discussionsupporting

confidence: 60%

“…Comparison of event-free survival between SFRP-4 tertiles showed that SFRP-4 levels were not predictive for cardiovascular outcome in patients with stable CAD on treatment. Ji et al (24) found that plasma SFRP-4 levels were increased in CAD patients compared to non-CAD patients. Our results are similar; plasma SFRP-4 levels were positively correlated with BMI, fasting insulin levels and HOMA-IR values.…”

Section: Discussionmentioning

confidence: 99%

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The relationship between carotid intima-media thickness and serum secreted frizzled-related protein-4 and dipeptidyl peptidase-4 in diabetic patients with cardiovascular diseases

Şenyiğit¹,

Uzun²,

Gültepe³

et al. 2019

BLL

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We investigated the association between carotid intima-media thickness (CIMT) with clusterin (CLU), amylin, secreted frizzled-related protein-4 (SFRP-4), glucagon-like peptide-1 (GLP-1) levels, and dipeptidyl peptidase-4 (DPP-4) in type 2 diabetes mellitus (T2DM) individuals with or without coronary artery disease (CAD). This study consisted of four groups: control group (mean ages: 50.3±10.7 years; 20 females and 15 males), diabetic group (DM; mean ages: 53.9±11.1; 14 females and 23 males), CAD group (mean ages: 60.1±43.5; 17 females and 17 males) and CAD+DM group (mean ages: 62.6±11.8 years; 18 females and 18 males). CIMT levels in both CAD and CAD+DM groups are higher than those in controls. CIMT levels in CAD+DM group are also signifi cantly higher than those in DM group. Left external carotid artery (ECA) was found different from controls only in DM group. The levels of SFRP-4 in control group were signifi cantly lower than those in DM, CAD and CAD+DM groups. Serum GLP-1 total levels were found to be signifi cantly low in CAD+DM group when compared to control group. DPP-4 and SFRP-4 levels may be a predictive marker for atherosclerosis in diabetes while particularly in diabetes, they correlate well with HOMA-IR. CIMT has the potential to be a clinically useful predictor of vascular risk in diabetic patients with CAD (Tab. 3, Fig. 2, Ref. 39). Text in PDF www.elis.sk. KEY WORDS: type 2 diabetes mellitus, carotid intima-media thickness, glucagon-like peptide-1, dipeptidyl peptidase-4, clusterin, amylin, secreted frizzled-related protein-4.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

The relationship between carotid intima-media thickness and serum secreted frizzled-related protein-4 and dipeptidyl peptidase-4 in diabetic patients with cardiovascular diseases

Şenyiğit¹,

Uzun²,

Gültepe³

et al. 2019

BLL

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“…In the previous study, we showed that EAT-derived and circulating secreted frizzled-related protein 4 (SFRP4) expression levels are increased in patients with CAD and in epicardial adipocytes of CAD patients, the concentrations of leptin, tumor necrosis factor-α, and IL-1, were higher, while the levels of adiponectin, IL-10, and FGF-β were lower than those in subcutaneous adipocytes [ 23 , 24 ]. Bouchi et al showed that sodium-glucose co-transporter-2 (SGLT2) inhibitors could reduce the epicardial fat volume and reduce the secretion of pro-inflammatory chemokines [ 25 – 27 ].…”

Section: Discussionmentioning

confidence: 99%

Relationships between epicardial adipose tissue thickness and adipo-fibrokine indicator profiles post-myocardial infarction

Груздева

Uchasova

Dyleva

et al. 2018

Cardiovasc Diabetol

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BackgroundDetermination of the impact of visceral obesity and epicardial adipose tissue thickness on stimulating growth factor levels during hospitalization for myocardial infarction is of potential importance for predicting outcomes and assessing the development of cardiofibrotic changes associated with maladaptive myocardial remodeling. In this study, we aimed to investigate the relationships between epicardial adipose tissue thickness, adipokine profiles, and the stimulating growth factor 2/interleukin-33 signaling system during hospitalization for myocardial infarction, and with the cardiac fibrosis extent 1-year post-MI in patients with visceral obesity.MethodsEighty-eight patients with myocardial infarction were grouped based on their visceral obesity. Serum leptin, adiponectin, stimulating growth factor 2, and interleukin-33 levels were measured on days 1 and 12 and at 1 year. The epicardial adipose tissue widths and the cardiac fibrosis areas were measured on day 12 and at 1 year.ResultsVisceral obesity was associated with epicardial adipose tissue thickness increases, adipokine imbalances, elevated leptin levels, and lower adiponectin levels during early hospitalization, and cardiac fibrosis development. Patients without visceral obesity had higher interleukin-33 and stimulating growth factor 2 levels during early hospitalization and lower cardiac fibrosis rates. Epicardial adipose tissue thickness was positively associated with cardiac fibrosis prevalence and interleukin-33 levels and negatively associated with stimulating growth factor 2 levels. The cardiac fibrosis extent was negatively associated with interleukin-33 levels and positively associated with stimulating growth factor 2 levels.ConclusionsIncreases in epicardial adipose tissue thickness are associated with cardiac fibrosis development 1-year post-myocardial infarction and are higher in patients with visceral obesity. The metabolic activity of the epicardial adipose tissue is associated with elevated interleukin-33 and reduced stimulating growth factor 2 levels.

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“…Our study indicates that DM patients have more EFT than non-DM patients, and this provides new ideas for the diagnosis and treatment of DM in the future and research into DM performed in the future. EFT is closely related to the occurrence of CHD [63,64]. The difference in EFT between DM patients and non-DM patients may have an important relationship with the incidence of cardiovascular diseases, but whether EFT can be used to assess the risk of cardiovascular diseases in DM patients at an early stage needs to be confirmed by further studies.…”

Section: Future Directionsmentioning

confidence: 99%

Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis

Liu

et al. 2019

Cardiovasc Diabetol

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Background: Epicardial fat tissue (EFT) is the visceral fat distributed along the coronary arteries between the pericardium and the myocardium. Increases in EFT are closely related to the occurrence of diabetes mellitus (DM) and cardiovascular disease. To further understand the link between EFT and DM, we conducted a meta-analysis of the relevant literature. Methods: We systematically searched electronic databases for studies on EFT performed in DM patients and published up to 30 September 2018. We included data on EFT in a DM patient group and a non-DM control group. We then assessed the effect of DM on EFT by meta-analysis and trial sequential analysis (TSA). All statistical analyses were performed using Stata 12.0 and TSA software. Results: A total of 13 studies (n = 1102 patients) were included in the final analysis. Compared with the control group, DM patients had significantly higher EFT (SMD: 1.23; 95% CI 0.98, 1.48; P = 0.000; TSA-adjusted 95% CI 0.91, 2.13; P < 0.0001). The TSA indicated that the available samples were sufficient and confirmed that firm evidence was reached. According to the regression analysis and subgroup analyses, DM typing, EFT ultrasound measurements, total cholesterol (TC) and triglyceride (TG) levels were confounding factors that significantly affected our results. Conclusions: Our meta-analysis suggests that the amount of EFT is significantly higher in DM patients than in non-DM patients.

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Human epicardial adipose tissue-derived and circulating secreted frizzled-related protein 4 (SFRP4) levels are increased in patients with coronary artery disease

Cited by 31 publications

References 38 publications

The relationship between carotid intima-media thickness and serum secreted frizzled-related protein-4 and dipeptidyl peptidase-4 in diabetic patients with cardiovascular diseases

The relationship between carotid intima-media thickness and serum secreted frizzled-related protein-4 and dipeptidyl peptidase-4 in diabetic patients with cardiovascular diseases

Relationships between epicardial adipose tissue thickness and adipo-fibrokine indicator profiles post-myocardial infarction

Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis

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