Human endometrial stem cells: High-yield isolation and characterization

An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2

“…Recently, Kovina et al 21 isolated and characterized menstrual bloodderived human endometrial stem cells that retained their ability to differentiate into multiple lineages. The isolation and characterization of endometrial stem cells from human endometrium were performed using a modification of their procedures.…”

Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice

“…Good effect in elderly patients was demonstrated recently with allogeneic mesenchymal stem cells, and a clinical trial has started (Tompkins et al, 2017). The richest source of highly proliferative mesenchymal stem cells is menstrual blood (Kovina et al, 2018). Since not only freshly isolated but also cryopreserved SCs could be effective, the cryobanking of bone marrow SCs, cord blood SCs, and menstrual SCs would eliminate the shortage of histocompatible donor SCs.…”

Cellular therapies for the endometrium: An update

“…Extensive work has been performed to delineate and characterize specific stem cell and pericyte populations within the endometrial stromal compartment . These cells can be isolated from endometrial biopsies obtained during the proliferative phase (cycle day [CD]5‐CD14) or extracted from menstruate (CD28‐CD4) …”

“…15 These cells can be isolated from endometrial biopsies obtained during the proliferative phase (cycle day [CD]5-CD14) or extracted from menstruate (CD28-CD4). 16 Although in their infancy, pilot clinical trials with endometrialderived stromal cell sources have proven safety and potential efficacy. Tan et al 6 delivered in vitro expanded autologous menSCs to a cohort of 7 women with severe AS.…”