Human Endogenous Retroviruses-K (HML-2) Expression Is Correlated with Prognosis and Progress of Hepatocellular Carcinoma

Ma, Weijie; Hong, Zhenfei; Liu, Hailing; Chen, Xi; Ding, Liang; Liu, Zhisu; Zhou, Fuling; Yuan, Yufeng

doi:10.1155/2016/8201642

Cited by 56 publications

(64 citation statements)

References 45 publications

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“…For instance, HERV-K expression has been correlated with the prognosis and progress of hepatocellular carcinoma [ 23 ], and is strictly required to sustain CD133 + melanoma cells with stemness features [ 17 ]. Recently, it was reported that activation of HERV-K envelope protein is essential to tumorigenesis and metastasis formation in breast cancer [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, some of them seem to contribute to cancer development and some mechanisms of action have been proposed [ 6 , 7 , 17 , 20 ]. For instance, HERV-K expression is correlated with the prognosis and progress of hepatocellular carcinoma [ 23 ]. HERV-K activation is strictly required to sustain CD133 + melanoma cells with stemness features [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic stress induces transfer of mitochondria-associated human endogenous retroviral RNA and proteins between cancer cells

et al. 2017

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About 8 % of the human genome consists of human endogenous retroviruses (HERVs), which are relicts of ancient exogenous retroviral infections incurred during evolution. Although the majority of HERVs have functional gene defects or epigenetic modifications, many of them are still able to produce retroviral proteins that have been proposed to be involved in cellular transformation and cancer development.We found that, in chemo-resistant U87RETO glioblastoma cells, cytotoxic stress induced by etoposide promotes accumulation and large-scale fission of mitochondria, associated with the detection of HERV-WE1 (syncytin-1) and HERV-FRD1 (syncytin-2) in these organelles. In addition, mitochondrial preparations also contained the corresponding receptors, i.e. ASCT2 and MFSD2. We clearly demonstrated that mitochondria associated with HERV-proteins were shuttled between adjacent cancer cells not only via tunneling tubes, but also by direct cellular uptake across the cell membrane. Furthermore, anti-syncytin-1 and anti-syncytin-2 antibodies were able to specifically block this direct cellular uptake of mitochondria even more than antibodies targeting the cognate receptors.Here, we suggest that the association of mitochondria with syncytin-1/syncytin-2 together with their respective receptors could represent a novel mechanism of cell-to-cell transfer. In chemotherapy-refractory cancer cells, this might open up attractive avenues to novel mitochondria-targeting therapies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytotoxic stress induces transfer of mitochondria-associated human endogenous retroviral RNA and proteins between cancer cells

et al. 2017

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“…[11,12] In recent years, the link between Lp-PLA2 gene polymorphism and stroke, particularly ischemic stroke, is investigated in several studies. [13] Hiramoto et al [14] have reported that Lp-PLA2 V279F gene polymorphism is a genetic risk factor for stroke. Li and Ye [15] have reported that Lp-PLA2 A379V gene polymorphism is significantly correlated with ischemic stroke and genotype CC is a risk factor for such disease.…”

Section: Introductionmentioning

confidence: 99%

Association of Lp‐PLA2 G994T gene polymorphism with risk of ischemic stroke in Chinese population

Ni¹,

Gu²,

Hu³

et al. 2017

J Biochem & Molecular Tox

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The association between lipoprotein-associated phospholipase A2 (Lp-PLA2) G994T gene polymorphism and the risk of ischemic stroke is unclear. The aim of this study is to investigate the influence of Lp-PLA2 G994T genetic variant on the pathogenesis of ischemic stroke in Chinese population. A total of 348 patients with a clinical diagnosis of ischemic stroke and 260 gender-matched control subjects under physical examination were recruited from hospitals and genotyped for G994T gene polymorphism. The results showed that there was a significant difference in the genotype distribution between the two groups and people with GT or TT genotype were associated with the higher risk of ischemic stroke even after adjusting the effects of potential confounding factors. In addition, both ischemic stroke patients and control subjects carrying T allele showed relatively lower Lp-PLA2 activity and higher oxLDL level. Therefore, Lp-PLA2 G994T gene polymorphism may be an independent risk factor of ischemic stroke in Chinese population.

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“…Of the three patients with RNA-seq data, only one patient showed a subfamily-level change in expression. This was linked to an increase in HERV activity, which previous studies have reported for HERV-K in various cancers (Wallace et al 2014;Ma et al 2016). We were also able to examine the expression of specific mobile element loci in which there were informative reads.…”

Section: Discussionmentioning

confidence: 71%

Mobile Element Insertions and Associated Structural Variants in Longitudinal Breast Cancer Samples

Steely

Russell

Feusier

et al. 2020

Preprint

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While mobile elements are largely inactive in healthy somatic tissues, increased activity has been found in cancer tissues, with significant variation among different cancer types. In addition to insertion events, mobile elements have also been found to mediate many structural variation events in the genome. Here, to better understand the timing and impact of mobile element insertions and mobile element-mediated structural variants in cancer, we examined their activity in longitudinal samples of four metastatic breast cancer patients. With whole-genome sequencing data from multiple timepoints through tumor treatment and progression, we used mobile element detection software followed by visual confirmation of the insertions. From this analysis we identified 11 mobile element insertions or mobile element-mediated structural variants, and found that the majority (nine of the eleven) of these occurred early in tumor progression. Two of the identified insertions were SVA elements, which have not been examined in previous cancer studies. Most of the variants appear to impact intergenic regions; however, we identified a mobile element-mediated translocation in MAP2K4 and a mobile element-mediated deletion in YTHDF2 that likely inactivate reported tumor suppressor genes. MAP2K4 is part of the JNK signaling pathway, influencing cell growth and proliferation. The high variant allele frequency of this translocation and the important function of MAP2K4 indicate that this mobile element-mediated translocation is likely a driver mutation.

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Human Endogenous Retroviruses-K (HML-2) Expression Is Correlated with Prognosis and Progress of Hepatocellular Carcinoma

Cited by 56 publications

References 45 publications

Cytotoxic stress induces transfer of mitochondria-associated human endogenous retroviral RNA and proteins between cancer cells

Cytotoxic stress induces transfer of mitochondria-associated human endogenous retroviral RNA and proteins between cancer cells

Association of Lp‐PLA2 G994T gene polymorphism with risk of ischemic stroke in Chinese population

Mobile Element Insertions and Associated Structural Variants in Longitudinal Breast Cancer Samples

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