Human dorsal root ganglion pulsed radiofrequency treatment modulates cerebrospinal fluid lymphocytes and neuroinflammatory markers in chronic radicular pain

Das, Basabjit; Conroy, Melissa J.; Moore, David; Lysaght, Joanne; McCrory, Connail

doi:10.1016/j.bbi.2018.02.010

Cited by 33 publications

(28 citation statements)

References 24 publications

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“…PRF can regulate the expression of multiple genes in the conduction pathway, enhancing the expression of anti-inflammatory factor genes (GABAB-R1, Na/KATPase, and 5-HT3r) in the dorsal root ganglion, while decreasing the expression of proinflammatory factor genes (TNF-α and IL-6) (Vallejo et al, 2013). PRF has an immunoregulation effect, which has been shown to significantly reduce the level of CD56 + , CD3 - , IFN-γ, and NK cell frequency, and increase CD8 + T cell frequency and IL-6 in cerebrospinal fluid (Das et al, 2018). PRF has been shown to upregulate the transcription and translation of glial cell line-derived neurotrophic factor (GDNF) in the sciatic nerve and spinal cord (Jia et al, 2016; Hailong et al, 2018) and reduce calcitonin gene-related peptide (CGRP) expression in dorsal root ganglion (Ren et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

CT-Guided Stellate Ganglion Pulsed Radiofrequency Stimulation for Facial and Upper Limb Postherpetic Neuralgia

Ding

Yao

et al. 2019

Front. Neurosci.

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Objective: Postherpetic neuralgia (PHN) is the most common complication of herpes zoster, manifesting as a persistent, spontaneous, knife-like pain or paroxysmal burning that seriously affects a patient’s quality of life. An effective treatment of PHN is lacking. This retrospective study examined the efficacy and safety of stellate ganglion (SG) pulsed radiofrequency (PRF) on facial and upper limb PHN.Methods: Eighty-four patients with PHN on the face or upper limbs were enrolled for the study. Patients were randomly divided into two surgical groups according to the order of enrollment; one group underwent SG block (SG-B group, n = 42) and the other underwent SG pulsed radiofrequency (SG-P group, n = 42). After surgery, patients were followed at 1 week, 2 weeks, 1 month, 3 months, and 6 months. Observation at each follow-up included basic patient characteristics, visual analog scale (VAS), quality of life (QOL) using Physical Component Summary (PCS), and Mental Component Summary (MCS) to assess, total effective rate, complications and side effects.Results: Compared with preoperative values, VAS decreased in both groups after surgery (P < 0.05). In the SG-B group, VAS increased after 1 month, while in the SG-P group, VAS gradually decreased at later follow-up time points. VAS decreased more significantly in the SG-P group after 1 month (P < 0.05). PCS and MCS increased in both groups after the operation, and the difference was significant compared with preoperative values (P < 0.05). The total effective rates of the SG-B and SG-P groups were 64.3 and 83.3%, respectively. The total effective rate of the SG-P group was higher than that of the SG-B group (P < 0.05). The incidence of complications and side effects in the SG-B group was higher than that in the SG-P group (P < 0.05).Conclusion: SG pulsed radiofrequency treatment of facial and upper limb PHN is safe and effective. It is a treatment method worth promoting.

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Section: Discussionmentioning

confidence: 99%

CT-Guided Stellate Ganglion Pulsed Radiofrequency Stimulation for Facial and Upper Limb Postherpetic Neuralgia

Ding

Yao

et al. 2019

Front. Neurosci.

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“…The success of the procedure was defined as a decrease of 50% or more in the NRS score without increasing analgesic consumption [11,12]. All other responses were deemed negative responses.…”

Section: Methodsmentioning

confidence: 99%

The effect of needle tip position on the analgesic efficacy of pulsed radiofrequency treatment in patients with chronic lumbar radicular pain: a retrospective observational study

Kim

Park

2019

Korean J Pain

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BackgroundPulsed radiofrequency (PRF) is a treatment modality that alleviates radicular pain by intermittently applying high-frequency currents adjacent to the dorsal root ganglion. There has been no comparative study on analgesic effect according to the position of the needle tip in PRF treatment. The objective of this study is to evaluate the clinical outcomes of PRF according to the needle tip position.MethodsPatients were classified into 2 groups (group IP [group inside of pedicle] and group OP [group outside of pedicle]) based on needle tip position in the anteroposterior view of fluoroscopy. In the anteroposterior view, the needle tip was advanced medially further than the lateral aspect of the corresponding pedicle in group IP; however, in group OP, the needle tip was not advanced. The treatment outcomes and pain scores were evaluated at 4, 8, and 12 weeks after applying PRF.ResultsAt 4, 8, and 12 weeks, there were no significant differences between the successful response rate and numerical rating scale score ratio.ConclusionsThe analgesic efficacy of PRF treatment did not differ with the needle tip position.

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“…Similarly an imbalance in NK and T reg cells leading to loss of NK cell function by the release of immuno-suppressive cytokine such as TGF-β may contribute to low back pain (Luchting et al, 2014(Luchting et al, , 2015. On the other hand, treatment of radicular pain patients with pulsed radiofrequency to the DRG, which led to improved pain outcomes, reduced NK cell frequency in cerebrospinal fluid (CSF) (Das et al, 2018), although peripheral blood counts were not reported.…”

Section: Evidence Of Nk Cell Function In Pain Syndromesmentioning

confidence: 99%

Cytotoxic Immunity in Peripheral Nerve Injury and Pain

et al. 2020

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Human dorsal root ganglion pulsed radiofrequency treatment modulates cerebrospinal fluid lymphocytes and neuroinflammatory markers in chronic radicular pain

Cited by 33 publications

References 24 publications

CT-Guided Stellate Ganglion Pulsed Radiofrequency Stimulation for Facial and Upper Limb Postherpetic Neuralgia

CT-Guided Stellate Ganglion Pulsed Radiofrequency Stimulation for Facial and Upper Limb Postherpetic Neuralgia

The effect of needle tip position on the analgesic efficacy of pulsed radiofrequency treatment in patients with chronic lumbar radicular pain: a retrospective observational study

Cytotoxic Immunity in Peripheral Nerve Injury and Pain

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