Human Diversity in Jordan: Polymorphic<i>Alu</i>Insertions in General Jordanian and Bedouin Groups

Zanetti, Daniela; Sadiq, May F.; Carreras‐Torres, Robert; Khabour, Omar F.; Alkaraki, Almuthanna K.; Esteban, Esther; Via, Marc; Moral, Pedro

doi:10.3378/027.086.0201

Cited by 9 publications

(2 citation statements)

References 23 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, in the European and Mediterranean context, these regions of epidemiological importance exhibit the same genetic variation pattern described using sets of neutral markers (e.g. Alu insertion polymorphisms) and genome-wide arrays in previous population studies [ 39 , 40 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 61%

Potential Signals of Natural Selection in the Top Risk Loci for Coronary Artery Disease: 9p21 and 10q11

et al. 2015

Self Cite

View full text Add to dashboard Cite

BackgroundCoronary artery disease (CAD) is a complex disease and the leading cause of death in the world. Populations of different ancestry do not always share the same risk markers. Natural selective processes may be the cause of some of the population differences detected for specific risk mutations.ObjectiveIn this study, 384 single nucleotide polymorphisms (SNPs) located in four genomic regions associated with CAD (1p13, 1q41, 9p21 and 10q11) are analysed in a set of 19 populations from Europe, Middle East and North Africa and also in Asian and African samples from the 1000 Genomes Project. The aim of this survey is to explore for the first time whether the genetic variability in these genomic regions is better explained by demography or by natural selection.ResultsThe results indicate significant differences in the structure of genetic variation and in the LD patterns among populations that probably explain the population disparities found in markers of susceptibility to CAD.ConclusionsThe results are consistent with potential signature of positive selection in the 9p21 region and of balancing selection in the 9p21 and 10q11. Specifically, in Europe three CAD risk markers in the 9p21 region (rs9632884, rs1537371 and rs1333042) show consistent signals of positive selection. The results of this study are consistent with a potential selective role of CAD in the configuration of genetic diversity in current human populations.

show abstract

Section: Discussionmentioning

confidence: 61%

Potential Signals of Natural Selection in the Top Risk Loci for Coronary Artery Disease: 9p21 and 10q11

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…The number of genetic studies from Jordan increased within the last two decades. This could be due to increased research capacity; the prevalence of different genetic diseases, which were reported to be high among Jordanians as a result of consanguinity and high birth rate; [15][16][17] and having a diverse population that contains many ethnic groups and minorities, 18,19 along with the significant jumps in the census due to waves of immigration toward Jordanian territories from surrounding high tension countries. This increase in the number of genetic studies in Jordan should have been accompanied with an increase in awareness of the importance of applying ethical obligations and morals in the research process including proper informed consent process.…”

Section: Discussionmentioning

confidence: 99%

<p>Informed Consent Form Challenges for Genetic Research in Jordan</p>

Alkaraki¹,

Khabour²,

Alzoubi³

et al. 2020

JMDH

View full text Add to dashboard Cite

Background: Informed consent is an obligatory requirement for research engaging human subjects. Informed consent form (ICF) should be provided for human subjects to confirm their willingness for voluntary participation in a study. Ethical and legal obligations necessitate the presence of informed consent essential items to be built into the ICF. Objective: To evaluate the content of ICFs obtained from different genetic studies accomplished in Jordan and their adherence to ethical guidelines proposed by the International Conference on Harmonization-Good Clinical Practice (ICHGCP). Methods and Measures: A total of 44 ICFs obtained from master theses and grant proposals at two major universities in Jordan were analyzed according to the good clinical practice criteria proposed by ICHGCP. ICFs were scored for the presence or absence of ICF main items/categories. Results: Results show inadequate information present in the examined ICFs. The highest information score was 17 out of 20, while the lowest score was one out of 20. The average score for all studied ICFs was 6.18±3.65. Among essential items/categories that were absent from the majority of studied ICFs were a statement about voluntary participation, confidentiality of data, compensation to study participants, risk/benefits of the study, and researchers' contact information. Conclusion: The ICFs were missing a number of required items. This could reflect inadequate knowledge about minimal informed consent requirements among Jordanian investigators highlighting the need for research ethical training in the country.

show abstract

Assessing the forensic efficiency of the GlobalFiler STR loci among the genetically isolated Chechen subpopulation in Jordan

AL-Eitan

Darwish

Hakooz

et al. 2019

Gene

View full text Add to dashboard Cite

Human Diversity in Jordan: PolymorphicAluInsertions in General Jordanian and Bedouin Groups

Abstract: Abstract. Jordan, located in the Levant region, is a crucial area to investigate human migration between Africa and Eurasia. Even thought, the genetic history of and their apparent selective neutrality.

Cited by 9 publications

References 23 publications

Potential Signals of Natural Selection in the Top Risk Loci for Coronary Artery Disease: 9p21 and 10q11

Potential Signals of Natural Selection in the Top Risk Loci for Coronary Artery Disease: 9p21 and 10q11

<p>Informed Consent Form Challenges for Genetic Research in Jordan</p>

Assessing the forensic efficiency of the GlobalFiler STR loci among the genetically isolated Chechen subpopulation in Jordan

Contact Info

Product

Resources

About