Human disease associated with "Campylobacter upsaliensis" (catalase-negative or weakly positive Campylobacter species) in the United States

Patton, C M; Shaffer, Nathan; Edmonds, Paul; Barrett, Timothy J.; Lambert, M A; Baker, C N; Perlman, Daniel; Brenner, Don J.

doi:10.1128/jcm.27.1.66-73.1989

Cited by 106 publications

(43 citation statements)

References 17 publications

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“…C. upsaliensis has also been isolated from the feces of children and adults with diarrhea (25,44,55), as well as from the blood of pediatric patients and adults with septicemia (31,39,44). Other extraintestinal sites from which this organism has been cultured include a breast abscess (23) and the fetoplacental tissue of an 18-week-pregnant woman who had contact with a household cat.…”

Section: Discussionmentioning

confidence: 99%

“…There is other epidemiological evidence that suggests that C. upsaliensis may have zoonotic potential. One study of C. upsaliensis infection reported that four of seven humans infected had animal contact (44). C. upsaliensis was also isolated from a diarrheic patient and his clinically healthy dog (26).…”

Section: Discussionmentioning

confidence: 99%

“…C. upsaliensis, a catalase-negative or weakly positive Campylobacter sp. initially isolated from diarrheic or nondiarrheic domestic dogs and cats (20,48), has also been associated with enteritis (25,44,55) and bacteremia (31,39,44) in humans. More-serious illnesses, including spontaneous abortion and hemolytic-uremic syndrome, have also been reported for a human infected with C. upsaliensis (27).…”

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confidence: 99%

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Coinfection of Enteric Helicobacter spp. and Campylobacter spp. in Cats

et al. 2001

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During a 6-year period, 64 of 227 commercially reared cats had microaerobic bacteria isolated from their feces. All the isolates were initially identified as Campylobacter-like organisms based on biochemical and phenotypic characteristics. DNA extractions from 51 of these isolates were subjected to PCR using primers specific for Helicobacter spp. and Campylobacter spp. Of the isolates, 92% (47 of 51 isolates) were positive for Campylobacter spp., 41% (21 of 51 isolates) were positive for Helicobacter spp., 33% (17 of 51 isolates) were positive for both genera, 59% (30 of 51 isolates) were positive only for Campylobacter spp., and 8% (4 of 51) were positive only for Helicobacter spp. Sixteen of the 47 Campylobacter-positive cultures were positive for more than one Campylobacter spp. Based on a species-specific PCR assay, 83% of the isolates were identified as Campylobacter helveticus, 47% of the isolates were identified as Campylobacter upsaliensis, and 6% of the isolates were classified as Campylobacter jejuni. The 1.2-kb PCR products of the 16S rRNA genes of 19 Helicobacter species isolates were subjected to restriction fragment length polymorphism (RFLP) analysis. Of the five different RFLP patterns obtained, two clustered with Helicobacter ("Flexispira") taxon 8, one clustered with Helicobacter bilis, one clustered with Helicobacter canis, and the remaining pattern was closely related to a novel Helicobacter sp. strain isolated from a woodchuck. The sequence data for the 16S rRNA genes of 10 Helicobacter spp. validated the RFLP-based identification of these isolates. This study demonstrated that biochemical and phenotypic characteristics of microaerobic organisms in cat feces were insufficient to characterize mixed Helicobacter and Campylobacter infections. Molecular structure-based diagnostics using genus-and speciesspecific PCR, RFLP analysis, and 16S rRNA sequence analysis enabled the identification of multiple microaerobic species in individual animals. The clinical relevance of enteric Helicobacter and Campylobacter coinfection in cats will require further studies.Cats are recognized reservoirs for enteric Campylobacter spp., including Campylobacter jejuni, Campylobacter coli, Campylobacter upsaliensis, and Campylobacter helveticus (5,13,20,37,58). C. jejuni and C. coli are among the most frequently encountered human enteric pathogens worldwide (2, 3). C. upsaliensis, a catalase-negative or weakly positive Campylobacter sp. initially isolated from diarrheic or nondiarrheic domestic dogs and cats (20,48), has also been associated with enteritis (25, 44, 55) and bacteremia (31, 39, 44) in humans. More-serious illnesses, including spontaneous abortion and hemolytic-uremic syndrome, have also been reported for a human infected with C. upsaliensis (27). Campylobacter infections, particularly C. jejuni infections, are zoonotic and are a particular problem among puppies and kittens from shelters (13, 18, 45). C. helveticus, which is closely related to C. upsaliensis, has also been isolated from domestic cats an...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Coinfection of Enteric Helicobacter spp. and Campylobacter spp. in Cats

et al. 2001

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“…In the immunocompetent host, this thermophilic campylobacter is most commonly associated with acute self-limited diarrhea [4,5]. However, C. upsaliensis has been associated with chronic diarrhea and failure to thrive in children [6] and can cause bacteremia in immunocompromised patients [3,7].…”

Section: Lntrnductionmentioning

confidence: 99%

Pulsed-field gel electrophoresis indicates genotypic heterogeneity among Campylobacter upsaliensis strains

Bourke¹,

Sherman²,

Woodward³

et al. 1996

FEMS Microbiology Letters

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To determine the genomic relatedness among a selection of animal and human Campylobacter upsaliensis isolates, macrorestriction profiles were generated for 20 C. upsaliensis strains, among 7 serogroups, using pulsed-field gel electrophoresis (PFGE). XhoI, SalI and SacII restriction enzyme profiles indicated genomic heterogeneity among strains. Using XhoI and SacII restriction enzyme digestion, genomic similarities between some pairs of strains were Lior serogroup specific. The genomic sizes of these isolates varied from 1.74 to 2.09 Mb. These results demonstrate molecular heterogeneity of this species similar to that found among Helicobacter pylori isolates. Among C. upsaliensis strains, PFGE is highly discriminatory and should prove a useful molecular typing method for epidemiological purposes.

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“…were isolated from both diarrhoeic and asymptomatic dogs using a passing filtration technique (Sandstedt et al 1983). Since then other reports have described the isolation of these organisms and have suggested they are potential human pathogens associated with enteritis and bacteraemia, and also opportunist infections in immunocompromised individuals (Steele et al 1985 ;Lastovica et al 1989;Patton et al 1989;Taylor et al 1989;Chusid et al 1990;Goossens et al 1990). In 1991 DNA hybridization studies showed that this group of organisms belonged to a new species and the name Campylobacter upsalienszs was proposed (Sandstedt and Ursing 1991).…”

Section: Introductionmentioning

confidence: 99%

A comparison of a new campylobacter selective medium (CAT) with membrane filtration for the isolation of thermophilic campylobacters including Campylobacter upsaliensis

Aspinall

Wareing

Hayward

et al. 1996

Journal of Applied Bacteriology

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The newly developed CAT campylobacter selective medium employing the blood-free charcoal-based agar containing cefoperazone (8 mg l-1), amphotericin (10 mg l-1) and teicoplanin (4 mg l-1) was compared with the membrane filtration culture technique for isolation of Campylobacter spp. including Camp. upsaliensis. Nine hundred and fifty human, 275 dog and 65 cat faeces (in which modified CCDA medium was also compared) were tested. In addition, the recovery of Camp. upsaliensis from pure cultures and from spiked human faeces was examined after membrane filtration. A 50-fold reduction in recovery after filtration using the 0.65 micron filters and a 150-fold reduction using the 0.45 micron filters was found. Recovery of Camp. upsaliensis from spiked faeces was considerably improved using the CAT medium compared with filtration, especially with the lower concentration of organisms (approx. 10(4) cfu mL-1). Campylobacter upsaliensis was recovered from 91 specimens of animal faeces, with CCDA recovering 26 isolates (29%), CAT recovering 76 isolates (84%) and membrane filtration (0.65 microns) recovering 82 isolates (90%). CAT selective agar was found to be a suitable medium for the isolation of thermophilic campylobacters including Camp. upsaliensis from faecal samples.

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Human disease associated with "Campylobacter upsaliensis" (catalase-negative or weakly positive Campylobacter species) in the United States

Cited by 106 publications

References 17 publications

Coinfection of Enteric Helicobacter spp. and Campylobacter spp. in Cats

Coinfection of Enteric Helicobacter spp. and Campylobacter spp. in Cats

Pulsed-field gel electrophoresis indicates genotypic heterogeneity among Campylobacter upsaliensis strains

A comparison of a new campylobacter selective medium (CAT) with membrane filtration for the isolation of thermophilic campylobacters including Campylobacter upsaliensis

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