Human dirofilariosis of buccal mucosa – First molecularly confirmed case and literature review

Momčilović, Stefan; Gabrielli, Simona; Golubović, Milan; Smilić, Tanja; Krstić, Miljan; Đenić, Saša; Ranđelović, Marina; Otašević, Suzana

doi:10.1016/j.parint.2019.101960

Cited by 8 publications

(5 citation statements)

References 49 publications

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“…Описаны аутохтонные случаи дирофиляриатоза легких с развитием плеврита и опухолевидных образований в легких [17]. Как правило, D. repens мигрируют под кожу век, головы, шеи, туловища, верхних и нижних конечностей, реже -в молочные железы, а также в слизистые [18]. Описаны случаи локализации гельминта в ротовой полости.…”

Section: Discussionunclassified

“…Хотя человек является тупиковым хозяином, полностью исключить микрофиляриемию нельзя. Часть самок достигает половозрелости, и в научной литературе уже описано несколько случаев микрофиляриемии [1,2,[16][17][18]. Именно поэтому необходимо полноценное морфологическое и паразитологическое исследование удаленного гельминта, в случае обнаружения микрофилярий в матке оплодотворенной самки целесообразно проведение многократного обследования пациента с применением методов обогащения для исследования венозной крови.…”

Section: Discussionunclassified

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Human dirofilariasis: a rare disease or a problem of our time?

Bakovetskaya,

Zhiltsova,

Terehina

et al. 2024

Medicinskij sovet

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The article presents the current state of the problem of dirofilariasis. Helminth infection caused by nematodes of the genus Dirofilaria is mainly a disease of carnivores from the canine and feline families. Humans are considered occasional hosts in which Dirofilaria spp., more commonly D. repens, rarely reach sexual maturity. The climatic conditions of the territory are one of the determining factors for the spread of vector-borne diseases. Due to the fact that in recent years there has been a tendency to increase average temperatures everywhere, these changes lead to a shift and expansion of the ranges of many organisms, including pathogens and vectors of various diseases. The clinical picture of human dirofilariasis caused by D. repens most often manifests itself in one of two clinical forms -subcutaneous and ocular, although, according to the literature, there are cases of damage to other localizations. Due to the fact that damage to the organs of vision occurs most often in humans, the clinical case presented by us is relevant. The patient, in our clinical case, permanently lived in one of the districts of the Ryazan region. The landscape and natural complex of this region, taking into account the presence of a large number of wetlands, an abundance of water bodies and suitable climatic conditions, creates a favorable environment for the development of insects of the Culicidae family (mosquitoes of the genera Anopheles, Culex, etc.), which are transmissible carriers of various human and animal diseases, including dirofilariasis. The complex cycle of the parasite, the possibility of migration in the body can lead to multiple organ damage. Scientific publications describe cases of finding dirofilaria in the lungs, heart, and genitourinary system. In this regard, the awareness of doctors and patients about this disease is very relevant, and will reduce the likelihood of prolonging the correct diagnosis and treatment.

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Section: Discussionunclassified

Human dirofilariasis: a rare disease or a problem of our time?

Bakovetskaya,

Zhiltsova,

Terehina

et al. 2024

Medicinskij sovet

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“…5,6,13, 14 In 2019, the first case of dirofilariasis affecting the oral mucosa was described in Serbia. 15 The increasing number of dirofilariasis cases in Europe is associated with significant climate change (global warming), the growth of mosquito populations (intermediate host / vector), as well as the global migration of people and animals (especially dogs), all of which are considered the most important factors in the expansion of the disease. 4,8…”

Section: Discussionmentioning

confidence: 99%

Multiple subcutaneous <i>Dirofilaria repens</i> infection in a patient from Poland with a rheumatic history

Czyżewska,

Zajkowska,

Sałamatin

et al. 2023

Polish Archives of Internal Medicine

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site subcutaneous Dirofilaria repens infection 1 occurs in 2 clinical forms: as subcutaneous / submucosal nodules or as interstitial lung disease. In many cases, the disease proceeds asymptomatically or with nonspecific symptoms, which can delay the correct diagnosis. Involvement of the eyeball is possible, and the parasite is then visible under the conjunctiva. A common manifestation of the disease is also a breast lump, which may be misdiagnosed as a neoplastic process. The biggest challenge associated with diagnosing dirofilariasis is its initial misdiagnosis as a primary tumor or lung metastases. Serological blood tests, the Knott's test, imaging examinations (chest X -ray, ultrasound examination, computed tomography, magnetic resonance imaging), as well as biopsy and histopathologic examination may be helpful in diagnosing dirofilariasis. Molecular biology methods are also used increasingly often to confirm the disease. 6 Patient and methods Patient A 47 -year -old woman with a history of hypothyroidism and degenerative joint disease was admitted to the Department of Infectious Disease and Neuroinfection at the University Clinical Hospital in Białystok on December 20, 2019, with migratory skin pain and nonspecific subcutaneous nodules. Initially, in March 2019, and subsequently in October 2019, the patient had the subcutaneous nodules removed from the right upper limb. After the procedure, the patient underwent diagnostic workup for rheumatologic, hematologic, and dermatologic disorders. One of the extracted nodule was subjected to a histopathologic examination on October 31, 2019, which revealed a necrotic focus with a cluster of parasitic nematode larvae. The histopathologic material was sent to

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“…Our search showed six cases of human oral Dirofilaria repens from the European part of the world. Two of them were from France [ 9 , 23 ], and one each was from Italy [ 13 ], Russia [ 18 ], Serbia [ 22 ], and Bulgaria [ 24 ]. Most of the reported cases were from Sri Lanka (nine cases) [ 11 , 17 ] and the rest were from India (five cases) [ 1 , 10 , 12 , 15 , 16 ], Brazil (two cases) [ 19 , 20 ], the United States (one case) [ 21 ], and China (one case) [ 14 ], confirming tropical parts of Asia as endemic areas of Dirofilaria repens infestation.…”

Section: Discussionmentioning

confidence: 99%

Live Intraoral Dirofilaria repens of Lower Lip Mimicking Mucocele—First Reported Case from Croatia

Škrinjar

Brailo

Brzak

et al. 2022

IJERPH

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Dirofilariasis is an endemic infestation in tropical and subtropical countries caused by about 40 different species. It rarely occurs in the oral cavity and is mostly presented as mucosal and submucosal nodules. Differential diagnoses include lipoma, mucocele, and pleomorphic adenoma. We report a rare case of oral dirofilariasis mimicking mucocele in a 41-year-old male patient from Croatia without an epidemiological history of travelling outside the country. He came in because of non-painful lower lip swelling that had lasted for two months. The parasite was surgically removed from the lesion. This is the first reported case of oral dirofilariasis in Croatia. It is important to point out this rare diagnosis in order to make dentists aware of the possibility of the presence of such an infestation in common lesions of the oral mucosa.

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Human dirofilariosis of buccal mucosa – First molecularly confirmed case and literature review

Cited by 8 publications

References 49 publications

Human dirofilariasis: a rare disease or a problem of our time?

Human dirofilariasis: a rare disease or a problem of our time?

Multiple subcutaneous <i>Dirofilaria repens</i> infection in a patient from Poland with a rheumatic history

Live Intraoral Dirofilaria repens of Lower Lip Mimicking Mucocele—First Reported Case from Croatia

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