Human dietary exposure to perfluoroalkyl substances in Catalonia, Spain. Temporal trend

Domingo, José L.; Jogsten, Ingrid Ericson; Eriksson, Ulrika; Martorell, Isabel; Perelló, Gemma; Nadal, Martí; Bavel, Bert van

doi:10.1016/j.foodchem.2012.06.054

Cited by 111 publications

(62 citation statements)

References 40 publications

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“…Even fewer are the studies focusing on fish and shellfish from the Mediterranean Sea. More specifically, there are studies reporting PFC levels in shellfish from France (Munschy et al, 2013), Spain (Domingo et al, 2012b) and Italy (Nania et al, 2009 andGuerranti et al, 2013), farmed fish from Italy (Paiano et al, 2013) and marine fish from Spain (Domingo et al, 2012b) and Italy (Nania et al, 2009). The results reported from Italy by Nania et al, refer to different species of Mediterranean fish and shellfish, with the exception of Loligo vulgaris (common squid) and species of mussel and red mullet which are relatives of the species studied herein.…”

Section: Resultsmentioning

confidence: 73%

Levels of perfluorinated compounds in raw and cooked Mediterranean finfish and shellfish

et al. 2015

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Section: Resultsmentioning

confidence: 73%

Levels of perfluorinated compounds in raw and cooked Mediterranean finfish and shellfish

et al. 2015

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“…In Sweden, estimated dietary exposure to PFUA increased (88, 158 and 212 pg/kg/day in 1999, 2005 and 2010, respectively) along with an increase in the quantified concentration of PFUA in fish products (Vestergren et al, 2012). Domingo et al (2012) summarized that the major dietary source of the estimated intake of PFUA was fish and shellfish.…”

Section: Introductionmentioning

confidence: 99%

Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid in rats

Takahashi¹,

Ishida

Hirata-Koizumi³

et al. 2014

J. Toxicol. Sci.

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-Perfluoroalkyl acids (PFAAs) are environmental contaminants that have received attention because of their possible effects on wildlife and human health. In order to obtain initial risk information on the toxicity of perfluoroundecanoic acid (PFUA), we conducted a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD test guideline 422). PFUA was administered by gavage to rats at 0 (vehicle: corn oil), 0.1, 0.3 or 1.0 mg/kg/day. At 1.0 mg/kg/day, body weight gain was inhibited in both sexes, and there was a decrease in fibrinogen in both sexes and shortening of the activated partial thromboplastin time in males. An increase in blood urea nitrogen and a decrease in total protein in both sexes and increases in alkaline phosphatase and alanine transaminase and a decrease in albumin in males were observed at 1.0 mg/kg/day. Liver weight was increased in males at 0.3 mg/kg/day and above and in females at 1.0 mg/kg/day, and this change was observed after a recovery period. In both sexes, centrilobular hypertrophy of hepatocytes was observed at 0.3 mg/kg/day and above and focal necrosis was observed at 1.0 mg/kg/day. In reproductive/developmental toxicity, body weight of pups at birth was lowered and body weight gain at 4 days after birth was inhibited at 1.0 mg/kg/day, while no dose-related changes were found in the other parameters. Based on these findings, the no observed adverse effect levels (NOAELs) for the repeated dose and reproductive/developmental toxicity were considered to be 0.1 mg/kg/day and 0.3 mg/kg/day, respectively.

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“…Water intake was assumed to be 1.0 L d ¡1 (Nissensohn, Castro-Quezada, and Serra-Majem 2013), the mean body weight was set at 70 kg. The daily intake of PFASs through food and water for the population of Tarragona County (Table 1) was obtained from Ericson et al (2009) and Domingo et al (2012). A constant intake was considered for the lifespan of the individuals under study.…”

Section: Toxicological and Environmental Chemistrymentioning

confidence: 99%

Physiologically based pharmacokinetic modeling of perfluoroalkyl substances in the human body

Fàbrega

Kumar

Benfenati

et al. 2015

Toxicological & Environmental Chemistry

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Human dietary exposure to perfluoroalkyl substances in Catalonia, Spain. Temporal trend

Cited by 111 publications

References 40 publications

Levels of perfluorinated compounds in raw and cooked Mediterranean finfish and shellfish

Levels of perfluorinated compounds in raw and cooked Mediterranean finfish and shellfish

Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid in rats

Physiologically based pharmacokinetic modeling of perfluoroalkyl substances in the human body

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