2011
DOI: 10.1007/s00418-011-0858-3
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Human dental pulp stem cells demonstrate better neural and epithelial stem cell properties than bone marrow-derived mesenchymal stem cells

Abstract: Dental pulp stem cells (hDP-SCs) were primarily derived from pulp tissues of primary incisors, exfoliated deciduous and permanent third molar teeth. To understand the characteristics of hDP-SCs from impacted third molar, proliferation capacities, gene expression profiles, phenotypic, ultrastructural, and differentiation characteristics were analyzed in comparison with human bone marrow-derived mesenchymal stem cells (hBM-MSCs), extensively. hDP-SCs showed more developed and metabolically active cells. Contrary… Show more

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Cited by 177 publications
(130 citation statements)
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“…This finding was comparable with results from pioneer study performed by Johnstone et al (1999) who reported chondrogenic potential of mesenchymal stem cells derived from bone marrow cultured as aggregate. Similar results were obtained by other authors with ATSCs and other stem cells (Zuk et al 2002;Karaöz et al 2011;Lovati et al 2011). So it is very important to mimic 3D structure which occurred in hyaline cartilage in vivo to promote chondrogenesis in vitro.…”
Section: Discussionsupporting
confidence: 81%
“…This finding was comparable with results from pioneer study performed by Johnstone et al (1999) who reported chondrogenic potential of mesenchymal stem cells derived from bone marrow cultured as aggregate. Similar results were obtained by other authors with ATSCs and other stem cells (Zuk et al 2002;Karaöz et al 2011;Lovati et al 2011). So it is very important to mimic 3D structure which occurred in hyaline cartilage in vivo to promote chondrogenesis in vitro.…”
Section: Discussionsupporting
confidence: 81%
“…A study by Karaöz et al has also proposed a more efficient differentiation of dental pulp-derived stem cells into neuronal and epithelial lineage compared with bone marrow-derived stem cells. It has been also shown that these stem cells derived from the two origins (dental pulp and bone marrow) show dissimilar gene expression profile, proliferation ability, phenotypic features, ultrastructural, and differentiation properties (Karaöz et al, 2011). Another controversial study, conducted by De Miguel et al, supposed a different capacity of MSCs originated from various tissues regarding their immunomodulatory effects upon the transplantation.…”
Section: Introductionmentioning
confidence: 99%
“…As stem cell origin directly determines the transformation capacity into targeted cell lineage, selection of stem cells source for a specific regeneration case is vital for the functionality and effectivity of the treatment. For instance, dental pulp stem cells (DPSCs) have been proven to display better neural and epithelial differentiation potential in comparison with BMCSs (Karaöz et al 2011), indicating higher potential of DPSCs in neuroregeneration. Apart from cell source, using differentiation regulators is also important to control differentiation procedure and increase the treatment efficiency.…”
Section: Discussionmentioning
confidence: 99%