“…SHED express embryonic stem cell markers Oct-4 and Nanog, the mesenchymal stem cell marker stromal precursor antigen-1 (STRO-1), and the neuronal stem cell marker Nestin and possess high prolifer-ation capacity; SHED also show multidifferentiation potential and can differentiate into neuronal, osteogenic, adipogenic, and hepatogenic cells (Ma et al, 2012;Miura et al, 2003;Yamaza et al, 2015). SHED have been shown to be able to differentiate into neurons, astrocytes, and oligodendrocytes (Jarmalavičiūtė et al, 2013;Miura et al, 2003;Nourbakhsh et al, 2011;Sakai et al, 2012). The dopaminergic differentiation of SHED has been reported previously, and the engraftment of dopaminergic neurons obtained from SHED in the brain has been shown to improve the production of dopamine and the abnormal behaviors of Parkinsonian rats (Fujii et al, 2015;Wang et al, 2010).…”