Human Cytomegalovirus Seropositivity Is Associated With Impaired Vascular Function

Abstract

Background-Herpesvirus infection is a possible risk factor for atherogenesis, and diabetics may be at particular risk.Endothelial dysfunction is an early marker for atherosclerosis, and the present study tests the hypotheses that (1) prior infection with cytomegalovirus (CMV) and herpes simplex virus (HSV) is associated with endothelial dysfunction and (2) this may be more marked in diabetics. Methods and Results-Serum samples were tested for anti-IgG antibodies to CMV and HSV from 400 subjects (mean age for diabetics and nondiabetics, 37.8Ϯ4.3 and 37.9Ϯ3.7 [SD]). We also assessed Helicobacter pylori and Chlamydia pneumoniae serology. Coronary atheroma was quantified by means of electron beam computed tomography. Subjects (nϭ157) underwent venous occlusion plethysmography with acetylcholine, bradykinin, glyceryl trinitrate, norepinephrine, and L-N G -monomethyl-L-arginine. Individuals who were seropositive for CMV had reduced responses to bradykinin (Pϭ0.005) and glyceryl trinitrate (Pϭ0.006). The reduced response to bradykinin remained significant (Pϭ0.045) after adjusting for the response to glyceryl trinitrate and was independent of conventional risk factors. Positive serology for the other organisms did not have an independent effect on reactivity. There was a weaker association between CMV and coronary artery calcification (Pϭ0.09). Positive serology for each of the other pathogens did not affect reactivity, but there was a relation between total pathogen burden and impaired vascular reactivity. No significant differences were found between diabetics and nondiabetics. Conclusions-This

Breakthrough Treatment of Hypertension, Hypertension’s “Syndrome X” is now Re-defined.

“…As the documentation of Enhanced cytomegalovirus infection in atherosclerotic human blood vessels, causing hypertension has been concluded. 35 And the Detection of human cytomegalovirus DNA, RNA, and antibodies in normal donor blood. 35 Antiviral infusions with the neuronal complimentary drugs were administered twice a day for 10 days.…”

“…35 And the Detection of human cytomegalovirus DNA, RNA, and antibodies in normal donor blood. 35 Antiviral infusions with the neuronal complimentary drugs were administered twice a day for 10 days. Vitals were recorded every 4 hours.…”

“…Great many possible parameters have been established to view the existence of the hypertension, Bacterial, Viral 35 , Hormonal and anatomical 3 . In the recent years, scientists are looking closely at the Neuroinvasive viruses and their role in the cardiovascular disease.…”

“…In the recent years, scientists are looking closely at the Neuroinvasive viruses and their role in the cardiovascular disease. 3,[22][23][24][25][26][27][28][29][30][31][32][33][34][35] Most scientists agree to a common instigator of the cardiac pathology that anatomically leads to hypertension. 3 The pathological issues can only be resolved by the medical intervention.…”

Cytomegalovirus Infection and Coronary Artery Disease: A Single-Center Serological Study in Northwestern Iran

“…Ji et al conducted an aggregate data metaanalysis involving 9,000 patients with CAD and 8,608 controls from a total of 55 studies, and concluded that CMV infection was associated with an increased risk of CAD (24). In this regard, some suggested potential mechanisms include vessel wall colonization, enhancement of body's pre-existing inflammatory response to risk factors such as hyperlipidemia, destabilization of the pre-existing plaques by activating the immune response, endothelial dysfunction, or even cross-reaction of the anti-CMV antibodies with heat shock proteins during the CMV infection and the subsequent apoptosis of the non-stressed endothelial cells (16,(25)(26)(27)(28)). Yet, the most accepted mechanism through which CMV may contribute to atherogenesis is provocation of inflammatory response in the host (29).…”