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2008
DOI: 10.1128/jvi.00502-08
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Human Cytomegalovirus Secretome Contains Factors That Induce Angiogenesis and Wound Healing

Abstract: Human cytomegalovirus (HCMV) is implicated in the acceleration of a number of vascular diseases including transplant vascular sclerosis (TVS), the lesion associated with chronic rejection (CR) of solid organ transplants. Although the virus persists in the allograft throughout the course of disease, few cells are directly infected by CMV. This observation is in contrast to the global effects that CMV has on the acceleration of TVS/CR, suggesting that CMV infection indirectly promotes the vascular disease proces… Show more

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Cited by 102 publications
(113 citation statements)
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References 43 publications
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“…Consequently, IE84-mediated inhibition of p53 function may enhance proliferation of SMCs and contribute to coronary restenosis (129). HCMV-infected fibroblasts and ECs secrete PDGF, a mitogen and chemoattractant for mesenchymal cells, and TGF-b, which may produce changes in myofibroblasts and pericytes to promote stabilization of new vessels (120,133). Because SMC migration into the neointimal space is the hallmark of vascular disease, these observations provide a molecular link between HCMV and graft arterial vascular disease (134).…”
Section: Colony-stimulating Factor) Hcmv Infection Of Ecs Induces Exmentioning
confidence: 99%
See 1 more Smart Citation
“…Consequently, IE84-mediated inhibition of p53 function may enhance proliferation of SMCs and contribute to coronary restenosis (129). HCMV-infected fibroblasts and ECs secrete PDGF, a mitogen and chemoattractant for mesenchymal cells, and TGF-b, which may produce changes in myofibroblasts and pericytes to promote stabilization of new vessels (120,133). Because SMC migration into the neointimal space is the hallmark of vascular disease, these observations provide a molecular link between HCMV and graft arterial vascular disease (134).…”
Section: Colony-stimulating Factor) Hcmv Infection Of Ecs Induces Exmentioning
confidence: 99%
“…This includes laminins and >41 cytokines, chemokines and chemokine receptors that affect angiogenesis and wound healing (chemokines IL-6, osteoprotegerin, growth-regulated oncogene, C-C motif chemokine ligand [CCL] 3, CCL5, CCL7, CCL20, CXCL5, and CXCL16; receptors TNF receptors I and II and ICAM1; growth factors TGF-b1, hepatocyte growth factor and granulocyte macrophage (122) and VCAM1, which, in the early phase of infection, enhance transendothelial cell migration of inflammatory cells including monocytes, promoting angiogenesis by secretion of VEGF (120,123). Vascular proliferation is facilitated by degradation of basal membranes by matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase released by HCMV-infected fibroblast and epithelial cells (120).…”
Section: Proangiogenic and Proliferative Effectsmentioning
confidence: 99%
“…69,71,72 Manipulation of the cellular microenvironment by changes in the cell secretome HCMV lytic infection is also known to induce profound alterations in levels of secreted cellular proteins (secretome) and this includes a number of chemokines and cytokines with immune functions. 73,74 However, until recently, little was known about latency-associated changes in the cell secretome. The possibility that viral manipulation of secreted cellular proteins would likely be an effective mechanism to modify the microenvironment around latently infected cells to help maintain life-long carriage of latent virus in the face of constant immune surveillance has been investigated by us and others.…”
Section: Immune Evasion Strategies During Latent Infectionmentioning
confidence: 99%
“…HCMV is known to regulate the secretion of numerous cellular chemokines, cytokines, and growth factors during lytic infection (7,8). Little is known, however, about the changes that occur in the secretome during latent infection, and yet this is likely to be of great importance for carriage of latently infected cells in vivo.…”
mentioning
confidence: 99%