Human cytomegalovirus (CMV)-specific CD8+ T cell responses are reduced in HIV-infected individuals with a history of CMV disease despite CD4+ T cell recovery

Singh, Kasha; Howard, Jonathan; Wild, Stefan; Jones, S L; Hoy, Jennifer; Lewin, Sharon R.

doi:10.1016/j.clim.2007.04.018

Cited by 13 publications

(11 citation statements)

References 26 publications

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“…The Quanti-FERON-CMV assay has been shown to be of equivalent sensitivity to and, in some cases, more sensitive than the ELISPOT assay and a sensitive and specific test for the detection of virus-specific T-cell responses in both HCMV-seropositive healthy individuals and SOT patients. This assay has also been shown to detect reduced HCMV-specific CD8 ϩ T-cell responses in HIV-infected individuals with a history of HCMV disease (243), and in a proportion of lung transplant patients who developed significant HCMV reactivation in the lung allograft, the QuantiFERON-CMV assay was able to detect a decrease in HCMV immunity in the peripheral blood prior to the episode of HCMV recrudescence in the lung (279). Therefore, this assay may prove to be useful for predicting the likelihood of HCMV disease in immunocompromised HIV-infected and transplant patients and may assist in clinical decisions related to anti-HCMV prophylaxis or therapy.…”

Section: Virus-specific T Cells For Monitoring Of Hcmv Infectionmentioning

confidence: 99%

Immunobiology of Human Cytomegalovirus: from Bench to Bedside

2009

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SUMMARY Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency and periodically reactivates without causing symptoms in healthy individuals. In the absence of an adequate host-derived immune response, this fine balance of permitting viral reactivation without causing pathogenesis is disrupted, and HCMV can subsequently cause invasive disease and an array of damaging indirect immunological effects. Over the last decade, our knowledge of the immune response to HCMV infection in healthy virus carriers and diseased individuals has allowed us to translate these findings to develop better diagnostic tools and therapeutic strategies. The application of these emerging technologies in the clinical setting is likely to provide opportunities for better management of patients with HCMV-associated diseases.

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Section: Virus-specific T Cells For Monitoring Of Hcmv Infectionmentioning

confidence: 99%

Immunobiology of Human Cytomegalovirus: from Bench to Bedside

2009

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“…However, the main reason for upper gastrointestinal complaints in HIV infected individuals is known to be oesophageal candidiasis , which is consistent with our findings of a significant correlation between oral thrush and odynophagia. There are only three other studies using QF‐CMV assay on HIV infected individuals , none of which report on clinical symptoms, hence we could not compare these results with other studies.…”

Section: Discussionmentioning

confidence: 94%

Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea‐Bissau: a cross‐sectional study

Grønborg

Jespersen

Egedal

et al. 2018

Tropical Med Int Health

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“…Early testing of QuantiFERON‐CMV assay has shown that this technology is highly specific and in some cases more sensitive than the ELISPOT assay (Mabtech AB, Nacka Strand, Sweden). Clinical testing of this assays has been successfully carried out in HIV‐infected individuals with a history of HCMV disease 68 and in lung transplant patients who developed significant HCMV reactivation in the lung allograft. In both of these settings, the QuantiFERON‐CMV assay was able to detect a decrease in HCMV immunity in the peripheral blood before the episode of HCMV recrudescence 69 .…”

Section: Clinical Applications Of Herpesvirus‐specific T‐cell Immunitymentioning

confidence: 99%

Understanding human T‐cell‐mediated immunoregulation through herpesviruses

2011

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Human herpesviruses have coevolved with humans over millions of years, and adaptation of latent infection within the cells of the immune system is a unique characteristic of many of these viruses. Following primary infection, these herpesviruses establish an asymptomatic-persistent infection in healthy individuals that is strictly controlled by virus-specific CD8 + and CD4 + T cells. Here, we provide a brief overview of how the human immune system interacts with these latent viruses and regulates the lifelong host-virus relationship in healthy virus carriers. Extensive studies on T-cell-mediated immune regulation over the last decade has allowed researchers to successfully translate these findings into the clinical setting to treat various herpesvirusassociated diseases in transplant patients and individuals with virus-associated malignancies. It is highly likely that these newly emerging T-cell-based therapeutic and diagnostic technologies will revolutionize the clinical management of patients with herpesvirus-associated diseases.

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Human cytomegalovirus (CMV)-specific CD8+ T cell responses are reduced in HIV-infected individuals with a history of CMV disease despite CD4+ T cell recovery

Cited by 13 publications

References 26 publications

Immunobiology of Human Cytomegalovirus: from Bench to Bedside

Immunobiology of Human Cytomegalovirus: from Bench to Bedside

Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea‐Bissau: a cross‐sectional study

Understanding human T‐cell‐mediated immunoregulation through herpesviruses

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