Human cytomegalovirus and Epstein-Barr virus infections, risk factors, and their influence on the liver function of patients with acute-on-chronic liver failure

Hu, Jianhua; Lou, Danfeng; Gao, Hainv; Yang, Meifang; Zhang, Xuan; Jia, Hongyu; Li, Lanjuan

doi:10.1186/s12879-018-3488-8

Cited by 21 publications

(14 citation statements)

References 27 publications

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“…La infección primaria por este virus suele ser adquirida durante la infancia; posteriormente establece un periodo de persistencia a través de las células mieloides o granulocíticos. (5,6) La reactivación o reinfección por virus exógenos es posible y causa alta mortalidad en pacientes inmunocomprometidos, como los que padecen algún tipo inmunodeficiencias o pacientes transplantados. (5,7) El VEB es un virus herpes de clase γ.…”

Section: Discussionunclassified

“…(5,6) La reactivación o reinfección por virus exógenos es posible y causa alta mortalidad en pacientes inmunocomprometidos, como los que padecen algún tipo inmunodeficiencias o pacientes transplantados. (5,7) El VEB es un virus herpes de clase γ. La infección primaria suele manifestarse con un cuadro de mononucleosis infecciosa, caracterizado por fiebre, faringitis y linfadenopatía cervical con o sin hepatoesplenomegalia.…”

Section: Discussionunclassified

“…El VEB desarrolla persistencia en los linfocitos B. (5) Ambos virus son causa común del síndrome mononucleosido, y se estima que su prevalencia en adultos es mayor al 90%. (8) La reactivación de estos virus es posible, sobre todo en pacientes con alguna inmunodepresión.…”

Section: Discussionunclassified

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Hepatitis Aguda Grave por Coinfeccion por Virus Epstein-barr y Citomegalovirus- reporte de caso y revisión de la literatura

Román

Portocarrero

Ancassi

et al. 2020

RFMH

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Section: Discussionunclassified

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Hepatitis Aguda Grave por Coinfeccion por Virus Epstein-barr y Citomegalovirus- reporte de caso y revisión de la literatura

Román

Portocarrero

Ancassi

et al. 2020

RFMH

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“…According to the manufacturer’s instructions, EBV DNA was extracted from blood samples using DNA extraction kit (Daan Gene Co.Ltd., Zhongshan University, China). Quantitative polymerase chain reaction (PCR) was detected on a real-time PCR system (Stratagene MX3000P; Agilent Technologies, Santa Clara, CA, USA), just as our previous reported [30].…”

Section: Methodsmentioning

confidence: 99%

Epstein-Barr virus infection is associated with a higher Child-Pugh score and may predict poor prognoses for patients with liver cirrhosis

Zhang

et al. 2019

BMC Gastroenterol

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Background Studies on Epstein-Barr virus (EBV) have focused mostly on neoplastic disease. Few studies have considered immunocompetent patients who are not severely immunocompromised. Liver cirrhosis is associated with various levels of immune dysfunction. In the current study, we determined EBV infection rates, the influence on liver function, and analyzed the risk factors for death in patients with liver cirrhosis. Methods The medical records of patients diagnosed with liver cirrhosis between 1 January 2014 and 31 December 2016 were reviewed. Patients who were or were not infected with EBV were enrolled in this study. Liver functions were compared. The risk factors for 28-, 90-, and 180-day mortality rates were analyzed by univariate and multivariate logistic regression. Results The medical records hospitalized patients diagnosed with liver cirrhosis were reviewed. Of these patients, 97 had assessed EBV deoxyribonucleic acid (DNA) and 36 (37.1%) patients were EBV DNA-positive. The age of the EBV-infected patients was older than patients not infected with EBV. EBV-infected patients had a lower level of albumin, and a lower albumin-to-globulin ratio ( P = 0.019 and P = 0.013, respectively). EBV-infected patients had higher Child-Pugh scores ( P = 0.033) and higher acute-on-chronic liver failure (ACLF) rate ( P = 0.050). The Child-Pugh score and ACLF were the risk factors for the 28-, 90-, and 180-day mortality rates. Conclusions This study revealed that patients with liver cirrhosis had higher EBV infection rates, especially patients > 60 years of age, which likely reflected viral reactivation. And liver injury was aggravated in EBV-infected patients. Thus, EBV infection indirectly influenced the prognosis of EBV-infected patients by increasing the Child-Pugh score and ACLF rate.

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“…While numerous studies have reported CMV in patients undergoing organ transplantation or HSCT, few studies are available regarding CMV infection in patients with liver failure ( Cho et al., 2019 ). A retrospective study conducted in China analyzed the risk factors for both CMV and Epstein-Barr virus infection and their influence on the liver function of patients with ACLF-based hepatitis B virus, indicating that 5% (5/98) of the patients presented with CMV DNA ( Hu et al., 2018 ). However, the study was conducted on a small scale, and the influence of prognosis on CMV infection was not confirmed.…”

Section: Introductionmentioning

confidence: 99%

Latent Cytomegalovirus Reactivation in Patients With Liver Failure: A 10-Year Retrospective Case-Control Study, 2011-2020

Yang

Zhou

Xiao-mi

et al. 2021

Front. Cell. Infect. Microbiol.

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BackgroundThe aim of this study was to explore potential risk factors for cytomegalovirus (CMV) reactivation and their impact on liver failure patient outcomes.MethodsA 10-year retrospective case–control study was conducted in adult participants, who were diagnosed with liver failure and had undergone CMV DNA tests. CMV reactivation cases were matched with controls at a 2:1 ratio based on age, sex, and year of admission. Univariate and multivariate analyses were used to explore risk factors for CMV reactivation.ResultsBetween January 2011 and April 2020, 198 adult patients with liver failure and available CMV DNA test results were enrolled into the study. Among them, 33 patients had detectable CMV DNA in their plasma (16.7%). Clinical manifestations and liver function were comparable between the CMV reactivation and non-reactivation groups. However, CMV reactivation may triple mortality in patients with liver failure. We found that nearly 50% of patients in the CMV-positive group received glucocorticoids, compared to 13.6% in the CMV-negative group (P=0.000). The median total glucocorticoid dose included 836.5 mg of methylprednisolone (IQR 308.7-1259.0 mg) in the CMV-positive group, which was significantly higher than that in the CMV-negative group. A multivariate analysis revealed that glucocorticoid use significantly increased the risk of CMV reactivation (adjusted OR, 4.84; 95% CI, 1.61–14.49; P=0.005). Patients with CMV reactivation tended to be associated with higher white cell counts (adjusted OR, 1.21; 95% CI, 1.08–1.36; P=0.002).ConclusionsHigh intravenous glucocorticoid doses may be the most important risk factor for CMV reactivation in liver failure.

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Human cytomegalovirus and Epstein-Barr virus infections, risk factors, and their influence on the liver function of patients with acute-on-chronic liver failure

Cited by 21 publications

References 27 publications

Hepatitis Aguda Grave por Coinfeccion por Virus Epstein-barr y Citomegalovirus- reporte de caso y revisión de la literatura

Hepatitis Aguda Grave por Coinfeccion por Virus Epstein-barr y Citomegalovirus- reporte de caso y revisión de la literatura

Epstein-Barr virus infection is associated with a higher Child-Pugh score and may predict poor prognoses for patients with liver cirrhosis

Latent Cytomegalovirus Reactivation in Patients With Liver Failure: A 10-Year Retrospective Case-Control Study, 2011-2020

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