Human Colostrum for Prophylaxis Against Sticky Eyes and Conjunctivitis in the Newborn

Singh, Meharban; Sugathan, P; Ra, Bhujwala

doi:10.1093/tropej/28.1.35

Cited by 13 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It slows catabolism, and it is the only growth factor that can stimulate muscle growth and repair by itself. Two conditions that can be directly healed by the use of breast milk are sore nipples and conjunctivitis . In some regions of the world, human milk has been used topically as a treatment for conjunctivitis, and a study by Ramsey et al assessed the antimicrobial capacity of human milk against Chlamydia trachomatis , a common agent of ophthalmia neonatorum.…”

mentioning

confidence: 99%

Comparison of the Effect of Human Milk and Topical Hydrocortisone 1% on Diaper Dermatitis

Amiri‐Farahani

M.Sc.

Yousefi

2013

Pediatric Dermatology

View full text Add to dashboard Cite

Diaper dermatitis is one of the most common skin problems in infants and children, affecting between 7% and 35% of infants. This randomized clinical trial compared the efficacy of hydrocortisone 1% ointment with that of human breast milk in treating acute diaper dermatitis in infants ages 0 to 24 months. Infants with diaper rash were treated with either hydrocortisone 1% ointment (n = 70) or human breast milk (n = 71) for 7 days. Improvement in the rash from baseline was seen in both treatment groups on days 3 and 7; there was no significant difference in total rash scores on days 3 and 7. Treatment with human breast milk was as effective as hydrocortisone 1% ointment alone. Human breast milk is an effective and safe treatment for diaper dermatitis in infants.

show abstract

mentioning

confidence: 99%

Comparison of the Effect of Human Milk and Topical Hydrocortisone 1% on Diaper Dermatitis

Amiri‐Farahani

M.Sc.

Yousefi

2013

Pediatric Dermatology

View full text Add to dashboard Cite

show abstract

“…Raw breast milk also contains a range of commensal bacteria, and if milk was not prepared in such a way that these were killed, it is possible that the milk microbiome could contribute to its anti-infection properties. One study found that colostrum could help alleviate infant conjunctivitis because the commensal bacteria in the milk outcompeted the pathogenic bacteria when applied to the eye (91).…”

Section: Results and Discussion Network Analysis Of Remedies For Skinmentioning

confidence: 99%

Data Mining a Medieval Medical Text Reveals Patterns in Ingredient Choice That Reflect Biological Activity against Infectious Agents

Connelly¹,

Genio

Harrison

2020

mBio

View full text Add to dashboard Cite

The pharmacopeia used by physicians and laypeople in medieval Europe has largely been dismissed as placebo or superstition. While we now recognize that some of the materia medica used by medieval physicians could have had useful biological properties, research in this area is limited by the labor-intensive process of searching and interpreting historical medical texts. Here, we demonstrate the potential power of turning medieval medical texts into contextualized electronic databases amenable to exploration by the use of an algorithm. We used established methodologies from network science to reveal patterns in ingredient selection and usage in a key text, the 15th-century Lylye of Medicynes, focusing on remedies to treat symptoms of microbial infection. In providing a worked example of data-driven textual analysis, we demonstrate the potential of this approach to encourage interdisciplinary collaboration and to shine a new light on the ethnopharmacology of historical medical texts. IMPORTANCE We used established methodologies from network science to identify patterns in medicinal ingredient combinations in a key medieval text, the 15thcentury Lylye of Medicynes, focusing on recipes for topical treatments for symptoms of microbial infection. We conducted experiments screening the antimicrobial activity of selected ingredients. These experiments revealed interesting examples of ingredients that potentiated or interfered with each other's activity and that would be useful bases for future, more detailed experiments. Our results highlight (i) the potential to use methodologies from network science to analyze medieval data sets and detect patterns of ingredient combination, (ii) the potential of interdisciplinary collaboration to reveal different aspects of the ethnopharmacology of historical medical texts, and (iii) the potential development of novel therapeutics inspired by premodern remedies in a time of increased need for new antibiotics.

show abstract

“…In addition, because the most common class of infection in the first month of life is primarily caused by STD pathogens present in the birth canal (126), the same mucosal antibodies could be used in a predelivery cervicovaginal lavage or applied to newborns' eyes for studies in the prevention of ophthalmia neonatorum. Indeed, in some cultures the mother's colostrum, a fluid rich in SIgA, is applied to the newborns' eyes (127).…”

Section: Potential Preventive Uses For Topically Delivered Mabsmentioning

confidence: 99%

Using Monoclonal Antibodies to Prevent Mucosal Transmission of Epidemic Infectious Diseases

Zeitlin

Cone

Whaley

1999

Emerg. Infect. Dis.

View full text Add to dashboard Cite

Passive immunization with antibodies has been shown to prevent a wide variety of diseases. Recent advances in monoclonal antibody technology are enabling the development of new methods for passive immunization of mucosal surfaces. Human monoclonal antibodies, produced rapidly, inexpensively, and in large quantities, may help prevent respiratory, diarrheal, and sexually transmitted diseases on a public health scale.

show abstract

Human Colostrum for Prophylaxis Against Sticky Eyes and Conjunctivitis in the Newborn

Cited by 13 publications

References 0 publications

Comparison of the Effect of Human Milk and Topical Hydrocortisone 1% on Diaper Dermatitis

Comparison of the Effect of Human Milk and Topical Hydrocortisone 1% on Diaper Dermatitis

Data Mining a Medieval Medical Text Reveals Patterns in Ingredient Choice That Reflect Biological Activity against Infectious Agents

Using Monoclonal Antibodies to Prevent Mucosal Transmission of Epidemic Infectious Diseases

Contact Info

Product

Resources

About