Human colon cancer produces a factor which induces the proliferation of venous endothelial cells

Iwasaki, Katsurou; Yamamoto, Masayuki; Minami, Shigeki; Komuta, Ko; Yamaguchi, Junzo; Furui, Junichiro; Kanematsu, Takashi

doi:10.3892/or.8.5.1057

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…bFGF, when upregulated, contributes in maintaining high levels of VEGF, and therefore it could be involved in resistance to anti-VEGF therapy. Initial evidence about the role of bFGF as prognostic factor in CRC was produced by Iwasaki and colleagues who analyzing resected tissue specimens from a small number of CRC patients, individuated a correlation between bFGF and tumor stage [ 133 ]. Another study, on 52 CRC patients, investigated the potential prognostic role of VEGF, bFGF and NO levels obtaining a significant increases only in VEGF and NO: the determination of serum levels of these factors was proposed to predict the progression of malignancy [ 134 ].…”

Section: Angiogenesis-related Prognostic Biomarkers In Crcmentioning

confidence: 99%

“Vessels in the Storm”: Searching for Prognostic and Predictive Angiogenic Factors in Colorectal Cancer

Angelucci

Monache

Cortellini

et al. 2018

IJMS

View full text Add to dashboard Cite

High expectations are placed upon anti-angiogenic compounds for metastatic colorectal cancer (mCRC), the first malignancy for which such type of treatment has been approved. Indeed, clinical trials have confirmed that targeting the formation of new vessels can improve in many cases clinical outcomes of mCRC patients. However, current anti-angiogenic drugs are far from obtaining the desirable or expected curative results. Many are the factors probably involved in such disappointing results, but particular attention is currently focused on the validation of biomarkers able to improve the direction of treatment protocols. Because clinical studies have clearly demonstrated that serum or tissue concentration of some angiogenic factors is associated with the evolution of the disease of mCRC patients, they are currently explored as potential biomarkers of prognosis and of tumor response to therapy. However, the complex biology underlying CRC -induced angiogenesis is a hurdle in finding rapid solutions. The aim of this review was to explore molecular mechanisms that determine the formation of tumor-associated vessels during CRC progression, and to discuss the potential role of angiogenic factors as diagnostic, prognostic and predictive biomarkers in CRC.

show abstract

Section: Angiogenesis-related Prognostic Biomarkers In Crcmentioning

confidence: 99%