Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production

Maggi, Laura; Montaini, Gianni; Mazzoni, Alessio; Rossettini, Beatrice; Capone, Manuela; Rossi, Maria Caterina; Santarlasci, Veronica; Liotta, Francesco; Riggio, Oliviero; Gallo, Oreste; Palma, Raffaele De; Maggi, Enrico; Cosmi, Lorenzo; Romagnani, Sergio; Annunziato, Francesco

doi:10.1016/j.jaci.2016.06.032

Cited by 81 publications

(85 citation statements)

References 34 publications

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“…ILCs have been shown to regulate B cell responses in mice [102, 103] and humans [104, 105] (Fig. 1).…”

Section: Interaction With Other Cell Typesmentioning

confidence: 99%

“…Noteworthy, several phenotypic differences between mice and humans were described, with murine ILCs expressing APRIL and DLL1, but lacking BAFF and CD40L expression [105]. Moreover, TLR-induced CD40L expression has been recently demonstrated in circulating human ILC2, resulting in these cells gaining the potential to promote IgE production by B cells [104]. …”

Section: Interaction With Other Cell Typesmentioning

confidence: 99%

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The roles for innate lymphoid cells in the human immune system

et al. 2018

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From constituting a novel and obscure cell population, innate lymphoid cells (ILCs) are now accepted as a self-evident part of the immune system, contributing with unique and complementary functions to immunity by production of effector cytokines and interaction with other cell types. In this review, we discuss the redundant and complementary roles of the highly plastic human ILCs and their interaction with other immune cells with the ultimate aim of placing ILCs in a wider context within the human immune system.

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“…ILCs have been shown to regulate B cell responses in mice [102, 103] and humans [104, 105] (Fig. 1).…”

Section: Interaction With Other Cell Typesmentioning

confidence: 99%

Section: Interaction With Other Cell Typesmentioning

confidence: 99%

The roles for innate lymphoid cells in the human immune system

et al. 2018

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“…97 These data suggest ILC2 may influence the B cell and/or IgE compartments in allergic disease. 98 ILC2 also coordinate with cells of the innate immune system. Specifically, basophil derived IL-4 is required for ILC2 responses in a mouse model of atopic dermatitis.…”

Section: Ilc2 Mechanisms Of Pathogenesis In Allergic Diseasementioning

confidence: 99%

Innate lymphoid cells and allergic disease

Stier

Peebles

2017

Annals of Allergy, Asthma & Immunology

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“…A recent study provides evidence that ILC2s can contribute to the production of IgE by B cells . That study showed that upon stimulation with IL‐25 or IL‐33, human peripheral ILC2s can enhance IgE production from autologous B cells through expression of CD154 and IL‐4 production in vitro . The functional significance of ILC2s for IgE production by B cells in allergic and asthmatic patients is unknown.…”

Section: Role Of Ilc2s In Disease Pathogenesismentioning

confidence: 99%

Type two innate lymphoid cells: the Janus cells in health and disease

Maazi

Akbari

2017

Immunological Reviews

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Summary Innate lymphoid cells are functionally diverse subsets of immune cells including the conventional natural killer cells, lymphoid tissue inducers, type 1, 2 and 3 with significant roles in immunity and pathogenesis of inflammatory diseases. Type 2 innate lymphoid cells (ILC2s) resemble type 2 helper (Th2) cells in cytokine production and contribute to anti-helminth immunity, maintaining mucosal tissue integrity and adipose tissue browning. ILC2s play important roles in the pathogenesis of allergic diseases and asthma. Studying the pathways of activation and regulation of ILC2s are currently a priority for giving a better understanding of pathogenesis of diseases with immunological roots. Recently, our laboratory and others have shown several pathways of regulation of ILC2s by costimulatory molecules such as ICOS, regulatory T cells and by compounds such as nicotine. In this review, we summarize the current understanding of the mechanisms of activation and regulation of ILC2s and the role of these cells in health and disease.

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Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production

Abstract: This study provides the first evidence that human ILC2s can express CD154 and stimulate the production of IgE by B lymphocytes through IL-25/IL-33 stimulation or TLR triggering.

Cited by 81 publications

References 34 publications

The roles for innate lymphoid cells in the human immune system

The roles for innate lymphoid cells in the human immune system

Innate lymphoid cells and allergic disease

Type two innate lymphoid cells: the Janus cells in health and disease

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