1981
DOI: 10.1073/pnas.78.12.7754
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Human chorionic gonadotropin radioantibodies in the radioimmunodetection of cancer and for disclosure of occult metastases.

Abstract: Radioimmunodetection (RaID) of tumors containing human chorionic gonadotropin (hCG; choriogonadotropin) was evaluated in 25 patients by injecting "3'I-labeled goat antibody IgG against hCG and performing total-body photoscans with a y scintillation camera 24 and 48 hr later. All 10 testicular cancer patients with proven tumor sites had positive RaID results, whereas three cases without known tumor were negative. Four patients with hydatidiform mole and one with degenerative products of conception showed positi… Show more

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Cited by 50 publications
(13 citation statements)
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“…Preliminary data (not shown) on the uptake of tritiated thymidine or tritiated leucine by JAR cells exposed to carboxypeptidase G2 are in general accordance with these results but remain to be evaluated fully. The incorporation of both thymidine and leucine can theoretically be distorted by folate depletion (Taheri et al, 1981;Grzelakowska-Sztabert, 1983) and are therefore unsatisfactory direct measures of cell viability in this model.…”
Section: Discussionmentioning
confidence: 99%
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“…Preliminary data (not shown) on the uptake of tritiated thymidine or tritiated leucine by JAR cells exposed to carboxypeptidase G2 are in general accordance with these results but remain to be evaluated fully. The incorporation of both thymidine and leucine can theoretically be distorted by folate depletion (Taheri et al, 1981;Grzelakowska-Sztabert, 1983) and are therefore unsatisfactory direct measures of cell viability in this model.…”
Section: Discussionmentioning
confidence: 99%
“…Carboxypeptidase G2 (Sherwood et al, 1985) (Searle et al, 1981) and radioimmunolocalisation studies in patients (Goldenberg et al, 1981;Begent et al, 1985) have already indicated that there is some selective retention of these antibodies in the locality of hCG-producing tumours. Autoradiography with iodine (125I)-labelled antibodies suggests the major proportion remains extracellular in the xenograft model (Sharma, 1983).…”
mentioning
confidence: 99%
“…However, only within the past 5 yr has this method, called radioimmunodetection (2), been found to be effective for imaging cancer by external scintigraphy (3)(4)(5)(6)(7). Although radioimmunodetection was relatively slow in development, there were several advances that enabled its clinical application.…”
mentioning
confidence: 99%
“…The sensitivity of this test exceeds that of any present imaging method so that patients with drug resistant choriocarcinoma are seen with rising serum HCG values but no clear indication of the site of active tumour. Antibody imaging, in which tumours are imaged by external scintigraphy after intravenous injection of radiolabelled antibody directed against HCG provides a way of locating these tumours and demonstrating HCG production at the site concerned. Earlier studies of antibody imaging have shown that large deposits of choriocarcinoma can be located and that the sensitivity was sometimes sufficient to make the investigation useful in clinical decision making (Begent et al, 1980;Goldenberg et al, 1980Goldenberg et al, , 1981.…”
mentioning
confidence: 99%