Human chorionic gonadotropin measurements in parathyroid carcinoma

Rubin, Mishaela R.; Bilezikian, John P.; Birken, Steven; Silverberg, Shonni J.

doi:10.1530/eje-08-0169

Cited by 53 publications

(25 citation statements)

References 25 publications

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“…In contrast to that, three cases which fall in category of markedly high HCG, there was incredibly raised excretion of total HCG 1542 fmol/mg Cr and its malignant isoform 1.5 fmol/mg Cr in urine. The findings of our present study was similar to the results of Rubin et al (Rubin et al, 2008). The augment in urinary HCG showed a signal of more aggressive stage of parathyroid carcinoma.…”

Section: Discussionsupporting

confidence: 93%

Significance of HCG to Distinguish Parathyroid Carcinoma from Benign Disease and in Adding Prognostic Information: A Hospital Based Study from Nepal

Gupta

Mittal²,

Sathian³

2013

Asian Pacific Journal of Cancer Prevention

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Objective: To differentiate between benign and malignant hyperparathyroidism on the basis of excretion of HCG and its malignant isoforms in urine. Materials and Methods: This hospital based study was carried out using data retrieved from the register maintained in Manipal Teaching Hospital from 1 st January, 2008 and 31 st August, 2012. The variables collected were urinary HCG and HCG malignant isoform, calcium and parathyroid hormone. Preceding the study, approval was obtained from the institutional research ethical committee. Analysis was by descriptive statistics and testing of hypothesis. A p-value of <0.05 (two-tailed) was used to establish statistical significance. Results: Out of the 20 cases, 10 were primary hyperparathyroidism and the remainder were parathyroid carcinomas. The urinary HCG 6.1±0.6 fmol/mgCr was with in normal range in benign hyperthyroidism but was markedly elevated in three cases of malignant hyperparathyroidism (maximum value of excretion in urine for HCG was 2323 fmol/mgCr). The excretion of malignant isoform of HCG in urine was 0 in benign hyperparathyroidsm and in four cases of malignant hyperparathyroidism which fell into the category of persistantly low HCG. The maximum excretion of the malignant isoform of HCG in urine was 1.8, in the category of very high HCG. Calcium and parathyroid hormone were mildly raised in benign parathyroidism, while parathyroid hormone was markedly elevated in cases of malignant hyperparathyroidism falling into the category of very high HCG. Conclusions: The excretion of urinary HCG in urine has the ability to distinguish between parathyroid adenomas and carcinomas and thus has potential to become a marker of disease progression in malignant parathyroid disease.

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Section: Discussionsupporting

confidence: 93%

Significance of HCG to Distinguish Parathyroid Carcinoma from Benign Disease and in Adding Prognostic Information: A Hospital Based Study from Nepal

Gupta

Mittal²,

Sathian³

2013

Asian Pacific Journal of Cancer Prevention

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“…Abnormally elevated serum and urinary levels of hCG and its malignant hyperglycosylated isoform have been described in patients with parathyroid cancer, but not in those with benign parathyroid tumors. [94][95][96] These assays might be useful in very selected cases for the diagnosis and monitoring of selected patients. Moreover, elevations of hCG might be predictive of complications such as hip fracture and death.…”

Section: Clinical Aspects Of Primary Hyperparathyroidismmentioning

confidence: 99%

“…Moreover, elevations of hCG might be predictive of complications such as hip fracture and death. 95 Rarely, parathyroid carcinomas are non-functional [3][4][5]46 and at clinical evaluation can be misdiagnosed as thyroid or thymic carcinoma because of locally advanced disease (palpable neck mass, dysphagia, hoarseness due to laryngeal nerve palsy). Immunohistochemical staining for PTH, thyroglobulin, thyroid transcription factor 1, and calcitonin may help ascertain the correct diagnosis.…”

Section: Clinical Aspects Of Primary Hyperparathyroidismmentioning

confidence: 99%

Parathyroid Carcinoma

Cetani

Marcocci

2015

The Parathyroids

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“…of human chorionic gonadotropin have been documented in many patients with PC but not with benign HPT [21,22].…”

Section: Laboratory Testingmentioning

confidence: 99%

Parathyroid Cancer and the CDC73 Tumor Suppressor Gene

Simonds¹

2014

Int. J. Endo. Oncol.

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Parathyroid carcinoma (PC) is a rare endocrine neoplasm, usually causing severe primary hyperparathyroidism, that frequently causes death from unmanageable hypercalcemia. PC is frequently associated with somatic inactivating mutations of the CDC73 gene (previously called HRPT2), a gene discovered in association with the familial hyperparathyroidism-jaw tumor syndrome. DNA analysis for CDC73 mutation should be performed on all patients with seemingly sporadic PC since some 25% will carry a germline mutation. It is often difficult to make a firm diagnosis of PC by histopathology alone. That diagnosis often depends on the presence of local tissue invasion or distant metastases. If PC is suspected, en bloc resection at initial surgery is recommended. Medical therapy with cinacalcet, bisphosphonates or denosumab may temporarily ameliorate the hypercalcemia of inoperable PC.

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Human chorionic gonadotropin measurements in parathyroid carcinoma

Cited by 53 publications

References 25 publications

Significance of HCG to Distinguish Parathyroid Carcinoma from Benign Disease and in Adding Prognostic Information: A Hospital Based Study from Nepal

Significance of HCG to Distinguish Parathyroid Carcinoma from Benign Disease and in Adding Prognostic Information: A Hospital Based Study from Nepal

Parathyroid Carcinoma

Parathyroid Cancer and the CDC73 Tumor Suppressor Gene

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