Human chorionic gonadotropin as a predictor of outcome in assisted reproductive technology pregnancies

Homan, Gillian; Brown, Susan; Moran, John L.; Homan, Sean; Kerin, John F.

doi:10.1016/s0015-0282(99)00512-9

Cited by 66 publications

(47 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is well documented in the literature that levels of β-hCG in early pregnancy are highly predictive for pregnancy outcome after fresh ET, however prognostic values and β-hCG thresholds are not consistent [1,[4][5][6][7][8][9][10][11]. The most important factor for inconsistent results is different timing of the β-hCG sampling.…”

Section: Discussionmentioning

confidence: 99%

“…There is no data specifically considering differences in β-hCG levels after FET compared to fresh ET. Only a few published studies included analysis of β-hCG levels after FET with very limited data on this topic [1,6,10]. These studies have shown no differences in β-hCG levels after fresh ET and FET.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have investigated the value of β-hCG in the prediction of viable pregnancy after MAR and found correlation between β-hCG levels and pregnancy outcome [1,[4][5][6][7][8][9][10][11]. The threshold levels of β-hCG with best prediction as well as the reliability of prediction, however, vary between studies.…”

Section: Introductionmentioning

confidence: 99%

“…However, only a few published studies included the analysis of β-hCG levels after FET and they present with inconclusive results [1,6,10]. Furthermore, there is no data specifically considering differences in β-hCG levels after transfer of vitrified-warmed embryos at blastocyst stage compared to fresh blastocyst transfer.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Human chorionic gonadotropin levels are equally predictive for pregnancy outcome after fresh and vitrified-warmed blastocyst transfer

Reljič

Knez

Vlaisavljević

2013

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The aim of the present study was to evaluate if the live birth predictive values of β-hCG levels differ in fresh and vitrified-warmed blastocyst transfer cycles. Methods In the retrospectively designed study, 775 cycles with positive β-hCG values 13 days after fresh blastocyst transfer (fresh ET; n =568) or vitrified-warmed blastocyst transfer (FET; n =207) were selected for analysis. Average β-hCG levels stratified according to pregnancy outcome (biochemical pregnancy, spontaneous abortion, ectopic pregnancy, and singleton or twin birth) were compared between fresh ET and FET cycles. To determine the optimal sensitivity and specificity of β-hCG levels for live birth prediction, a ROC curve was constructed. Fisher's exact test was used to compare the positive predictive values (PPV). Results Average β-hCG levels stratified according to pregnancy outcome were not statistically different between fresh ET and FET cycles. In fresh ET and in FET group, the β-hCG levels were significantly higher in pregnancies resulting in live birth compared to non-viable pregnancies (1,035 vs. 462 IU/L, p < 0.001 and 968 vs. 411 IU/L, p <0.001). Optimal cut-off level for live birth prediction was 495 IU/L (sensitivity 83.0 %, specificity 71.8 %) after ET and 527 IU/L (sensitivity 80.0 % and specificity 76.6 %) after FET. The PPV for live birth rate in the groups after ET and FET were 90.6 % and 84.9 % respectively, without statistically significant difference (p >0.05). Conclusion Beta-hCG levels after fresh and vitrified-warmed blastocyst transfer are equally predictive for pregnancy outcome. Clinicians can be encouraged to interpret β-hCG results in the same manner.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Human chorionic gonadotropin levels are equally predictive for pregnancy outcome after fresh and vitrified-warmed blastocyst transfer

Reljič

Knez

Vlaisavljević

2013

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Few studies have attempted to use serum progesterone assay to predict the outcome of pregnancy in IVF/ICSI or in natural pregnancies and none has produced convincing conclusions (Homan et al 2000). It is essential to study women after natural conceptions without exogenous progesterone support, when the relation between serum progesterone and viability of the first trimester pregnancy was evaluated (Vicdan & Zeki Isik 2001;Zainab Ali Abdulla Al 2000).…”

Section: Introductionmentioning

confidence: 99%

Relation between single serum progesterone assay and viability of the first trimester pregnancy

Abdelazim¹,

Belal²,

Makhlouf³

2013

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

This study was designed to detect the relation between serum progesterone and viability of pregnancy during the first trimester. Prospective study carried out in Al-Rashid Maternity and Ahmadi Kuwait oil company hospitals, over three years from February 2009 to February 2012. Two hundred and Sixty (260) pregnant women were hospitalized due to vaginal bleeding and/or abdominal pain during the first trimester of their pregnancies and were included in this study. Women included in this study were; sure of dates, conceived spontaneously with no history of infertility and had a positive serum pregnancy test. 2 ml blood samples were taken for women included in this study for serum progesterone assay. Women included in this study were followed by ultrasound for the viability of the pregnancy till the end of first trimester and the outcome of their pregnancy were recorded, while women with exogenous progesterone support or multiple pregnancies or suspected ectopic pregnancy or Hydatiform mole were excluded from this study. Data were collected and statistically analyzed to detect the relationship between serum progesterone level and viability of pregnancy during the first trimester. The mean age of the studied population was 32.7 ± 5.1 years, the mean gestational age at progesterone assay was 9.7 ± 0.5 week and by the end of the first trimester, women included in this study were classified according to the viability of their pregnancies into; viable pregnancy group 178 (68.5%) cases and non-viable pregnancy group (ended by miscarriage) 82 (31.5%) cases. The mean serum progesterone of the studied population was significantly high in viable pregnancy group (46.5 ± 7.4 ng/ml) compared to non-viable pregnancy group (9.9 ± 4.8 ng/ml), (p <0.05). In this study; 6.7% of viable pregnancies had serum progesterone level <10 ng/ ml, while 20.7% of non-viable pregnancies had serum progesterone level >10 ng/ml, the serum progesterone at cut off level 10 ng/ml was 79.3% sensitive to diagnose non-viable pregnancy and was 93.3% specific to diagnose viable pregnancy. Also, in this study; 1.1% of viable pregnancies had serum progesterone level <20 ng/ ml, while 4.8% of non-viable pregnancies had serum progesterone level >20 ng/ml, the serum progesterone at cut off level 20 ng/ml was 95.1% sensitive to diagnose non-viable pregnancy and was 98.9% specific to diagnose viable pregnancy. Serum progesterone is a reliable marker for early pregnancy failure and single assay of its serum level can differentiate between viable and non-viable pregnancies.

show abstract

Levels of serum β‐human chorionic gonadotropin after embryo transfer and subsequent miscarriage, pre‐eclampsia, and intrauterine growth restriction

Kabodmehri,

Ghanami Gashti,

Zahiri Sorouri

et al. 2024

Health Science Reports

View full text Add to dashboard Cite

BackgroundThis study aimed to examine maternal serum concentration of β‐human chorionic gonadotropin (β‐hCG) on Day 16 after embryo transfer and risk of miscarriage, pre‐eclampsia, and intrauterine growth restriction (IUGR).MethodsIn this study, we evaluated 125 pregnancies following in vitro fertilization (IVF). β‐hCG concentrations were measured on the morning of Day 16 after embryo transfer. Baseline characteristics of the study participants were also recorded.ResultsConcentrations of β‐hCG on Day 16 after embryo transfer were inversely associated with the higher risk of miscarriage (p < 0.001), but did not with pre‐eclampsia and IUGR (p > 0.05). Spearman's correlation coefficient showed a reverse and significant association between β‐hCG and higher risk of miscarriage (σ = 0.531 and p < 0.001). There was a significant association between frozen embryo transfer and the risk of IUGR and pre‐eclampsia (p = 0.005 and p = 0.023, respectively).ConclusionsMaternal serum concentrations of β‐hCG on Day 16 after IVF/embryo transfer were associated with the higher risk of miscarriage, but not pre‐eclampsia and IUGR.

show abstract

Human chorionic gonadotropin as a predictor of outcome in assisted reproductive technology pregnancies

Cited by 66 publications

References 7 publications

Human chorionic gonadotropin levels are equally predictive for pregnancy outcome after fresh and vitrified-warmed blastocyst transfer

Human chorionic gonadotropin levels are equally predictive for pregnancy outcome after fresh and vitrified-warmed blastocyst transfer

Relation between single serum progesterone assay and viability of the first trimester pregnancy

Levels of serum β‐human chorionic gonadotropin after embryo transfer and subsequent miscarriage, pre‐eclampsia, and intrauterine growth restriction

Contact Info

Product

Resources

About