Human chorionic gonadotrophin indirectly activates peripheral γδT cells to produce interleukin‐10 during early pregnancy
Liman Li,
Yuan Liu,
Wenjie Zhou
et al.
Abstract:BackgroundsThe immunomodulatory properties of human chorionic gonadotrophin (hCG) have been identified to be critical for successful pregnancy. However, the effects of hCG on peripheral γδT cells during early pregnancy have not been reported previously.MethodsWe cocultured the purified γδT cells and peripheral blood mononuclear cells (PBMCs) with early pregnancy‐relevant hCG concentrations and investigated the changes in the immune functional characteristics of γδT cells via flow cytometry assays.ResultsThe ra… Show more
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