Human Chagas Disease and Migration in the Context of Globalization: Some Particular Aspects

Dias, João Carlos Pinto

doi:10.1155/2013/789758

Cited by 61 publications

(64 citation statements)

References 26 publications

(105 reference statements)

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“…That is, human movement along the transportation infrastructure of the connected urban centers could facilitate the migration of T. infestans and reservoir species of T. cruzi among districts [34]. One potential hypothesis is human-mediated transport of guinea pigs, which are regularly brought to the study area from farms or purchased at a market (~8% of all individual guinea pigs).…”

Section: Discussionmentioning

confidence: 99%

Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru

Berry

Salazar-Sánchez²,

Castillo-Neyra

et al. 2019

Preprint

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Anthropogenic environmental alterations such as urbanization can threaten native populations as well as create novel environments that allow human pests and pathogens to thrive. As the number and size of urban environments increase globally, it is more important than ever to understand the dispersal dynamics of hosts, vectors and pathogens of zoonotic disease systems.For example, a protozoan parasite and the causative agent of Chagas disease in humans, Trypanosoma cruzi, recently colonized and spread through the city of Arequipa, Peru. We used population genomic and phylogenomic tools to analyze whole genomes of 123 T. cruzi isolates collected throughout Arequipa to determine patterns of T. cruzi dispersal. The data show significant population genetic structure within city blocks -parasites in the same block tend to be very closely related -but no population structure among blocks within districts -parasites in neighboring blocks are no more closely related to one another than to parasites in distant districts. These data suggest that T. cruzi dispersal within a block occurs regularly and that occasional long-range dispersal events allow the establishment of new T. cruzi populations in distant blocks. Movement of domestic animals may be the primary mechanism of inter-block and inter-district T. cruzi dispersal. Author SummaryUrbanization creates environments that are ideal for some human pests and pathogens. As the number and size of urban environments increases globally, it is becoming vital to understand how human disease-causing pathogens, their vectors, and their non-human hosts disperse through urban landscapes. Here we study a population of Trypanosoma cruzi -the protozoan parasite and causative agent of Chagas disease in humans -that recently colonized the city of Arequipa, Peru. We use population genomic and phylogenomic tools to understand how this parasite population dispersed through the city to achieve its current distribution and abundance.We show that T. cruzi collected from the same city block tend to be very closely related, while those from neighboring blocks are often as distantly related as those from blocks in distant districts. The data suggest that vectors facilitate frequent within-block dispersal of the parasite, while domestic animal movement may facilitate the relatively infrequent inter-block and interdistrict dispersal.

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Section: Discussionmentioning

confidence: 99%

Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru

Berry

Salazar-Sánchez²,

Castillo-Neyra

et al. 2019

Preprint

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“…11,16,26,35 This is often seen as a result of an abrupt decentralisation of health services, transferring disease control and surveillance functions to peripheral governmental levels, without proper preparation for these governments to take over the surveillance responsibilities. 4,34 Although ChD produces important social losses related to mortality, incapacity to work and medical costs, due to severe cardiac and digestive impairments that may be caused by the disease's chronic form, these costs are frequently neglected by governments.…”

Section: Discussionmentioning

confidence: 99%

“…35 This is at the expense of the ChD control program, especially where the disease has already been considered as under control and, as a consequence, losing visibility. 4,11,16 Furthermore, it has been argued that the 2006 PAHO certification may have led to a misbelief that the disease was eradicated. 36 (ii) The residual foci of T. infestans, which can proliferate in the absence of control and epidemiological surveillance, especially in pockets of poverty.…”

Section: Discussionmentioning

confidence: 99%

“…In Latin America, the disease was initially limited to rural areas, marked by poverty, migrations and poor working conditions and employment practices. 16 In Brazil, regions traditionally considered as endemic for vector transmission include areas from the South, Southeast, Northeast and Midwest regions. 13 However, in Brazilian history, the modernisation of agricultural production to meet the market needs of a globalised world and the inequalities in the old production system, 4 triggered intense rural-urban migrations after the 1950s, leading to displacement of over 40 million people from the fields to urban centres.…”

Section: 13mentioning

confidence: 99%

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Evolution of Chagas’ disease in Brazil. Epidemiological perspective and challenges for the future: a critical review

Corassa

Aceijas

Alves

et al. 2016

Perspect Public Health

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Aims: This paper aimed to provide a critical review of the evolution of Chagas' disease in Brazil, its magnitude, historical development and management, and challenges for the future. Methods: A literature search was performed using PubMed, SciELO and Google Scholar and throughout collected articles' references. Narrative analysis was However, there are still challenges, such as the domiciliation of new vector species, the need for medical care of the infected individuals, the prevention of alternative mechanisms of transmission, the loss of political concern regarding the disease and, the weakening of the control program. Conclusion: Despite the progress towards control, there are still many challenges ahead to maintain and expand such control and minimise the risk of re-emergence.

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“…Chagas disease remains a serious public health problem worldwide, where its economic and social repercussions are of great magnitude [1]. The infection is endemic in South America and emergent in Europe and the United States [2]. This parasitic disease affects 6-7 million people worldwide, causing more than 7,000 deaths each year [3].…”

Section: Introductionmentioning

confidence: 99%

The Cost of Lost Productivity due to Premature Chagas Disease-Related Mortality: Evidence from Colombia (2010-2017)

Olivera¹,

Palencia-Sánchez²,

Riaño-Casallas³

2020

Preprint

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Economic burden due to premature mortality has a negative impact not only in health system even though in the society. The aim of this study was to estimate the potential years of work tenure lost (PYWL) due to Chagas disease in Colombia from 2010-2017. National data on mortality by sex and ages between 15 and 62 dues to Chagas from 2010 to 2017. The PYWL methodology was applied to assess the impact of Chagas disease in workers who suffer from them. In total, 1,261 deaths were analyzed in the study, of which 60% corresponded to males. The loss of labor productivity caused by Chagas disease was estimated at $29 million. Overall, 48,621 PYWL were lost, and there was an average of 21 years for all subjects with Chagas. Throughout the analyzed period, PYWL increased substantially, and it is necessary to continue with early detection programs to avoid premature death in working age population.

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Human Chagas Disease and Migration in the Context of Globalization: Some Particular Aspects

Cited by 61 publications

References 26 publications

Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru

Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru

Evolution of Chagas’ disease in Brazil. Epidemiological perspective and challenges for the future: a critical review

The Cost of Lost Productivity due to Premature Chagas Disease-Related Mortality: Evidence from Colombia (2010-2017)

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